CONCLUSIONS:
l-thyroxine taken at bedtime by patients with primary hypothyroidism is associated with higher thyroid hormone concentrations and lower TSH concentrations compared to the same l-thyroxine dose taken in the morning. At the same time, the circadian TSH rhythm stays intact. Our findings are best explained by a better gastrointestinal uptake of l-thyroxine during the night.
That is interesting and good for those who dose at night.
Not for me though shaws due to sometimes eating too late, sometimes eating too early and then needing a snack before bed, and sometimes crashing out and going to bed really early.
I always wake early morning and take first thing.
F
How interesting shaws. If they hadn't taken measurements hourly, I'd have wondered if the morning TSH measurement was just depressed by bedtime administration. I wonder by how much the morning measurements of TSH in particular were affected ? Also if measurements at a particular time of day were affected less? Just thinking of timing of blood tests ...
Any thyroid hormone replacement can cause suppressed TSH that includes levo.
Thanks Shaws. Nicely summarised conclusion. When I read the report myself I thought it recommended morning dosage until I ploughed through the gobblegook. When I saw my endocrinology yesterday I tried discussing it but he was insistent that morning dosage was best. Reading your blog made me stick with nighttime dosage which I have followed for six months now (after first starting with morning dosage).
lost in translation...
Morning? or Bedtime?
