I take 5 quarter pills of Cynomel per day. Until last week I had been dividing them into 3 doses. I have now changed to 5 doses - 6am, 9am, 12 o'clock, 3 pm and 6 pm. My thinking behind this is because they only kick in for 2 or 3 hours the effect would be more constant. Of course, it's a little trickier, means setting the iPhone alarm to 3 hourly intervals. Any thoughts anyone? Cheers.