I am brand new here to the forum. I am looking for some guidance on how to come off Sertraline which I have been on for as long as I can remember. 20 years plus. I am on 150 mg a day and I tried to come off them before by reducing to 100 mg but side effects of feeling really low, confused and irritable kicked in. I am considering taking 5-htp as it has some great reviews. Do I have to stop Sertraline before I start 5-htp or can I take both together to being with and then reduce the Sertraline. I really want to come off this. Any help greatly appreciated.