Have NHS endo appointment. Anyone direct me to info I can print out about T3 for him?

[Anuba]

I would like to print out some info regarding T3 etc for my doc as me just being on T4 is not working for me despite TSH going down I still have low t3 etc....dont seem to be converting? Any links to something I could print out for them would be amazing....thanks all.

[shaws Administrator]

If you email [e-mail] and ask for a copy of the Pulse Online article by Dr Toft and question 6 says that some of us need a low or suppressed T4 or the addition of 10mcg of T3 can be added whilst reducing levothyroxine by 50mcg levothyroxine.

[Anuba in reply to shaws]

Thanks

[Clutter]

This link might help, Anuba eje-online.org/content/161/...

[Anuba in reply to Clutter]

Thanks

[shambles]

And this from this year new study nature.com/nrendo/journal/v...

Paradigm shifts in thyroid hormone replacement therapies for hypothyroidism

Impaired psychological well-being, depression or anxiety are observed in 5–10% of hypothyroid patients receiving levothyroxine, despite normal TSH levels. Such complaints might hypothetically be related to increased free T4 and decreased free T3 serum concentrations, which result in the abnormally low free T4:free T3 ratios observed in 30% of patients on levothyroxine. Evidence is mounting that levothyroxine monotherapy cannot assure a euthyroid state in all tissues simultaneously, and that normal serum TSH levels in patients receiving levothyroxine reflect pituitary euthyroidism alone. Levothyroxine plus liothyronine combination therapy is gaining in popularity; although the evidence suggests it is generally not superior to levothyroxine monotherapy, in some of the 14 published trials this combination was definitely preferred by patients and associated with improved metabolic profiles. Disappointing results with combination therapy could be related to use of inappropriate levothyroxine and liothyronine doses, resulting in abnormal serum free T4:free T3ratios. Alternatively, its potential benefit might be confined to patients with specific genetic polymorphisms in thyroid hormone transporters and deiodinases that affect the intracellular levels of T3 available for binding to T3 receptors. Levothyroxine monotherapy remains the standard treatment for hypothyroidism. However, in selected patients, new guidelines suggest that experimental combination therapy might be considered.

Hope it goes well for you.

[Anuba in reply to shambles]

Thanks