Hello, I have tried all the usual stuff to help my IBS. At the moment I am following the low FODMOP diet, taking Symprove and giving amitryptiline a go. I struggle to get the dosage right though. Anything below 25mg doesn't seem to do much but 50mg is very sedating and seems to cause bad stomach pain (which wasn't really a problem originally). I'd be interested to know if anyone has found amitryptiline helpful.