Search
Search
About
Log in
Join
Experiences with
Obinutuzumab
Posts
Communities
357 public posts
Filter results
Results of Phase II Study of Combination Obinutuzumab, Ibrutinib, and Venetoclax in Treatment-Naïve and Relapsed or Refractory CLL
I think the most surprising thing in this report is that not everyone responds - [i]"The overall response rate at that time was 84% in treatment-naïve patients and 88% in relapsed or refractory patients."[/i] A short report here: https://ascopubs.org/doi/full/10.1200/JCO.20.00491 Jackie
I think the most surprising thing in this report is that not everyone responds - [i]"The overall response rate at that time was 84% in treatment-naïve patients and 88% in relapsed or refractory patients."[/i] A short report here: https://ascopubs.org/doi/full/10.1200/JCO.20.00491 Jackie
Jm954
Administrator
in
CLL Support
4 years ago
What is usually first line of treatment?
I was offered trial with 2 options you dont get to pick Ibrutinib,
obinutuzumab
, venetoclax Or Ibrutinib,
obinutuzumab
I am hearing from the group that these are second line of treatment. I have not been treated and my retired doc just recently said I was watch and wait.
I was offered trial with 2 options you dont get to pick Ibrutinib,
obinutuzumab
, venetoclax Or Ibrutinib,
obinutuzumab
I am hearing from the group that these are second line of treatment. I have not been treated and my retired doc just recently said I was watch and wait.
showdog
in
CLL Support
4 years ago
Interesting article on venetoclax, ibrutinib and obinutuzumab combination
https://www.targetedonc.com/view/
obinutuzumab
-triplet-achieves-deep-remissions-in-chronic-lymphocytic-leukemia Interesting article on venetoclax, ibrutinib and
obinutuzumab
combination which seems to be doing a good job
https://www.targetedonc.com/view/
obinutuzumab
-triplet-achieves-deep-remissions-in-chronic-lymphocytic-leukemia Interesting article on venetoclax, ibrutinib and
obinutuzumab
combination which seems to be doing a good job
Research123
in
CLL Support
4 years ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
Interesting article on venetoclax obinutuzumab and Ibrutinib trial
https://www.cancertherapyadvisor.com/home/cancer-topics/chronic-lymphocytic-leukemia/chronic-leukemia-cll-triple-therapy-phase-2-trial
https://www.cancertherapyadvisor.com/home/cancer-topics/chronic-lymphocytic-leukemia/chronic-leukemia-cll-triple-therapy-phase-2-trial
Research123
in
CLL Support
4 years ago
Plural Effusion with CLL
Started clinical trial at Stanford, Ibrutinib and
Obinutuzumab
about week and half ago. WBC was >300 at start now done to 100 and lymph node size decreased significantly! Problem is CT scan showed large plural effusion at start of trial.
Started clinical trial at Stanford, Ibrutinib and
Obinutuzumab
about week and half ago. WBC was >300 at start now done to 100 and lymph node size decreased significantly! Problem is CT scan showed large plural effusion at start of trial.
kubie
in
CLL Support
4 years ago
Richter’s Transformation - Update 27-01-2021
This development happened after I first developed RT on Ibrutinib, then after the relapse I had progression on other combinations of these medications; first I had progression on Venetoclax + Ibrutinb and then progression on Venetoclax + Idelalisib +
Obinutuzumab
.
This development happened after I first developed RT on Ibrutinib, then after the relapse I had progression on other combinations of these medications; first I had progression on Venetoclax + Ibrutinb and then progression on Venetoclax + Idelalisib +
Obinutuzumab
.
Priss69
in
CLL Support
4 years ago
Gazyva/Venclexta
After 2 treatments with
Obinutuzumab
, his numbers have plummeted to within normal range. And his glands are all back to normal size. it is really incredible. He has not started on the Venclexta yet. The doctor is holding off for now because of his results with the infusions.
After 2 treatments with
Obinutuzumab
, his numbers have plummeted to within normal range. And his glands are all back to normal size. it is really incredible. He has not started on the Venclexta yet. The doctor is holding off for now because of his results with the infusions.
gardenman68
in
CLL Support
4 years ago
My "N of 1" trial with Ibrutinib + Idelalisib + Venetoclax that lead to remission of Richter's in three weeks.
First I had
progression on Venetoclax + Ibrutinb
and then
progression on Venetoclax + Idelalisib +
. The dramatic nature of the situation escalated when transplant doctors in Norway decided against a new Transplant and I was only offered Palliative care.
First I had
progression on Venetoclax + Ibrutinb
and then
progression on Venetoclax + Idelalisib +
. The dramatic nature of the situation escalated when transplant doctors in Norway decided against a new Transplant and I was only offered Palliative care.
UniversallyPersonal
in
CLL Support
4 years ago
Younger, Fit Patients With CLL: Goal Remains Undetectable Minimal Residual Disease and Time-Limited Therapy
The MD Anderson group has reported on front-line ibrutinib with venetoclax, with 61% undetectable MRD Venetoclax with
obinutuzumab
achieved 57% MRD in bone marrow in the CLL14 trial, with a 2-year progression-free survival rate of 88.2%.
The MD Anderson group has reported on front-line ibrutinib with venetoclax, with 61% undetectable MRD Venetoclax with
obinutuzumab
achieved 57% MRD in bone marrow in the CLL14 trial, with a 2-year progression-free survival rate of 88.2%.
Jm954
Administrator
in
CLL Support
4 years ago
Anyone have experience with Venclexta capped at 200 mg?
I am a 62 yr old woman and will be starting
Obinutuzumab
in 2 days with Venclexta added my 4th week. I was diagnosed with SLL/CLL May 2019 and was watch and wait until now. It has been confined to my lymph nodes and my blood tests have been in the normal range.
I am a 62 yr old woman and will be starting
Obinutuzumab
in 2 days with Venclexta added my 4th week. I was diagnosed with SLL/CLL May 2019 and was watch and wait until now. It has been confined to my lymph nodes and my blood tests have been in the normal range.
Flute117
in
CLL Support
4 years ago
End of suspense! Here is Dr. Koffman's ASCO 2020 "Top Pick" #1!
Koffman highlights the CLL 14 Trial, a study looking at fixed-duration venetoclax-
obinutuzumab
for previously untreated patients with chronic lymphocytic leukemia (CLL). https://cllsociety.org/2020/08/asco-2020-top-12-1-fixed-duration-venetoclax-
obinutuzumab
-for-previously-untreated-patients-with-chronic-lymphocytic-leukemia-follow-up-of-efficacy-and-safety-results-from-the-multicenter-open
Koffman highlights the CLL 14 Trial, a study looking at fixed-duration venetoclax-
obinutuzumab
for previously untreated patients with chronic lymphocytic leukemia (CLL). https://cllsociety.org/2020/08/asco-2020-top-12-1-fixed-duration-venetoclax-
obinutuzumab
-for-previously-untreated-patients-with-chronic-lymphocytic-leukemia-follow-up-of-efficacy-and-safety-results-from-the-multicenter-open
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
O + V: Update 4!
Anyhow I finished my
Obinutuzumab
infusions in early July. Got to ring a little bell & aww-shucks my way through an embarrassing standing ovation. Kinda cried a little bit too, actually, as I knew I’d really miss the chemo nurses, who were so calmingly attentive.
Anyhow I finished my
Obinutuzumab
infusions in early July. Got to ring a little bell & aww-shucks my way through an embarrassing standing ovation. Kinda cried a little bit too, actually, as I knew I’d really miss the chemo nurses, who were so calmingly attentive.
DRM18
in
CLL Support
4 years ago
Kidney fouling during CLL watch and wait
I did start first-line treatment about a month ago with my first
obinutuzumab
infusion, but had to pause the regimen for hospitalization for neutropenic fever, but I'm recovered now and my creatinine has dropped significantly, perhaps in proportion to the killing off of CLL cells (my ALC dropped from
I did start first-line treatment about a month ago with my first
obinutuzumab
infusion, but had to pause the regimen for hospitalization for neutropenic fever, but I'm recovered now and my creatinine has dropped significantly, perhaps in proportion to the killing off of CLL cells (my ALC dropped from
PhotonPal
in
CLL Support
4 years ago
What infections are likely during neutropenia from mAb's?
Before I restart
obinutuzumab
I'd like to understand what types of infections people have experienced during low neutrophil count. Thanks for any examples. I'm able to stay home for protection against Covid, but I do go out occasionally to a store or a doctor, using precautions.
Before I restart
obinutuzumab
I'd like to understand what types of infections people have experienced during low neutrophil count. Thanks for any examples. I'm able to stay home for protection against Covid, but I do go out occasionally to a store or a doctor, using precautions.
PhotonPal
in
CLL Support
4 years ago
What causes neutrophils to go so low after Obinutuzumab?
Thanks for any thoughts about most likely causes of neutrophils being deeply depleted by
Obinutuzumab
. Paul
Thanks for any thoughts about most likely causes of neutrophils being deeply depleted by
Obinutuzumab
. Paul
PhotonPal
in
CLL Support
4 years ago
Treatment time, hard choice!
The treatments I am deciding between are: Venetoclax/
Obinutuzumab
combo - 12 month. Bendamustine/Rituximab and Venetoclax/Rituximab 16 month trial. Both treatment options begin with a hospital stay. A little afraid of Covid but hospital numbers are down. And she will closely monitor me for TLS.
The treatments I am deciding between are: Venetoclax/
Obinutuzumab
combo - 12 month. Bendamustine/Rituximab and Venetoclax/Rituximab 16 month trial. Both treatment options begin with a hospital stay. A little afraid of Covid but hospital numbers are down. And she will closely monitor me for TLS.
NaturalWaze
in
CLL Support
4 years ago
CLL/SLL Roundtable: Updates on Patient Management (including low dose radiation treatment for early stage SLL)
when compared with
obinutuzumab
plus chlorambucil.
when compared with
obinutuzumab
plus chlorambucil.
AussieNeil
Partner
in
CLL Support
4 years ago
CLL Society Dr. Koffman's ASCO 2020 "Top 12" Picks #s 12, 11, 10
utm_source=June+30%2C+2020&utm_campaign=June+30%2C+2020+Alert&utm_medium=email #10 Initial results of MRD-driven, time-limited therapy with zanubrutinib,
obinutuzumab
and venetoclax https://cllsociety.org/2020/06/asco-2020-top-12-10-initial-results-of-a-multicenter-investigator-initiated-study-of-mrd-driven-time-limited-therapy-with-zanubrutinib-
obinutuzumab
-and-venetoclax
utm_source=June+30%2C+2020&utm_campaign=June+30%2C+2020+Alert&utm_medium=email #10 Initial results of MRD-driven, time-limited therapy with zanubrutinib,
obinutuzumab
and venetoclax https://cllsociety.org/2020/06/asco-2020-top-12-10-initial-results-of-a-multicenter-investigator-initiated-study-of-mrd-driven-time-limited-therapy-with-zanubrutinib-
obinutuzumab
-and-venetoclax
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
Monitoring the basics
This was
Obinutuzumab
+ Chlorambucil for 6 months. Unfortunately, the treatment was aborted after 5 months due to the Covid-19 pandemic.
This was
Obinutuzumab
+ Chlorambucil for 6 months. Unfortunately, the treatment was aborted after 5 months due to the Covid-19 pandemic.
Ageon
in
CLL Support
4 years ago
Triplet Regimen Shows Promise in CLL -Zanubrutinib, obinutuzumab, & venetoclax combo achieves rapid undetectable MRD -MedPageToday -07/07/20
From the article: [i]At the American Society of Clinical Oncology virtual meeting, initial findings from a phase II study were reported on minimum residual disease (MRD)-driven, time-limited therapy with a regimen known as BOVen (zanubrutinib,
obinutuzumab
, and venetoclax) in previously untreated patients
From the article: [i]At the American Society of Clinical Oncology virtual meeting, initial findings from a phase II study were reported on minimum residual disease (MRD)-driven, time-limited therapy with a regimen known as BOVen (zanubrutinib,
obinutuzumab
, and venetoclax) in previously untreated patients
cujoe
in
CLL Support
4 years ago
1
...
10
11
12
...
18
Next page
10
Filter results
Clear filters
Posted in
All communities
CLL Support
337 results
CLL America Support
5 results
Leukaemia Support
4 results
View top 10 communities
Sort by
Most Relevant
Newest