Ive been diagnosed Hashimoto's for 3 years and RLS 1 year. We tried natural remedies - no caffeine, alcohol, increase exercise, quinnine etc to no avail so I'm now on Requip too. I take 400mcg tramadol to help with the leg pain daily but recently my RLS progressed to my left arm, making sleeping unbearable. The doctors put me on Requip and I was wondering how long before I will start to notice any difference. I'm on 200mcg levothyroxine.