Slightly elevated ALT (liver function) and CRP with Hashimoto's?

Has anyone else had a liver function test (ALT) coming back slightly elevated? CRP is also a bit high, 9.6 (upper limit is 5). GP is not bothered at all (either it's normal for me, or it's because I'm overweight), but online research says it may be due to Hashimoto's?

[misswinky34]

Hi I had raised ALT cells twice with not really any explanation, other than hashimotos.

Went to the doctor over palpitations and rapid heartrate. Symptomatically it sounded like graves but I'm definatly under with Hashi and am on 125 Levo. He did a barrage of blood work on me which flagged up the ALT

Target range was below 50, my result was 68, he suggested I stopped any alcohol for two weeks, the result dropped to about 59 and said stop any alcohol for a month. Then the result was 49 so I was within range. GP wasnt concerned and I was not excessively drinking, only maybe a half bottle of wine over the weekend. I am overweight too, again not excessive but he kind of drew a blank with the ALT result as the rest of my MOT they did on me came back normal. 😊 Xxxx

[Starfish123]

I've had elevated and raised ALT levels. It was due to my gallbladder, do you have any pain under your right shoulder blade, it could just be a general rumble or excruciatingly painful depending on what you have eaten.

[Hidden in reply to Starfish123]

Thank you! Gallbladder is out since 2006 (was pretty bad). Liver function was rather off then indeed, but only slightly elevated now.

[Starfish123 in reply to Hidden]

It's not that then, what about excess sugar, that would cause problems for the liver?

[Rebec in reply to Starfish123]

Why under the shoulder blade when the gallbladder is near the liver? During one of the gallstones "attack", I thought I was having a heart attack so for me the pain was concentrated around my stomach area.

[Starfish123 in reply to Rebec]

For the majority of my pain and many others the main pain is under the right shoulder blade, I even get some now 2 years after my gallbladder has been removed. Yes the really worst pain does mimic a heart attack as its centre of the chest and is awful and can't go on for some time. If I could make it to the shower I found this helped the pain, but I was usually lying on my bed in agony.

[Fruitandnutcase in reply to Starfish123]

I had a neighbour many years ago who had gall bladder problems, she eventually had it removed but she said the pain was simply unbelievable - far worse than anything she had ever felt including giving birth and she had one C section and one 'normal' delivery.

[radd]

Kilbu,

Abnormal liver enzyme levels (ALT) are common in unmanaged hypothyroidism and may progressively increase as thyroid hormone lowers. Also common is high cholesterol, LDL, and triglycerides as thyroid hormone helps the liver break down the cholesterol circulating in your blood and stimulates other enzymes needed to rid your body of triglycerides.

The liver metabolises thyroid hormones converting from T4 - T3 and also produces TBG (Thyroid binding globulin) to bind & transport the hormones around the body but liver dysfunction (and congestion) will impair how thyroid hormones are converted, transported, and excreted from the body and so it becomes a vicious circle.

If the liver is not detoxifying optimally, a build-up of unmetabolized hormones circulating in the blood- stream may cause abnormal hormone responses. Partially metabolised hormones can bind to hormone receptor sites blocking normal hormones from binding.

Getting optimal thyroid hormones to work properly lowered my raised liver enzymes as the better the liver can convert, the more available hormone is produced which in turn increases production of more..

Any antioxidants will help but I found Vitamin C and milk thistle and alpha lipoid acid to be most beneficial.

.

Connection Between Low Thyroid Hormone & Liver Dysfunction.

endocrineweb.com/profession...

[Rapunzel in reply to radd]

Another rockin' post radd . Any clues re elevated CRP ? tysm x

[radd in reply to Rapunzel]

Rapunzal ,

I think elevated CRP is multifactorial but as Hashi often means elevated thyroid antibodies which generates inflammation, it must make sense to reduce these with gluten free diet, healthy life style & optimal nutrients, etc...

As inflammation is the release of chemical messengers in the body that create swelling inside, it can be hugely destructive causing fatigue and puffiness, muscle and joint pain, even brain fog.

My last CRP was elevated and thyroid antibodies stubbornly sit at 300 refusing to reduce but I feel well except for my mouth (thick saliva issues)..

Elevated CRP (together with other inflammatory cytokines) will reduce T3 tissues levels (by decreasing D1 deiodinase activity) and conversion of T4-T3. It can also increase activity of deiodinase D2 and suppress the TSH, meaning serum bloods may show good results (in a doctors eyes) when hypo symptoms are felt .

I have also read of the inflammatory suppression of TSH being used as a reason for reduction in thyroid meds, even when there is clearly not enough being medicated...(ignorant doctors), when optimal thyroid meds would in fact help reduce the inflammation.

Additionally, inflammation will stimulate D3, producing too much reverse T3 and further causing reduced T3 levels.

However, remember CRP is a nonspecific marker to be used with others as there are many reactive proteins, and any raised level results should be looked at within the whole picture.

Bought any more hair dye Rapunzal ? ? ... ;o)) ....

[Rapunzel in reply to radd]

Thanks radd you are a wag !

Only for my head... and that's honey blonde - or blonde honey, as I used to be in pre Hashi times of yore xxx

Nevermind. Still here, innit tho ?

[June25]

Have you been tested for hepatitis C and hepatitis B? GPs often neglect to run these simple tests if you don't appear to have risk factors but they will if you specifically request it. These diseases can be symptomless for a long time, so it is worth getting the tests if only to eliminate them as a possible cause of elevated ALT.

June