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Experiences with
Obinutuzumab
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Week 2 Obinutuzumab
Today was week 2 & I had my second 1000 ml transfusion of
Obinutuzumab
. It is 11 .30 pm U.K. time ; I am still up and have energy despite having spent 8+ hours in hospital today. I then came home , cooked , cleaned and washed up , relaxed a bit, messaged friends .....
Today was week 2 & I had my second 1000 ml transfusion of
Obinutuzumab
. It is 11 .30 pm U.K. time ; I am still up and have energy despite having spent 8+ hours in hospital today. I then came home , cooked , cleaned and washed up , relaxed a bit, messaged friends .....
RitaBa
in
Leukaemia Support
4 years ago
LLS Covid-19 Vaccine Trial: Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies
[/i] [i]The numbers were small, but patients who received anti-CD19 CAR-T therapy that is used in CLL or anti-CD20 monoclonal antibodies (rituximab and
obinutuzumab
) in the last year respond poorly to vaccination.
[/i] [i]The numbers were small, but patients who received anti-CD19 CAR-T therapy that is used in CLL or anti-CD20 monoclonal antibodies (rituximab and
obinutuzumab
) in the last year respond poorly to vaccination.
lankisterguy
Volunteer
in
CLL Support
3 years ago
RLS and CLL
I am currently in a clinical trial for CLL, taking Ibrutinib and
Obinutuzumab
, and I am wondering if anyone else in this community shares my situation dealing with RLS (an incurable syndrome) and the drugs treat and mistreat it. I apologize for not putting my earlier request in context.
I am currently in a clinical trial for CLL, taking Ibrutinib and
Obinutuzumab
, and I am wondering if anyone else in this community shares my situation dealing with RLS (an incurable syndrome) and the drugs treat and mistreat it. I apologize for not putting my earlier request in context.
loflash
in
CLL Support
4 years ago
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NICE Recommends Acalabrutinib for treating CLL for certain groups
If FCR or BR is unsuitable, chlorambucil plus
obinutuzumab
is offered instead. Clinical trial evidence in this group shows that CLL takes longer to progress when treated with acalabrutinib compared with chlorambucil plus
obinutuzumab
. However, the overall survival benefit is uncertain.
If FCR or BR is unsuitable, chlorambucil plus
obinutuzumab
is offered instead. Clinical trial evidence in this group shows that CLL takes longer to progress when treated with acalabrutinib compared with chlorambucil plus
obinutuzumab
. However, the overall survival benefit is uncertain.
Jm954
Administrator
in
CLL Support
3 years ago
Aggressive CLL - Richter's Transformation
The first-line treatment was
obinutuzumab
/venetoclax but after a year on this treatment, his disease has turned to a Richter's Transformation (large cell lymphoma).
The first-line treatment was
obinutuzumab
/venetoclax but after a year on this treatment, his disease has turned to a Richter's Transformation (large cell lymphoma).
Phs2385
in
CLL Support
3 years ago
Clinical trial with Acalabrutinib and Obinutuzumab
The targeted therapy is Acalabrutinib and
Obinutuzumab
. I would appreciate hearing from people that have had these two drugs. What was your experience? I am struggling with the decision of whether to participate in the trial. Thanks.
The targeted therapy is Acalabrutinib and
Obinutuzumab
. I would appreciate hearing from people that have had these two drugs. What was your experience? I am struggling with the decision of whether to participate in the trial. Thanks.
Reflectionofsky
in
CLL Support
4 years ago
Acalabrutinib Plus Obinutuzumab Prolongs Progression Free Survival Compared to Other Targeted Agents in Chronic Lymphocytic Leukaemia (CLL)
[i]First-line acalabrutinib plus
obinutuzumab
prolongs progression-free survival (PFS) compared to ibrutinib-
obinutuzumab
and venetoclax-
obinutuzumab
for patients with chronic lymphocytic leukemia (CLL), according to a study published in Clinical Lymphoma, Myeloma, & Leukemia (2020 Oct 29;S2152-2650(
[i]First-line acalabrutinib plus
obinutuzumab
prolongs progression-free survival (PFS) compared to ibrutinib-
obinutuzumab
and venetoclax-
obinutuzumab
for patients with chronic lymphocytic leukemia (CLL), according to a study published in Clinical Lymphoma, Myeloma, & Leukemia (2020 Oct 29;S2152-2650(
AussieNeil
Partner
in
CLL Support
4 years ago
DLBCL or B-PLL
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Phs2385
in
Non Hodgkin's Lymphoma Friends
3 years ago
B-PLL or DLBCL
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Phs2385
in
CLL America Support
3 years ago
B-PLL/DLBCL
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Hi Everyone, My dad was on
obinutuzumab
/venetoclax combination first-line treatment for CLL with aggressive features. The CLL is out of his blood, but lymphoma is now in his femur and kidney region.
Phs2385
in
CLL Support
3 years ago
Just a little update :)
I completed the
Obinutuzumab
in October, and was finally taken off Allopurinol and antibiotics in December (and immediately lost 4 of the kilos I gained, though it's hard to say if it was a side effect or just the result of all the cheese I ate around the holidays).
I completed the
Obinutuzumab
in October, and was finally taken off Allopurinol and antibiotics in December (and immediately lost 4 of the kilos I gained, though it's hard to say if it was a side effect or just the result of all the cheese I ate around the holidays).
jijic
in
CLL Support
4 years ago
Side effects of venetoclax combined with obinutuzumab
Hi, I live in the UK and am eligible for venetoclax combined with
obinutuzumab
as first line treatment. I have been on W&W for about 4 years and now as my glands and spleen have been growing (no B symptoms though) I have been offered this treatment. I am due to start in March.
Hi, I live in the UK and am eligible for venetoclax combined with
obinutuzumab
as first line treatment. I have been on W&W for about 4 years and now as my glands and spleen have been growing (no B symptoms though) I have been offered this treatment. I am due to start in March.
Leilalala
in
CLL Support
4 years ago
Living in the USA with CLL and want to know where to sign up for your COVID-19 Vaccination? A State-by-State List
If you are in treatment, or have had treatment with Rituximab,
Obinutuzumab
, Ofatumumab or other anti-CD20 monoclonal antibodies within the past 6 months, you are less likely to produce an antibody response to a vaccination, but it is expected that you will still develop some T-cell based immunity response
If you are in treatment, or have had treatment with Rituximab,
Obinutuzumab
, Ofatumumab or other anti-CD20 monoclonal antibodies within the past 6 months, you are less likely to produce an antibody response to a vaccination, but it is expected that you will still develop some T-cell based immunity response
AussieNeil
Partner
in
CLL Support
4 years ago
BTK inhibitors for the treatment of CLL - the current state of play of 'brutinibs'
If I felt like there was a patient for [whom] I didn’t want to give a BTK inhibitor—and I’ve already stated that I can hardly think of what that setting would be—but if I did give them venetoclax-
obinutuzumab
, I’m not sure I would stop at 1 year. I might leave them on continuous therapy.
If I felt like there was a patient for [whom] I didn’t want to give a BTK inhibitor—and I’ve already stated that I can hardly think of what that setting would be—but if I did give them venetoclax-
obinutuzumab
, I’m not sure I would stop at 1 year. I might leave them on continuous therapy.
CLLerinOz
Administrator
in
CLL Support
3 years ago
Scottish Medicines Agency has decided in favour of Venetoclax plus Obintuzumab for some patients.
The SMC has accepted venetoclax in combination with
obinutuzumab
for use in certain patients.
The SMC has accepted venetoclax in combination with
obinutuzumab
for use in certain patients.
Jm954
Administrator
in
CLL Support
4 years ago
NICE Approves Acalabrutinib (Calquence) for specified groups of CLL patients in England
The main clinical trial evidence that AZ presented to NICE came from the ELEVATE clinical trial, which compared Acalabrutinib (+/-
obinutuzumab
) with a combination of chlorambucil and obintizumab.
The main clinical trial evidence that AZ presented to NICE came from the ELEVATE clinical trial, which compared Acalabrutinib (+/-
obinutuzumab
) with a combination of chlorambucil and obintizumab.
Jm954
in
Leukaemia Support
4 years ago
NICE Approves Acalabrutinib (Calquence) for specified groups of CLL patients in England
The main clinical trial evidence that AZ presented to NICE came from the ELEVATE clinical trial, which compared Acalabrutinib (+/-
obinutuzumab
) with a combination of chlorambucil and obintizumab.
The main clinical trial evidence that AZ presented to NICE came from the ELEVATE clinical trial, which compared Acalabrutinib (+/-
obinutuzumab
) with a combination of chlorambucil and obintizumab.
Jm954
Administrator
in
CLL Support
4 years ago
Obinutuzumab and Venetoclax
Just 2 days before my consultation, on this amazing platform, it had confirmed that
Obinutuzumab
and Venetoclax had been approved in UK as a frontline treatment. I started the
obinutuzumab
on Tuesday and they split the first dose into two days.
Just 2 days before my consultation, on this amazing platform, it had confirmed that
Obinutuzumab
and Venetoclax had been approved in UK as a frontline treatment. I started the
obinutuzumab
on Tuesday and they split the first dose into two days.
ALS27
in
CLL Support
4 years ago
Obinutuzumab and Venetoclax cleared for use in UK
If I read this right, it seems that this is the new go-to combination in the UK? I think I read somewhere that this is also sometimes combined with ibrutinib or acalabrutinib? https://www.dailymail.co.uk/health/article-8973227/Thousands-leukaemia-sufferers-spared-chemotherapy-thanks-new-two-one-treatment.html
If I read this right, it seems that this is the new go-to combination in the UK? I think I read somewhere that this is also sometimes combined with ibrutinib or acalabrutinib? https://www.dailymail.co.uk/health/article-8973227/Thousands-leukaemia-sufferers-spared-chemotherapy-thanks-new-two-one-treatment.html
Research123
in
CLL Support
4 years ago
NICE approves venetoclax with obinutuzumab for patients with untreated CLL
This is good news; initially these patients were not being considered in the NICE appraisal, as there was less clinical trial data available about venetoclax and
obinutuzumab
in this population.
This is good news; initially these patients were not being considered in the NICE appraisal, as there was less clinical trial data available about venetoclax and
obinutuzumab
in this population.
HAIRBEAR_UK
in
Leukaemia Support
4 years ago
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