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My dad has CLL with TP53 mutation
As i am writing this im very frightened And i need someone with similar condition My dad was diagnosed back in 2019 With CLL he did about 3 sessions of chemotherapy and went back to remission Lately in January he noticed some lymph nodes in his neck as well as in his face After examination
As i am writing this im very frightened And i need someone with similar condition My dad was diagnosed back in 2019 With CLL he did about 3 sessions of chemotherapy and went back to remission Lately in January he noticed some lymph nodes in his neck as well as in his face After examination
Ornate2001
in
Leukaemia CARE
21 days ago
Ivermectin may help with cancer treatments
Studies of various chronic myeloid leukemia cell lines show that ivermectin kills these lines by inducing mitochondrial dysfunction and the production of free radicals. In mice with leukemia, ivermectin increases the influx of chloride ions in the cells, promoting cell death. When ivermectin is combined
Studies of various chronic myeloid leukemia cell lines show that ivermectin kills these lines by inducing mitochondrial dysfunction and the production of free radicals. In mice with leukemia, ivermectin increases the influx of chloride ions in the cells, promoting cell death. When ivermectin is combined
craterlake
in
CLL Support
21 days ago
2nd generation Jak-i's, what's up?
I posted last year on a 2nd gen Jak inhibitor. This is different from the various recently approved ones for MF (Vonjo etc) that are more related to Gen 1 Jak-i's. The concept is Gen 2 catches Jak2 while it's sleeping while Gen 1s are limited to acting on the awake (active) config of Jak2. This was
I posted last year on a 2nd gen Jak inhibitor. This is different from the various recently approved ones for MF (Vonjo etc) that are more related to Gen 1 Jak-i's. The concept is Gen 2 catches Jak2 while it's sleeping while Gen 1s are limited to acting on the awake (active) config of Jak2. This was
EPguy
in
MPN Voice
22 days ago
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Itching!
If anyone can please help? I've had aquagenic pruritis badly in the past but the wonder drug ruxulitinib stopped it completely. Such a relief. That was 5 yrs ago and it has returned with a vengeance. My hydroxycarbamide was stopped in February ( after 11 years use) even if I brush my skin now the itch
If anyone can please help? I've had aquagenic pruritis badly in the past but the wonder drug ruxulitinib stopped it completely. Such a relief. That was 5 yrs ago and it has returned with a vengeance. My hydroxycarbamide was stopped in February ( after 11 years use) even if I brush my skin now the itch
soomoo
in
MPN Voice
1 month ago
Momelotinib for Myelofibrosis
Hi, I have been suffering from primary MF for 9 years and have been on Ruxolitinib. However recently I was advised that Ruxolitinib is no longer effectively managing my MF. My platelets and Hb are low and my spleen has enlarged again. My consultant is trying to get me approved for Momelotinib. She
Hi, I have been suffering from primary MF for 9 years and have been on Ruxolitinib. However recently I was advised that Ruxolitinib is no longer effectively managing my MF. My platelets and Hb are low and my spleen has enlarged again. My consultant is trying to get me approved for Momelotinib. She
Cazbolac
in
MPN Voice
1 month ago
AXSL1 gene mutation
Hello Everyone, I have pmf-MF with JAK2 mutation and have been taking Rux since the end of 2018. Currently, Rux is took in combination with interferon. From the biopsy and blood routine, I have now reversed to PV (Hemoglobin has significantly improved, and the size of spleen has also shrunk a lot, although
Hello Everyone, I have pmf-MF with JAK2 mutation and have been taking Rux since the end of 2018. Currently, Rux is took in combination with interferon. From the biopsy and blood routine, I have now reversed to PV (Hemoglobin has significantly improved, and the size of spleen has also shrunk a lot, although
merlisa
in
MPN Voice
1 month ago
Still on hold for stem cell transplant
David has now completed 3 cycles of Vidaza. He had a bone marrow biopsy several weeks ago. At first we thought the results were good, that his cancer cells had been reduced sufficiently to proceed with transplant. After our local oncologist spoke to the transplant specialist at Mayo, we received word
David has now completed 3 cycles of Vidaza. He had a bone marrow biopsy several weeks ago. At first we thought the results were good, that his cancer cells had been reduced sufficiently to proceed with transplant. After our local oncologist spoke to the transplant specialist at Mayo, we received word
dwolden
in
CLL Support
2 months ago
Besremi and Rux Combined
I was diagnosed with PV in 2021 and on Hydroxy for about a year. Then in December 2022 was switched to Besremi. I've been on Bes for a little over a year and gradually increased dosage to current 300 mcg. My platelets and HCT kept rising until my last blood work when finally the platelets and HCT
I was diagnosed with PV in 2021 and on Hydroxy for about a year. Then in December 2022 was switched to Besremi. I've been on Bes for a little over a year and gradually increased dosage to current 300 mcg. My platelets and HCT kept rising until my last blood work when finally the platelets and HCT
C_Anne_Orange
in
MPN Voice
2 months ago
Itching in Myelofibrosis
I'm currently taking Fedratinib and Danazol and am having 6 weekly blood transfusions. In the last few months I've noticed increased itching. Last night I woke at 2.30am and the itching made it impossible for me to lie still and go back to sleep. I am on 10mg of Cetirizine Hydrochloride daily and though
I'm currently taking Fedratinib and Danazol and am having 6 weekly blood transfusions. In the last few months I've noticed increased itching. Last night I woke at 2.30am and the itching made it impossible for me to lie still and go back to sleep. I am on 10mg of Cetirizine Hydrochloride daily and though
Bullace
in
MPN Voice
2 months ago
Co pay assistance exhausted for Jakafi
My BCBS coverage through my employer was changed at the new year. Someone decided I was too expensive and changed how drugs were covered. They used to apply toward my deductible and then covered 100%. At the beginning of this year that changed. Drugs no longer factor into the deductible and I have a
My BCBS coverage through my employer was changed at the new year. Someone decided I was too expensive and changed how drugs were covered. They used to apply toward my deductible and then covered 100%. At the beginning of this year that changed. Drugs no longer factor into the deductible and I have a
Wewo01
in
MPN Voice
2 months ago
The prognostic impact of non-driver gene mutations and variant allele frequency in primary myelofibrosis.
The prognostic impact of non-driver gene mutations and variant allele frequency in primary myelofibrosis. To the Editor: Myelofibrosis is a Philadelphia-negative chronic myelo-proliferative-neoplasm (MPN) characterized by alteration of the JAK–STAT path-way, primarily through activating mutations in
The prognostic impact of non-driver gene mutations and variant allele frequency in primary myelofibrosis. To the Editor: Myelofibrosis is a Philadelphia-negative chronic myelo-proliferative-neoplasm (MPN) characterized by alteration of the JAK–STAT path-way, primarily through activating mutations in
PhysAssist
in
MPN Voice
2 months ago
Just wanted to share my Primary Myelofibrosis journey so far…….
Hi all, My diagnosis is Primary Myelofibrosis +Jak-2 &V617F mutation which was in August 2022. This was found after several visits to GP for chest infections and ultrasound scans which found an enlarged spleen. Also had bloods and bone marrow biopsy sent to Bart’s hospital for confirmation. Initial
Hi all, My diagnosis is Primary Myelofibrosis +Jak-2 &V617F mutation which was in August 2022. This was found after several visits to GP for chest infections and ultrasound scans which found an enlarged spleen. Also had bloods and bone marrow biopsy sent to Bart’s hospital for confirmation. Initial
LFCLove
in
MPN Voice
2 months ago
Scientists devise novel strategy to seek and destroy leukemia stem cells
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
PhysAssist
in
MPN Voice
2 months ago
BESREMi now recommended as a Preferred First-line Cytoreductive Therapy for PV in Updated NCCN Clinical Practice Guidelines in Oncology
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
Manouche
in
MPN Voice
2 months ago
HU and Osteoblasts
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
nightshadow
in
MPN Voice
2 months ago
Best treatment for Post PV/MF ?
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
MCW22
in
MPN Voice
2 months ago
Anyone with CLL and Myelodysplasia
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Priss69
in
CLL Support
2 months ago
Transplant Route
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Cazbolac
in
MPN Voice
3 months ago
JAK2 Allele Frequency/Burden
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
FlannelPJs
in
MPN Voice
3 months ago
GVHD and skin dryness.
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Kraskie1915
in
CLL Support
4 months ago
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