In the light of Nice's new/revised statin "guidance", the following paper seems to have become of the utmost importance to many here. Especially the undiagnosed.
Posted separately so as to enhance the impact of the story already posted by Marz.
Endocrinol Metab (Seoul). 2013 Dec;28(4):331-4. doi: 10.3803/EnM.2013.28.4.331. Epub 2013 Dec 12.
Rhabdomyolysis and acute kidney injury associated with hypothyroidism and statin therapy.
Ahn P1, Min HJ1, Park SH1, Lee BM1, Choi MJ1, Yoon JW1, Koo JR2.
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
Hypothyroidism, Rhabdomyolysis, Statins
PMID: 24396699 [PubMed]
Full paper here: