Experiences with

Xgeva

Does anyone else get their Xgeva as an IM injection?

Currently on Ibrance, letrozole, and Xgeva. Have all the usual suspects for side effects, but doing okay - still mobile, still engaged. Hope you all are staying safe in these crazy times and I look forward to getting to know you. Aquadog

My docs are hitting me with Lupron/Zytiga, Provenge, SBRT to the bone mets, Xgeva, and eventually Docetaxel and Xofigo.

Started on lupron/abiraterone/prednisone and Xgeva infusions every 3 months. PSA lowered to 63.6 then 38.9 to 1.2 in December. PSA was 1.6 in January, 2.4 in February and 14.1 in May. Doctor wants to change from abiraterone to Xtandi. Has anyone had success with Xtandi?

So I'm going to start bone strengthening injections-it will either be Zometa or Xgeva. I'm just wondering what anyone's experiences been with either of these drugs. As always I appreciate all of your help and expertise! Aimee

I am on Arimidex, Kisqali, Xgeva and remain NED so far. My MO is checking PET scans every 3 months and TMs monthly. My CA15-3 was normal at diagnosis, bumped up to a peak of high 30s during treatment and now back down to 20s. I am doing great now almost at 15 months!!!

I have been on Lupron for 25 months now...and Xgeva for almost as long. When I complained about bone pain/weakness/fatigue/hot flashes/etc....today he looked at me and said "didn't the other oncologist tell you when you started about the effects of long-term use of these treatments?

It shows C-Terminal Telopeptide (a blood marker of bone turnover) dropping 90% and staying down for over 120 days after a single dose, and the same effect was seen for both 60 mg (Prolia) and 120 mg (Xgeva) doses.

Still on Lupron and Xgeva. Second cabazitaxel delayed a week due to high AST. Alkaline phosphatase is 379; current AST 93. PSA 46. He's anemic; WBC okay. Foundation One tests showed ROS1 fusion in liquid biopsy, not confirmed in solid; FMI is working with me on this.

He’s still on Lupron, getting Xgeva, and weaning off Prednisone. PSAs since 10/2019: .66 .69 .77 (chemo started) .60 .51 .39 .32 ALPs since 8/2019: 173, 42, 42, 39, 40, 39 SCANS: 10/21/19 right before chemo: Bone scan: "Appearance generally similar to 8/19 scans.”

Doctor says this is a GOOD result...just going to be staying the course with Lupron and Xtandi...and I get to drop the Xgeva...ALREADY after two months off my bone pain is almost completely gone. She's mentioned "ball removal" and I'm thinking about it.

My question is what have been any of your experiences with Xgeva, and what was your dental situation? Thank you for any help in making this decision.

Potential Xgeva side effects include pain in these areas . Has anyone else experienced this? Thanks Bob

It's been almost three years battling the Beast and my treatments have been Zytiga, Xgeva, Eligard, and Provenge infusions still on them and don't intend to change unless Doc says so. Never give up never surrender. Leo

From the start of stage 4 diagnosis in 2018, husband did Zytiga, Docetaxel and then back to Zytiga along with Xgeva and Eligard. PSA went down to as much as 0.34 in Oct 2019 after 6 cycles of Docetaxel which he tolerated fairly well.

Takes flomax daily, erleada daily, shots of Lupron and Xgeva every 3 months. His biggest complaint is not fully emptying his bladder and how long it takes to get the flow. He doesn’t sleep more then 2 hours at a time. He is afraid to self-catheter because of infection or puncture.

I have been stable almost 2 years on Ibrance, Letrazole and Xgeva. My latest bone scan is stable. The CT showed that a "shadow" in my liver grew about 1cm (previous 7 tumors are gone). My Oncologist wants to change me to Piquray and Fuvestrant, because I have the mutation.

IF I should start.. any reason that it should be Prolia and not Xgeva? NB: I fought myself into getting a PSMA PET/CT scan 2.5 months after radiation (which is in 5 weeks from now) to see the current state and effect of radiation (to bone mets).. Also had one for diagnosis...

"Have you been switched to 3 month Xgeva injections. Am I just offering up a tempest in a tea cup?" By the way, I've never had a bone density test in the three years I've been playing this game of blind man's bluff. Thank you, Toothless in Seattle.

I’ve been on xgeva monthly for years then switched to guarterly about a year ago. I’ve been having these issues which as I read about xgeva I wonder if I should go on a vacation: numbness in toes and soles of feet, pain in groin , back pain, unsteadiness . My bone mass scans have been normal.