Thyroid UK
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Advice on dosing NDT

Hi all i've been on NDT 3 weeks now 1 grain (levo was 125/150) started off feeling great but over the last week i'm feeling over medicated (jittery, punding heart on running up the stairs, dizzy light headed and headaches - although those could be my ongoing sinus problems?) am i on too much? Should i reduce to 3/4 of a grain? Your wisdom needed.

5 Replies


You were over medicated on 125/150mcg Levothyroxine but I think you are very probably under medicated on 1 grain NDT. 1 grain NDT is roughly equivalent to 65mcg T4.

Jitteriness, palpitations, pounding heart and dizziness can be symptoms of under and over medication.

I would increase dose by half a grain (30-32.5mg) and see whether symptoms improve. I would hold at 1.5 grains for 6-8 weeks and have a thyroid test including FT3 before increasing further.


I am not a medical professional and this information is not intended to be a substitute for medical guidance from your own doctor. Please check with your personal physician before applying any of these suggestions.


Thanks for that it's all a bit new to me and i didn't know what to do for the best up or down. I will take your advice.


This link may be helpful:-


Hi Clutter you were so helpful when i posted before i thought i would ask your advice again.

It's been 3 weeks since i increased by 1/2 a grain and it definately made a difference i felt much better.

However i am now feeling awful again with the headaches/dizziness and totally exhausted.

I've had a blood test today but as you know the results take a while.

I wonder if i still need a little more NDT say 1/4 grain?

I have also had results from genova and my cortisol levels throughout the day are higher than they should be.

I don't know what to do about that as everything i read confuses me as my head swims and i can't concentrate.

Your wise words would be appreciated.




Thyroid results and ranges should be available in a couple of days. Post them in a new question and members will advise whether to increase dose.

I can't advise about cortisol. Write a new post and include the results and ranges and ask for advice.


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