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Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
LYNPARZA
® (olaparib) tablets, for oral use [prescribing information]: AstraZeneca; 2014. 90. RUBRACA® (rucaparib) tablets, for oral use [prescribing information]: Clovis Oncology, Inc.; 2016. 91.
LYNPARZA
® (olaparib) tablets, for oral use [prescribing information]: AstraZeneca; 2014. 90. RUBRACA® (rucaparib) tablets, for oral use [prescribing information]: Clovis Oncology, Inc.; 2016. 91.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Stage 4 Ovarian Cancer Survival Stories
My mother is BRCA2 + and she started taking Olaparib/
Lynparza
after the chemotherapy. Her last CT scan was one week ago - she was clear and her CA125 were 13. She currently feels good and takes care of my little niece.
My mother is BRCA2 + and she started taking Olaparib/
Lynparza
after the chemotherapy. Her last CT scan was one week ago - she was clear and her CA125 were 13. She currently feels good and takes care of my little niece.
Uniquem
in
My Ovacome
4 years ago
Rapid progression of weakness
He is supposed to start
Lynparza
in 4 days. But he is almost bed ridden due to Legs so weak & Tingly. Anybody have similar experience?
He is supposed to start
Lynparza
in 4 days. But he is almost bed ridden due to Legs so weak & Tingly. Anybody have similar experience?
Willis_Rucker
in
Advanced Prostate Cancer
4 years ago
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Anyone here taking Lynparza and/or Zytiga and struggling to pay for it?
Anyone here taking
Lynparza
and/or Zytiga and struggling to pay for it? Please PM me. I have 1 bottle of each that I'd hate to have to just throw away, per the advice of the hospital where it came from - simply because they cannot take it back.
Anyone here taking
Lynparza
and/or Zytiga and struggling to pay for it? Please PM me. I have 1 bottle of each that I'd hate to have to just throw away, per the advice of the hospital where it came from - simply because they cannot take it back.
JLS1
in
Advanced Prostate Cancer
4 years ago
Olaparib (Lynparza) adds 4.4 months to survival among men who have the BRCA mutation
An update of the PROfound trial proved the benefit in radiographic progression-free survival translated into a significant overall survival benefit too. I updated my article: https://www.prostatecancer.news/2019/10/olaparib-slows-progression-in-men-with.html https://www.nejm.org/doi/10.1056/NEJMoa2022485
An update of the PROfound trial proved the benefit in radiographic progression-free survival translated into a significant overall survival benefit too. I updated my article: https://www.prostatecancer.news/2019/10/olaparib-slows-progression-in-men-with.html https://www.nejm.org/doi/10.1056/NEJMoa2022485
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Alvin - update
Thinking that his cancer med,
Lynparza
, was the true cause of his blood level problem, it was stopped on May 13th. He was given several plasma infusions. When that didn’t solve it, he was given two blood transfusions. First transfusion was Sunday, May 17th.
Thinking that his cancer med,
Lynparza
, was the true cause of his blood level problem, it was stopped on May 13th. He was given several plasma infusions. When that didn’t solve it, he was given two blood transfusions. First transfusion was Sunday, May 17th.
Alvin735
in
Advanced Prostate Cancer
4 years ago
Surgery and Prostrate Cancer Sufferers
Taking 300mg of olaparib (
Lynparza
) 2times a day and monthly Firmagon injections. Testosterone less than 10L. Need shoulder replacement and concerned about healing due to low T and any other possible problems. Anyone have experience or knowledge about surgery for prostrate cancer sufferers.
Taking 300mg of olaparib (
Lynparza
) 2times a day and monthly Firmagon injections. Testosterone less than 10L. Need shoulder replacement and concerned about healing due to low T and any other possible problems. Anyone have experience or knowledge about surgery for prostrate cancer sufferers.
shipoo
in
Advanced Prostate Cancer
4 years ago
DART Trial
We have
Lynparza
as our last treatment option. He wants in the trial. I know the toxicity effects others have experienced with this combo in the past and the results were not promising for those with mCRPC. Mike has t-SCNC.
We have
Lynparza
as our last treatment option. He wants in the trial. I know the toxicity effects others have experienced with this combo in the past and the results were not promising for those with mCRPC. Mike has t-SCNC.
Bird8
in
Advanced Prostate Cancer
4 years ago
Lynparza (olaparib )approved for mCRPC
The FDA has approved olaparib (
Lynparza
) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide
The FDA has approved olaparib (
Lynparza
) for the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
LYNPARZA
Can you speak about any new updates re:
Lynparza
? Thanks.
Can you speak about any new updates re:
Lynparza
? Thanks.
9667
in
SHARE Ovarian Cancer Support
4 years ago
Seeking Updates on Lynparza
I am interested in acquiring any of the latest news/updates on
Lynparza
and OC. Thanks
I am interested in acquiring any of the latest news/updates on
Lynparza
and OC. Thanks
9667
in
SHARE Ovarian Cancer Support
4 years ago
Lynparza [Olaparib] news
Lynparza
Lynparza
(olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair, such as mutations in BRCA1 and/or BRCA2.
Lynparza
Lynparza
(olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumours harbouring a deficiency in homologous recombination repair, such as mutations in BRCA1 and/or BRCA2.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
In focus: targeted therapies - PARP inhibitors
Their availability is different depending on where in the UK you live, so we’ve summarised it below: Olaparib (‘
Lynparza
’) •First and second line through the Cancer Drugs Fund in England and its Welsh and Northern Irish equivalents for BRCA-positive people who meet the criteria.
Their availability is different depending on where in the UK you live, so we’ve summarised it below: Olaparib (‘
Lynparza
’) •First and second line through the Cancer Drugs Fund in England and its Welsh and Northern Irish equivalents for BRCA-positive people who meet the criteria.
OvacomeSupport
Administrator
in
My Ovacome
4 years ago
After two years, My trial has now stopped working
The clinical trial combo of olaparib(
lynparza
) and cediranib that I've been on for nearly two years has stopped working for me. My PSA is escalating along with more lesions and nodules that are more prevalent from my previous scans.
The clinical trial combo of olaparib(
lynparza
) and cediranib that I've been on for nearly two years has stopped working for me. My PSA is escalating along with more lesions and nodules that are more prevalent from my previous scans.
RalphieJr64
in
Advanced Prostate Cancer
4 years ago
Update - now surgery
PSA is still under 10, so staying on
Lynparza
for the time being. Trying to play "whack a mole" .... as the "mole" has been wacking me for the last several months!
PSA is still under 10, so staying on
Lynparza
for the time being. Trying to play "whack a mole" .... as the "mole" has been wacking me for the last several months!
Alvin735
in
Advanced Prostate Cancer
4 years ago
Dr. Oliver Sartor on Rucaparib & Olaparib.
He refers to two FDA PARP inhibitor approvals for PCa, from May 2020. [2]
Olaparib [
] Wikipedia [2a]. FDA notice [2b]. Darryl reported this in May [2c] - received no response. Approval based on the
PROfound
trial. NEJM paper (April) - Johann de Bono.
He refers to two FDA PARP inhibitor approvals for PCa, from May 2020. [2]
Olaparib [
] Wikipedia [2a]. FDA notice [2b]. Darryl reported this in May [2c] - received no response. Approval based on the
PROfound
trial. NEJM paper (April) - Johann de Bono.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Small Cell Neuroendocrine PC Update
It would be to toxic for him to combine the chemo with the
lynparza
at the same time. Mike is on the radar for clinical trials here in our area through the Cleveland Clinic and University Hospitals as well as Dana Farber. In conversation with Dr.
It would be to toxic for him to combine the chemo with the
lynparza
at the same time. Mike is on the radar for clinical trials here in our area through the Cleveland Clinic and University Hospitals as well as Dana Farber. In conversation with Dr.
Bird8
in
Advanced Prostate Cancer
4 years ago
Lynparza
DR is talking about placing me on
Lynparza
. would like to hear story of similar patients who have, or are using,
lynparza
and their experience with it, good or bad. thanks
DR is talking about placing me on
Lynparza
. would like to hear story of similar patients who have, or are using,
lynparza
and their experience with it, good or bad. thanks
akossgolden
in
SHARE Ovarian Cancer Support
4 years ago
LOW BLOOD PRESSURE/ OLAPARIB
HI- HAS ANYONE HAD A PROBLEM WITH EXTREMELY LOW BLOOD PRESSURE WHILE ON
LYNPARZA
(OLAPARIB)? THANKS, LEE
HI- HAS ANYONE HAD A PROBLEM WITH EXTREMELY LOW BLOOD PRESSURE WHILE ON
LYNPARZA
(OLAPARIB)? THANKS, LEE
mupash
in
My Ovacome
4 years ago
"How to Starve Cancer" and Care Oncology Center
I have finished 6 rounds of chemo for stage IIIc ovarian cancer and am slated to receive Avastin/Oliparib (
Lynparza
) for the next two years while being scanned periodically. Seems like my cancer was aggressive enough that my onc doesn't wan't me out of his sight for a while. Sigh.
I have finished 6 rounds of chemo for stage IIIc ovarian cancer and am slated to receive Avastin/Oliparib (
Lynparza
) for the next two years while being scanned periodically. Seems like my cancer was aggressive enough that my onc doesn't wan't me out of his sight for a while. Sigh.
FlowerRose
in
My Ovacome
4 years ago
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