Thyroid UK
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Beneficial method of dosage

I hope that you will opt for natural thyroid for a variety of reasons. But, no matter what you take please consider this: taking 1/2 of my dosage once in AM once in early PM

separate eating time from dosage time, minimum 1 hour before and 1 hour after

intake of calcium, by supplement and food, if taken too close to dosage, interferes with

utilization of the thyroid

7 Replies

Thanks for your post and these two excerpts also help us to get the best from our thyroid hormone replacements and first is very similar to you advice:

By taking T3 with meals, a patient reduces the amount of T3 that will enter her blood. Some food constituents, such as calcium, bind thyroid hormone in the GI tract. This effectively limits the amount of T3 that absorbs into the blood, the rise of the blood T3 level, and the brief exposure of the heart to higher concentrations of T3. But there is a problem with this approach.

The patient who takes T3 (or T4) with meals won’t have anywhere near an accurate idea of how much T3 enters her blood. Different meals will contain different amounts of T3-binding substances that will reduce the amount of T3 that enters the blood. One meal may contain a small amount of T3-binding substances; another may contain a large amount. As a result, the amount of T3 that enters the blood after meals is likely to vary a lot. Accordingly, the degree to which T3 drives the patient’s metabolism any day is also likely to vary widely.

Taking T3 with meals, then, blurs the relationship a patient and her doctor may look for between her dose of T3 and her metabolic status. The proper solution is simply to reduce the amount of T3 the patient takes on an empty stomach. With this approach, the relationship between a particular dose of T3 and metabolic status will be far clearer.

2. Dr. Lowe: As a rule, our patients take thyroid hormone only once per day. An advantage of this one-per-day schedule is that it’s easier to find a window for good intestinal absorption—when the stomach or small intestine doesn’t contain food.

Most of our patients wait at least one hour after taking thyroid hormone before they eat. Or they wait at least two hours after eating before they take thyroid hormone. The two hour wait is a rough estimate of the time it takes for food to pass through the stomach and small intestine. It’s worth noting, however, that several factors can increase the time a patient should wait before taking thyroid hormone.

One factor is being female.

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Why do you hope that, gbccs? I tried NDT for years and ended up bed-bound, and as fat as a whale! It just didn't suit me, and it doesn't suit a lot of people - especially if they have Hashi's. I'm better on synthetic T3 only.

There is no one 'best' form of thyroid hormone replacement because we're all different, and we all have to find what's best for us.

And, if I were you, I'd leave four hours between thyroid hormone and calcium supps, if you want to absorb any hormone. Or any calcium, come to that. But then, I wouldn't recommend taking calcium supps, anyway. :)

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I tried the am and noon and found it dragged me down. This was advice from two 'integrative' doctors. I don't know if they're all reading the same book, but it did not help me and my T4 went high. I take just the T4 in the am along with some HC and I do feel better. Not great as can be, but def better. The kicker was adding the HC.


Marvalus, I think you've answered on the wrong thread. I Don't know what you're referring to. :(


The OP is talking about taking some in the morning and some in the evening.


Ah, ok, but l didn't, so it was a bit confusing. lol

if you want to make a general comment, type it in the reply box at the bottom of the page. Clicking on the reply button at the end of someone's response means you're making a comment on something they've said. :)


Hydrocortisone. I think it is used by people with severely low adrenal function, but please don't quote me.


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