My doctor wants me to add low dose topical progesterone cream to my regime. I began on T3 two months ago - main concern is facial edema and fatigue, hair loss and muscle pain. I am on a relatively high dose of 180 mcg T3 and no changes yet. I am wondering also about treating adrenals but not sure how to go about it. My urine and blood showed high cortisol but saliva showed low in the am and noon (within range) and high afternoon and evening (but within range). So, I am not sure if they are over or underactive.