I started on 10 mcg of t3 along with t4 which was increased to 20 when I couldn't stay awake! Dr Skinner increased it gradually up to 60 and said to take it all down at once but as I read more about t3 I decided to do 3/4 doses a day instead. It seemed to make sense that as your body made t3 as and when it was needed to take it gradually throughout the day! I didn't do as well as I thought I would do - when I first started t3 it made so much difference that I thought I would go from strength to strength once I was on enough. When I didn't seem to get as well as I'd hoped just around the time dr Skinner died I re thought what he'd told me and decided to try all down at once! I must say that it has made a big difference for me! I feel so much better that at last I can say I am on the road to recovery after so many years. Thanks dr Skinner! I am so glad I met you!