Thyroid UK
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Thyroid Antibodies Advice

Hi Everybody

I recently had my antibodies tested because they hadn't been tested for years, the results were TPO abs 17 (normal) and Thyroglobulin Antibody 318 (abnormal). My question is if the TPO reading is now normal does this mean my thyroid is no longer under attack? My previous TPO reading was 172 in 2012.

My Dr wasn't too concerned about the TgAbs as he says this just confirms an auto immune thyroid condition.

Thanks for your help.

4 Replies

Runnergirl This is from the Stop the Thyroid Madness website

"The second antibody, TgAb, attacks the key protein in the thyroid gland, the thyroglobulin, which is essential in the production of the T4 and T3 thyroid hormones."

So with positive TG antibodies your thyroid is still under attack.

Your doctor is right, it does confirm an autoimmune thyroid condition, which is Hashimoto's which you already know you have (from a previous post), just a shame he's not concerned because either TPO or TG antibodies attack your thyroid and will eventually destroy it.

Your TPO antibodies will probably continue to fluctuate as it is the nature of the beast.

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Dear SeasideSusie

Thank you so much for replying, my Dr implied the Tg Abs weren't relevant and said they only measure them in thyroid cancers, but what you say makes sense, the gland is still under attack.

Great name by the way!




Yes, it means TPOAb activity that was previously attacking the enzyme Thyroid Peroxidase has reduced but could be reactivated if the trigger was experienced again.

Unfortunately, your doctor is clueless as both sets of antibodies denote an autoimmune condition and elevated TGAb's are still attacking thyroglobulin (protein) causing a gradual destruction of follicles in the thyroid gland.

Members have found eating gluten free has helped reduce thyroid antibodies.


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Dear Radd

Thank you for replying, I think if this may be why I have seen little swellings forming all over my thyroid area over the past few years which I'm guessing are as a result of the TgAbs attacking the thyroid follicles maybe?

Kind regards


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