Hello again. I now have a private prescription for NDT and it is on order. Currently on 100mg levothyroxin and have posted recent results on here so pretty much all set. I have a thermometer and blood pressure monitor that I have been using to ensure that I know my baseline readings before the switch. My doctor suggested I start at 1/2 grain and I understand that I should increase in 1/4 grain increments every two weeks. Are there any exceptions to this regime bar my reaction to the initial dose? It seems like a huge leap into the unknown. Currently bed-based with CFS/ME and dependent on carers so don't have much wiggle room with my symptoms but starting the experiment with hope.