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Summary of 2018 American Society of Clinical Oncologist's Annual Meeting- Prostate Cancer starts at 35:00
PARP Inhibitors (
Lynparza
, Rubraca, Zejula) combined with abiraterone This last topic is what I will address with my oncologist this Friday. Most of this is not FDA approved.
PARP Inhibitors (
Lynparza
, Rubraca, Zejula) combined with abiraterone This last topic is what I will address with my oncologist this Friday. Most of this is not FDA approved.
tallguy2
in
Advanced Prostate Cancer
6 years ago
Plan of attack after Chemo
There is a clinical trial running
LYNPARZA
(Olaparib). They can take a biopsy during and after the trial of that painful rib. I dont have to have the genetic match for optimal effectiveness of Olaparib, but to my surprise, Olaparib will be given in this trial even if there is not a genetic match.
There is a clinical trial running
LYNPARZA
(Olaparib). They can take a biopsy during and after the trial of that painful rib. I dont have to have the genetic match for optimal effectiveness of Olaparib, but to my surprise, Olaparib will be given in this trial even if there is not a genetic match.
abmicro
in
Advanced Prostate Cancer
6 years ago
How lynparza capsules inside medicine look like is it is a Powder or a white gel like substance
Lynparza
capsules ca125
Lynparza
capsules ca125
hassanishtiaq
in
SHARE Ovarian Cancer Support
6 years ago
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Anybody try Keytruda for APC
Chemo, Zytiga, Xtandi, luprin,
Lynparza
. All with no benefits. Looking at my last biopsy I will be trying to get in a trial for Keytruda. Has anybody had any experience with this drug for prostate cancer.
Chemo, Zytiga, Xtandi, luprin,
Lynparza
. All with no benefits. Looking at my last biopsy I will be trying to get in a trial for Keytruda. Has anybody had any experience with this drug for prostate cancer.
Ssullivan19706
in
Advanced Prostate Cancer
6 years ago
I am new here
I am having a really difficult time with the
Lynparza
. The oncologist tells me that it has the fewest side effects of the PARP inhibitors and asked that I give it another month to see if I adjust. Anyone else with difficulties taking
Lynparza
?
I am having a really difficult time with the
Lynparza
. The oncologist tells me that it has the fewest side effects of the PARP inhibitors and asked that I give it another month to see if I adjust. Anyone else with difficulties taking
Lynparza
?
MaryRay
in
SHARE Ovarian Cancer Support
6 years ago
Advanced PCa options. Prescribing doctor disagrees with Specialist
Lam was excited by the very BRACA mutation and recommended
Lynparza
. My dad‘s regular MSO thinks this is ridiculous suggestion and refuses to prescribe it. Again I am racing the clock and feel completely stuck.
Lam was excited by the very BRACA mutation and recommended
Lynparza
. My dad‘s regular MSO thinks this is ridiculous suggestion and refuses to prescribe it. Again I am racing the clock and feel completely stuck.
Damusolf
in
Advanced Prostate Cancer
6 years ago
Lynparza(Olaparib) just doesn't work at all?
Hi everyone, My mom is BRCA active, and has been on Olaparib on maitenance for 48 days as of today. Her CA125 just keeps rising, from 67.17 (day 0)to 751.6 (day 34). So this means the olaparib is just not working for her at all? Has this been the case for someone else? I always thought the Olaparib
Hi everyone, My mom is BRCA active, and has been on Olaparib on maitenance for 48 days as of today. Her CA125 just keeps rising, from 67.17 (day 0)to 751.6 (day 34). So this means the olaparib is just not working for her at all? Has this been the case for someone else? I always thought the Olaparib
dandaping
in
My Ovacome
6 years ago
Parp inhibitor
I have had 12 rounds of chemo and just started this week on
lynparza
. My ca125 numbers dropped from 607 to 110 after chemo. I plan to discuss more detail with my doctor soon, but does this pill stop progress of growth of cells left, or will it kill them off? And I am brca1. Thank you
I have had 12 rounds of chemo and just started this week on
lynparza
. My ca125 numbers dropped from 607 to 110 after chemo. I plan to discuss more detail with my doctor soon, but does this pill stop progress of growth of cells left, or will it kill them off? And I am brca1. Thank you
Myrobynsnest
in
My Ovacome
6 years ago
Starting Lynparza
My sister is waiting for approval to start Olaparib (
lynparza
) after her last round of chemo stopped working for her metatastic breast cancer. Any advice on what to expect? The cancer has spread to her spine amd liver. She is experiencing some pain. Thank you.
My sister is waiting for approval to start Olaparib (
lynparza
) after her last round of chemo stopped working for her metatastic breast cancer. Any advice on what to expect? The cancer has spread to her spine amd liver. She is experiencing some pain. Thank you.
Barbarafh
in
My Breast Cancer Community
7 years ago
Olaparib/Durvalumab Combo Shows Promise in mCRPC
Olaparib/Durvalumab Combo Shows Promise in mCRPC http://www.onclive.com/conference-coverage/gu-2018/olaparibdurvalumab-combo-shows-promise-in-mcrpc Wayne Kuznar Published: Friday, Feb 09, 2018 The PARP inhibitor olaparib (
Lynparza
) appeared to complement the antitumor activity of the PD-L1 inhibitor
Olaparib/Durvalumab Combo Shows Promise in mCRPC http://www.onclive.com/conference-coverage/gu-2018/olaparibdurvalumab-combo-shows-promise-in-mcrpc Wayne Kuznar Published: Friday, Feb 09, 2018 The PARP inhibitor olaparib (
Lynparza
) appeared to complement the antitumor activity of the PD-L1 inhibitor
JLS1
in
Advanced Prostate Cancer
6 years ago
Lynparza
Am starting
Lynparza
next week. Any one else taking it?
Am starting
Lynparza
next week. Any one else taking it?
Lombardi24
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
Olaparib [
Lynparza
] has had success in men with hereditary BRCA1 or BRCA2 mutations. As wonderful as newer drugs such as Zytiga are, resistance can lead to the emergence of cells that are very difficult to manage.
Olaparib [
Lynparza
] has had success in men with hereditary BRCA1 or BRCA2 mutations. As wonderful as newer drugs such as Zytiga are, resistance can lead to the emergence of cells that are very difficult to manage.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Lynparsa
My new treatment for prostate cancer will be provenge and
lynparza
. Got a call from Express Scripts that they don't cover
lynparza
for prostate cancer. Will talk to my oncologist on Monday to appeal this decision. Has anyone had this problem?
My new treatment for prostate cancer will be provenge and
lynparza
. Got a call from Express Scripts that they don't cover
lynparza
for prostate cancer. Will talk to my oncologist on Monday to appeal this decision. Has anyone had this problem?
hysir
in
Advanced Prostate Cancer
7 years ago
Update - CT scan today, continuing Olaparib and 30 days in, of cannabis oil!
My current status (Jan 2017) is that the Olaparib/
Lynparza
is likely not working for me. My count & symptoms have continued to increase. Next step is likely Chemo in March I think... well that’s the oncologists plan anyway.
My current status (Jan 2017) is that the Olaparib/
Lynparza
is likely not working for me. My count & symptoms have continued to increase. Next step is likely Chemo in March I think... well that’s the oncologists plan anyway.
SarahsJourney
in
My Ovacome
7 years ago
Lynparza
Anyone out there on
lynparza
?
Anyone out there on
lynparza
?
Izmeg
in
My Ovacome
7 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
In a phase II study of olaparib (
Lynparza
), a PARP inhibitor, treating patients with metastatic CRPC and DNA repair defects, the drug was proven to lead to high response rates in this patient population.
In a phase II study of olaparib (
Lynparza
), a PARP inhibitor, treating patients with metastatic CRPC and DNA repair defects, the drug was proven to lead to high response rates in this patient population.
JLS1
in
Advanced Prostate Cancer
7 years ago
Olaparib/ lynparza insurance coverage
My doctor has prescribed Olaparib, and pills, and i’m shocked to learn that my copay under Medicare is > $2,240 for 120 pills. Are any of you taking this drug, recently approved for Non BRACA gene ovarian patients? If so, what is Your copay And under what insurance plan? Also , what is your experience
My doctor has prescribed Olaparib, and pills, and i’m shocked to learn that my copay under Medicare is > $2,240 for 120 pills. Are any of you taking this drug, recently approved for Non BRACA gene ovarian patients? If so, what is Your copay And under what insurance plan? Also , what is your experience
CJCM123
in
SHARE Ovarian Cancer Support
7 years ago
Post second line chemo check up - positive news
I have to decide whether I want to have my original tumour tested for the BRCA gene (it's not in my blood) which costs A$1200 - if I am positive it opens up the option of oliaparib (
lynparza
) as a maintenance therapy.
I have to decide whether I want to have my original tumour tested for the BRCA gene (it's not in my blood) which costs A$1200 - if I am positive it opens up the option of oliaparib (
lynparza
) as a maintenance therapy.
Hidden
in
My Ovacome
7 years ago
Lynparza (olaparib), a PARP inhibitor, before CRPC.
The idea seems to be that PARP, a defect repair mechanism, is increasingly called upon during ADT, so there might be synergy between ADT & a PARP inhibitor such as
Lynparza
, well before CRPC emerges. More cell death up-front & a longer mean time to CRPC?
The idea seems to be that PARP, a defect repair mechanism, is increasingly called upon during ADT, so there might be synergy between ADT & a PARP inhibitor such as
Lynparza
, well before CRPC emerges. More cell death up-front & a longer mean time to CRPC?
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Interesting CA125 readings
I am on daily
Lynparza
8 pills Twice a day and Avastin every three weeks since December. My CA125 at the start of this protocol was 150 after a 3 or 4 month I was down to 50. Needless to say I was happy.
I am on daily
Lynparza
8 pills Twice a day and Avastin every three weeks since December. My CA125 at the start of this protocol was 150 after a 3 or 4 month I was down to 50. Needless to say I was happy.
Hidden
in
SHARE Ovarian Cancer Support
7 years ago
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