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Three clinical trial options after Zytiga fails
With Zytiga losing efficacy, we have choices ahead of us:
Xofigo
, Jevtana, or three different clinical trials. I feel knowledgeable about the risks and benefits of
Xofigo
and Jevtana but I’ve never seen these trials. Would love some input on them if you’ve got some expertise to lend!!
With Zytiga losing efficacy, we have choices ahead of us:
Xofigo
, Jevtana, or three different clinical trials. I feel knowledgeable about the risks and benefits of
Xofigo
and Jevtana but I’ve never seen these trials. Would love some input on them if you’ve got some expertise to lend!!
Nettie8200
in
Advanced Prostate Cancer
4 years ago
Cart-T trial
My PSA is up to 253 after 3 rounds of
Xofigo
. Doc suggests that I do one more, then do a more aggressive treatment . It shows great promise, any thoughts? I can have it right here in Denver.
My PSA is up to 253 after 3 rounds of
Xofigo
. Doc suggests that I do one more, then do a more aggressive treatment . It shows great promise, any thoughts? I can have it right here in Denver.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
REGN 5678 Trial
Hi folks, I have posted in a few other discussions on this board, but I wanted to find out if anyone has experienced or has an opinion about this trial: https://clinicaltrials.gov/ct2/show/NCT03972657 I have gone the gamut, from Docetaxel to Xtandi to Cabazitaxel to
Xofigo
, with 2 clinical trials with
Hi folks, I have posted in a few other discussions on this board, but I wanted to find out if anyone has experienced or has an opinion about this trial: https://clinicaltrials.gov/ct2/show/NCT03972657 I have gone the gamut, from Docetaxel to Xtandi to Cabazitaxel to
Xofigo
, with 2 clinical trials with
tomtom9148
in
Advanced Prostate Cancer
4 years ago
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Update after 3rd Lu177
Fyi, actinium is not available here in the Philippines and i believe
Xofigo
as well when I asked our MO. MO wants us to submit a tissue sample from biopsy procedure taken back in 2018 to Foundation medicine in the US to have genomic profiling done and that will take 2-3wks.
Fyi, actinium is not available here in the Philippines and i believe
Xofigo
as well when I asked our MO. MO wants us to submit a tissue sample from biopsy procedure taken back in 2018 to Foundation medicine in the US to have genomic profiling done and that will take 2-3wks.
dvcarola2
in
Advanced Prostate Cancer
4 years ago
Low PSA increased Mets
Oncologist recommend adding
Xofigo
-Radium 223. Also going to MD Anderson in Houston. Interested in the groups thoughts? Continuing to be positive and praying for each of you daily.
Oncologist recommend adding
Xofigo
-Radium 223. Also going to MD Anderson in Houston. Interested in the groups thoughts? Continuing to be positive and praying for each of you daily.
BigTex3
in
Advanced Prostate Cancer
4 years ago
New Trial of Lu-177-PSMA-617 to begin April 30, 2021.
Xofigo
is allowed if it was used more than 6 months ago. Treatment with and resistance to at least one advanced hormonal therapy is required. Participants must have progressive metastatic castration-resistant PC.
Xofigo
is allowed if it was used more than 6 months ago. Treatment with and resistance to at least one advanced hormonal therapy is required. Participants must have progressive metastatic castration-resistant PC.
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Provenge Failed
Additionally, I talked to the RO who believes
XOFIGO
will be difficult to tolerate because of the MDS problem. Additionally, because of these other conditions have been advised I will not be accepted in any clinical trials.
Additionally, I talked to the RO who believes
XOFIGO
will be difficult to tolerate because of the MDS problem. Additionally, because of these other conditions have been advised I will not be accepted in any clinical trials.
Bigpike
in
Advanced Prostate Cancer
4 years ago
PSA up to 112, Xofigo treatment now
It’s been a long haul and I am looking for next steps after
Xofigo
. Provenge is not an option at this point, insurance will not approve it at this point. I am open to suggestions at this point.
It’s been a long haul and I am looking for next steps after
Xofigo
. Provenge is not an option at this point, insurance will not approve it at this point. I am open to suggestions at this point.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
Suggestions on next step of therapy
Xofigo
also, although my pain level is minimal. I've done genetic testing and no genetic issues were detected. I see my MO on the 23rd and want to be prepared with all the knowledge I can bring to the table. Any ideas or suggestions will be greatly appreciated.
Xofigo
also, although my pain level is minimal. I've done genetic testing and no genetic issues were detected. I see my MO on the 23rd and want to be prepared with all the knowledge I can bring to the table. Any ideas or suggestions will be greatly appreciated.
Kentucky1
in
Advanced Prostate Cancer
4 years ago
Beef & Mushrooms in a cream sauce over noodles....and Lu-177 thoughts...plus FoundationOne Testing
I'm facing the oncologist telling me that I need to decide between 3 or 4 really bad sounding options....Chemo for life...Radium 223...
Xofigo
...and I have added in the option of Lu-177. My PSA is doubling EVERY month lately ...and is up to 48.
I'm facing the oncologist telling me that I need to decide between 3 or 4 really bad sounding options....Chemo for life...Radium 223...
Xofigo
...and I have added in the option of Lu-177. My PSA is doubling EVERY month lately ...and is up to 48.
greatjohn
in
Advanced Prostate Cancer
4 years ago
XOFIGO ? Ra-223...Is it worth it ??
Xofigo
is very expensive ($70,000 for six doses) and its efficiency is somewhat questionable.
Xofigo
is very expensive ($70,000 for six doses) and its efficiency is somewhat questionable.
Fairwind
in
Advanced Prostate Cancer
4 years ago
PT-112 study
Ok, after many standard of care options (Lupron, docetaxel, Xtanti,
Xofigo
) and 2 clinical trials, this one looks like a good next step. My PSA has ballooned up to 175, but I am stills mostly asymtomatic with Mets in 4 bones.
Ok, after many standard of care options (Lupron, docetaxel, Xtanti,
Xofigo
) and 2 clinical trials, this one looks like a good next step. My PSA has ballooned up to 175, but I am stills mostly asymtomatic with Mets in 4 bones.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
Keeping my arms, legs, hands and feet inside the ride
They denied i the combo(much to the chagrin of my MO) but approved
Xofigo
. Did one infusion Sept 28. Then my MO called and we discussed. Going to do 4 rounds cabazitaxel starting Oct 23 and hold off on
Xofigo
for now. We are looking at the systemic treatment to reset baseline.
They denied i the combo(much to the chagrin of my MO) but approved
Xofigo
. Did one infusion Sept 28. Then my MO called and we discussed. Going to do 4 rounds cabazitaxel starting Oct 23 and hold off on
Xofigo
for now. We are looking at the systemic treatment to reset baseline.
Maleko808
in
Advanced Prostate Cancer
4 years ago
CRPC at 58 - next step
Zytiga / Yonsa vs
Xofigo
are really the two ones I’m expecting. My questions: 1.I’m CRPC now at this point. Extensive bone Mets in my history but resolved from chemo. If bone Mets are back, should I do
Xofigo
first? Any studies done waiting to do zytiga or
xofigo
in any order? 2. Zytiga vs Yonsa?
Zytiga / Yonsa vs
Xofigo
are really the two ones I’m expecting. My questions: 1.I’m CRPC now at this point. Extensive bone Mets in my history but resolved from chemo. If bone Mets are back, should I do
Xofigo
first? Any studies done waiting to do zytiga or
xofigo
in any order? 2. Zytiga vs Yonsa?
BigM62
in
Advanced Prostate Cancer
4 years ago
Whats after docetaxol and how much time
We have done Lupron pretty much continuously, removed prostate, radiation to area, Zytiga with Prednisone,
Xofigo
, and now Docetaxol. His PSA is over 2000. He is in pain everywhere....I am very scared. His children (my step children) dont seem to get it. He is walking with a walker.
We have done Lupron pretty much continuously, removed prostate, radiation to area, Zytiga with Prednisone,
Xofigo
, and now Docetaxol. His PSA is over 2000. He is in pain everywhere....I am very scared. His children (my step children) dont seem to get it. He is walking with a walker.
lovemyhusband4945
in
Advanced Prostate Cancer
4 years ago
Wedding Cake, PSA rising and Scans showing a bunch more spots on bones all over.
More radiation via Radium 223 (
Xofigo
) door # 3. something experimental/in trial/etc. door # 4. She's getting back with me next week after research. None of my options sound so great. I iced my hands and feet during chemo and hated it...and it sucks.
More radiation via Radium 223 (
Xofigo
) door # 3. something experimental/in trial/etc. door # 4. She's getting back with me next week after research. None of my options sound so great. I iced my hands and feet during chemo and hated it...and it sucks.
greatjohn
in
Advanced Prostate Cancer
4 years ago
Next Steps after Cabazitaxel and Xtandi
My Oncologist, Alexander Menter in Denver, is giving me these options: "I think
Xofigo
, carboplatin, Taxotere, mitoxantrone, and revisiting trials are all good options. " Any suggestions?
My Oncologist, Alexander Menter in Denver, is giving me these options: "I think
Xofigo
, carboplatin, Taxotere, mitoxantrone, and revisiting trials are all good options. " Any suggestions?
tomtom9148
in
Advanced Prostate Cancer
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
XOFIGO
® (radium Ra 223 dichloride) injection, for intravenous use [prescribing information]: Bayer HealthCare Pharmaceuticals Inc.; 2013. 106. XTANDI® (enzalutamide) [prescribing information]: Astellas Pharma Inc.; 2012. 107. Ning YM, Brave M, Maher VE, et al. U.S.
XOFIGO
® (radium Ra 223 dichloride) injection, for intravenous use [prescribing information]: Bayer HealthCare Pharmaceuticals Inc.; 2013. 106. XTANDI® (enzalutamide) [prescribing information]: Astellas Pharma Inc.; 2012. 107. Ning YM, Brave M, Maher VE, et al. U.S.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Is Xofigo a good option for extensive skeletal mets?
What about
Xofigo
as a next step? My MO did not mention it and just wants to keep me on Firmagon and see how things go. Any thoughts?
What about
Xofigo
as a next step? My MO did not mention it and just wants to keep me on Firmagon and see how things go. Any thoughts?
Pianodude
in
Advanced Prostate Cancer
4 years ago
Current status of immune therapy
Several years ago it was prominent in the news; now seldom mentioned other than
Xofigo
which is not a primary treatment, but rather palliative for pain.
Several years ago it was prominent in the news; now seldom mentioned other than
Xofigo
which is not a primary treatment, but rather palliative for pain.
Shepard
in
Advanced Prostate Cancer
4 years ago
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