Cart-T trial

[tomtom9148]

My PSA is up to 253 after 3 rounds of Xofigo. Doc suggests that I do one more, then do a more aggressive treatment . It shows great promise, any thoughts? I can have it right here in Denver.

[Tall_Allen]

Which CAR-T trial?

[Bob10 in reply to Tall_Allen]

Yes which car-t please

[tomtom9148]

P-PSMA 101 Cart-T cells, NC04249947. I can’t seem to paste on here from my phone. Poseida Therapy , at Sarah Cannon in Denver

[Tall_Allen in reply to tomtom9148]

Let us know how it goes.

[6357axbz in reply to tomtom9148]

Can’t find anything under that trial number

[tomtom9148]

clinicaltrials.gov/ct2/show...

[tango65]

Some info about this treatment:

biospace.com/article/fda-ha....

cancernetwork.com/view/fda-...

[Patrick-Turner]

To be able to comment on your situation, you need to post a lot more on your history so far with Pca and the Psa numbers and dates et all.I am considering Xofigo, ie, Ra223 soon, so I am very interested in what is really happening with you.

Patrick Turner.

[tomtom9148 in reply to Patrick-Turner]

Hi Patrick, my history is long and sordid, lol. Diagnosed with mPc in May of 2016 with PSA of 16 and Gleason 9/10, Lupron, the trial of Docetaxel and PROSTVAC at NIH. PSA went way down, Mets stable for 1-1/2 years. November of 2017 PSA up to 2.6 and new Mets. Went on St of care with Xtandi for 2 years, PSA reduced again. It rose back up in November of 2019, switched to Zytiga for 3 months with no improvement. Trial at Sarah Cannon with ADZ 4635 and Oleculab from 2/20-5/20, not much change and PSA up to 20. Went back to Kaiser (Denver) for Cabaxetaxel , no charge and increasing PSA after 3 infusions. Tried Xtandi again, no reduction in PSA. Started Xofigo in October of 2020, PSA up to 270 after 3 infusions, but Catscan showed that treatment is acting on Bone Mets and no progression of disease. We are worried about rising PSA and want to reduce it. I will do one more Xofigo next week (#4), then look into Cart-T PSMA. Mets in L2, S2, T6, and 3rd rib, no lymph nodes . My Doc assures me that benefits far outweigh the risk. I am asymptomatic and fairly healthy, fatigue , nausea, and other side effects notwithstanding.

[mikell in reply to tomtom9148]

I finished a round of Xofigo almost 2 months ago. In early March 2020 my PSA was 8. By June, just before Xofigo it was 70 with ALK 215. Bone Mets in spine, shoulders and ribcage hurting. Just 5 days after Xofigo, PSA jumped to 99, ALK first jumped to 227 then started dropping. Two months after starting Xofigo, ALK dropped to 102 and 3 months in to 73. ALK bounced around that area during the rest of Xofigo (with the PSA constantly rising) until now, at 550, two months after finishing Xofigo. ALK has started climbing again also, now at 91. Xofigo Dr said to pay no attention to rising PSA during treatment and afterward. Well, I'm concerned and now feel I have to have chemo or immunotherapy if possible. PSA of 550. Current CT Scan and MRI show many new lesions since last scan over a year ago. Xofigo dr says they might have been new since before the Xofigo and could be sclerosis (bone scarring) after Xofigo, and not new active cancer. A PET scan would tell more but he says it may show false positives after Xofigo. I don't yet know when a PET scan would be effective. The CT and MRI seem to show no soft tissue involvement. But . . . where the hell is the PSA coming from if not new bone involvement, even now, 2 months after Xofigo. Maybe new bone lesions are exploding 2 months after Xofigo. And I certainly should have mentioned I was diagnosed with MPCA in Nov 2016 and have been on ADT ever since, Lupron, Firmagon and now Zoladex and seem obviously Castrate Resistant. Wonder about BAT.

[j-o-h-n]

Beat that tomtom and let us know how ya doing? Smoke signals not legal.....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 01/07/2021 10:03 PM EST- All Greeks named John today is their nameday

[drmoose]

PSMA is a pretty good biomarker of prostate cancer cells. But other cells express it too en.wikipedia.org/wiki/Gluta... . Ask them how they distinguish the PSMA-expressing PCa from the other healthy cells ... (okay that is a "tough" question but at least they know you are paying attention ) This probably relates to anticipated potential side effects e.g. "toxicities".

In any case - all the best!

[tomtom9148]

Now they are moving me towards a RGEN 5678 trial, PSMA. They called yesterday and want to know by Monday (1/11). The Cart-t trial wouldn’t start till March with blood draw, reinfusion 6 weeks later. Risky, is it worth it?

[tomtom9148]

clinicaltrials.gov/ct2/show...

[Hotrod65]

My understanding is CAR-T .. Chimeric Androgen Receptor T cell is a treatment being used for Blood Cancers presently..not heard of any Prostate Trials currently?.. please provide more info?.

[tomtom9148 in reply to Hotrod65]

Yes, in Colorado, Massachusetts, New York and California. Click link above to view

[Hotrod65]

We are close to initiating a CAR T cell clinical trial for patients with advanced prostate adenocarcinoma that was developed here and also funded by PCF. The successful completion of this new project will identify another unique CAR T cell for the lethal neuroendocrine subtype of prostate cancer, and we envision these two clinical programs will increase the number of patients with advanced disease that may benefit from CAR T cell therapy in the near future."

Pre clinical trials for scNEPC.. Neuroendocrine differentiation currently..the disease I have and currently in Complete Durable Clinical Remission NED due to effective use of checkpoint inhibitors Immunotherapy.