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Venetoclax
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Frontline treatment of Chronic Lymphocytic Leukemia (CLL/SLL) in 2021
Given high response rates with ibrutinib, acalabrutinib, and
venetoclax
, there is no one clearly superior strategy or one-size-fits-all approach.
Given high response rates with ibrutinib, acalabrutinib, and
venetoclax
, there is no one clearly superior strategy or one-size-fits-all approach.
CLLerinOz
Administrator
in
CLL Support
3 years ago
Venetoclax
Well, I started
Venetoclax
just over 2 weeks ago and can’t believe how well I feel with no side effects at all so far. I will have 6 rounds of Rituximab starting in a couple of months.
Well, I started
Venetoclax
just over 2 weeks ago and can’t believe how well I feel with no side effects at all so far. I will have 6 rounds of Rituximab starting in a couple of months.
Racing1961
in
CLL Support
3 years ago
Suspending Ibrutinib
I am in the UK and Ipresently take Ibrutinib and
Venetoclax
as treatment for CLL however I have received a call from my hematologist saying that because I am on medication for blood pressure I should cease taking the Ibrutinib and wait for further updates. Has anyone else received a call?
I am in the UK and Ipresently take Ibrutinib and
Venetoclax
as treatment for CLL however I have received a call from my hematologist saying that because I am on medication for blood pressure I should cease taking the Ibrutinib and wait for further updates. Has anyone else received a call?
GreyB
in
CLL Support
3 years ago
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Concerns about the level of protection of Covid vaccine while on Obinutuzimab and Venetoclax.
Hi I have recently had my last infusion of Obinutuzimab, and am taking 300g
Venetoclax
daily. I still haven't decided whether to have the covid vaccine.
Hi I have recently had my last infusion of Obinutuzimab, and am taking 300g
Venetoclax
daily. I still haven't decided whether to have the covid vaccine.
Leilalala
in
CLL Support
3 years ago
Treatment advised (after 21 years w & w)
I told hospital (Royal Marsden) I wasn't keen on FCR, so was offered a choice of (1) Obinutuzumab plus
Venetoclax
or (2) Acalabrutinib. I was also given a leaflet on Rituxan but I am not sure how this would fit in (could it be combined with
Venetoclax
as a first-line treatment in the UK?)
I told hospital (Royal Marsden) I wasn't keen on FCR, so was offered a choice of (1) Obinutuzumab plus
Venetoclax
or (2) Acalabrutinib. I was also given a leaflet on Rituxan but I am not sure how this would fit in (could it be combined with
Venetoclax
as a first-line treatment in the UK?)
ornstin
in
CLL Support
3 years ago
Have you relapsed on, or become refractory to a Btki drug such as ibrutinib, or the bcl-2i venetoclax?
Have you relapsed on, or become refractory to a Btki drug such as ibrutinib, or the bcl-2i
venetoclax
? These drugs have radically improved how CLL is treated.
Have you relapsed on, or become refractory to a Btki drug such as ibrutinib, or the bcl-2i
venetoclax
? These drugs have radically improved how CLL is treated.
bkoffman
CLL CURE Hero
in
CLL Support
3 years ago
From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL
The 4-year OS rate was 85.3% in the
venetoclax
arm and 83.1% in the chlorambucil arm (HR, 0.85; 95% CI, 0.54-1.35; P =.49). Second primary malignancies were seen in 40 patients in the
venetoclax
arm and 30 in the chlorambucil arm.
The 4-year OS rate was 85.3% in the
venetoclax
arm and 83.1% in the chlorambucil arm (HR, 0.85; 95% CI, 0.54-1.35; P =.49). Second primary malignancies were seen in 40 patients in the
venetoclax
arm and 30 in the chlorambucil arm.
Jm954
Administrator
in
CLL Support
3 years ago
Long-Term Data Showcase the Clinical Utility of Fixed-Duration Venetoclax/Obinutuzumab in Treatment-Naïve CLL
What do these data suggest in terms of the clinical utility of
venetoclax
/obinutuzumab in this patient population? The data suggest that a frontline approach with
venetoclax
and obinutuzumab is very feasible and effective for an elderly patient population [with CLL].
What do these data suggest in terms of the clinical utility of
venetoclax
/obinutuzumab in this patient population? The data suggest that a frontline approach with
venetoclax
and obinutuzumab is very feasible and effective for an elderly patient population [with CLL].
lankisterguy
Volunteer
in
CLL Support
3 years ago
Frontline Ibrutinib/Venetoclax Elicits Durable Responses in CLL With Undetectable MRD
reported July 13, 2021 by Courtney Marabella https://www.onclive.com/view/frontline-ibrutinib-
venetoclax
-elicits-durable-responses-in-cll-with-undetectable-mrd Fixed-duration ibrutinib (Imbruvica) plus
venetoclax
(Venclexta) produced superior progression-free survival (PFS) when compared with chlorambucil
reported July 13, 2021 by Courtney Marabella https://www.onclive.com/view/frontline-ibrutinib-
venetoclax
-elicits-durable-responses-in-cll-with-undetectable-mrd Fixed-duration ibrutinib (Imbruvica) plus
venetoclax
(Venclexta) produced superior progression-free survival (PFS) when compared with chlorambucil
lankisterguy
Volunteer
in
CLL Support
3 years ago
3rd Covid shot while still receiving (O & V)?
I have read that taking and while taking
venetoclax
greatly reduces the response to the Covid vaccine to only about 15%. Does anyone have experience taking a 3rd covid vaccine (perhaps J & J) to boost this currently, probably low response?
I have read that taking and while taking
venetoclax
greatly reduces the response to the Covid vaccine to only about 15%. Does anyone have experience taking a 3rd covid vaccine (perhaps J & J) to boost this currently, probably low response?
ronsolo306
in
CLL Support
3 years ago
Treatment and ocular lymphocytic leukemia
My diagnosis in 2017Trisomy12 unmutated 500000 wbc 397 absolute lymphocite Count 6.1 hemoglobin I joined a threefold trial Ibrutinib, Obinutuzumab and
Venetoclax
. When I had uveitis on both eyes I felt it was temporarily but treatment was necessary.
My diagnosis in 2017Trisomy12 unmutated 500000 wbc 397 absolute lymphocite Count 6.1 hemoglobin I joined a threefold trial Ibrutinib, Obinutuzumab and
Venetoclax
. When I had uveitis on both eyes I felt it was temporarily but treatment was necessary.
mickimauser11
in
CLL Support
3 years ago
Weight gain on Venetoclax
Has anybody noticed weight gain whilst on a
Venetoclax
, I lost 10.5 stone some years ago and had managed to maintain a healthy weight but since taking
Venetoclax
I’m slowly putting in weight.
Has anybody noticed weight gain whilst on a
Venetoclax
, I lost 10.5 stone some years ago and had managed to maintain a healthy weight but since taking
Venetoclax
I’m slowly putting in weight.
2gizzy
in
CLL Support
3 years ago
Lisaftoclax yet another and seemingly better drug
This seems to be better tolerated than
venetoclax
so hopefully will be available to all in the not too distant future
This seems to be better tolerated than
venetoclax
so hopefully will be available to all in the not too distant future
Research123
in
CLL Support
3 years ago
O&V
My partner has just commence his
venetoclax
10mg last week up to now all good side effect wise , his obinutuzumab will go to monthly infusion now , anyone had side effects of
venetoclax
once start ramp up Thanks in advance first line treatment so all new to us and he did have to episode with his first
My partner has just commence his
venetoclax
10mg last week up to now all good side effect wise , his obinutuzumab will go to monthly infusion now , anyone had side effects of
venetoclax
once start ramp up Thanks in advance first line treatment so all new to us and he did have to episode with his first
Hd07
in
CLL Support
3 years ago
Relapsing on Ibrutinib
One is
Venetoclax
and Rituxan, the alternative is a clinical trial with MK1026. Had anyone heard about this new drug (BTK inhibitor), by any chance? I have faith in you!
One is
Venetoclax
and Rituxan, the alternative is a clinical trial with MK1026. Had anyone heard about this new drug (BTK inhibitor), by any chance? I have faith in you!
Doremefasol
in
CLL Support
3 years ago
Working, CLL and Covid
I'm on
Venetoclax
but doing very well and I'm vaccinated. Thank you.
I'm on
Venetoclax
but doing very well and I'm vaccinated. Thank you.
Kenn123
in
CLL Support
3 years ago
Clinical trial for waldenstrom
I started a clinical trial of two oral meds this week: ibrutinib and
venetoclax
. Dana farber is running the 50 person trial. They’re powerful, targeted meds to knock down the cancer.
I started a clinical trial of two oral meds this week: ibrutinib and
venetoclax
. Dana farber is running the 50 person trial. They’re powerful, targeted meds to knock down the cancer.
waer88
in
CLL Support
3 years ago
Captivate Trial MRD status
My treatment ended in May 2019....Ibrutinib for 12 months and
Venetoclax
for 9. I just received several test results including Flow Citometry and I am still MRD negative after 2 years. This trial was simply awesome and a life saver.
My treatment ended in May 2019....Ibrutinib for 12 months and
Venetoclax
for 9. I just received several test results including Flow Citometry and I am still MRD negative after 2 years. This trial was simply awesome and a life saver.
lamboman
in
CLL Support
3 years ago
CLL Society COVID-19 guidelines, & Explaining to Family and Friends Why the CDC Guidelines for Those Vaccinated - Do Not Apply to us
Davids Discusses Duvelisib and
Venetoclax
, an Oral Time-Limited Treatment for Chronic Lymphocytic Leukemia (CLL).
Davids Discusses Duvelisib and
Venetoclax
, an Oral Time-Limited Treatment for Chronic Lymphocytic Leukemia (CLL).
lankisterguy
Volunteer
in
CLL Support
3 years ago
Hi All . Anyone been having weekend away while on Venetoclax for breaks in UK
Just me and partner and thinking of short break away and just wondered if anyone has been still travelling with COVID numbers so high
Just me and partner and thinking of short break away and just wondered if anyone has been still travelling with COVID numbers so high
Hd07
in
CLL Support
3 years ago
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