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Scientists devise novel strategy to seek and destroy leukemia stem cells
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
PhysAssist
in
MPN Voice
5 months ago
BESREMi now recommended as a Preferred First-line Cytoreductive Therapy for PV in Updated NCCN Clinical Practice Guidelines in Oncology
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
Manouche
in
MPN Voice
5 months ago
HU and Osteoblasts
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
nightshadow
in
MPN Voice
5 months ago
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Best treatment for Post PV/MF ?
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
MCW22
in
MPN Voice
5 months ago
Anyone with CLL and Myelodysplasia
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Priss69
in
CLL Support
5 months ago
Transplant Route
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Cazbolac
in
MPN Voice
5 months ago
Venetoclax has been added to the Pharmaceutical Benefits Scheme in Australia for use as a retreatment for CLL/SLL
The PBS Listing states: [i]"Chronic lymphocytic
leukaemia
(CLL)[/i] [i]Treatment Phase: Dose titration occurring at the start of treatment for relapsed/refractory disease[/i] [i]Clinical criteria:[/i] [i]The condition must have relapsed or be refractory to at least one prior therapy,[/i] [i]AND[
The PBS Listing states: [i]"Chronic lymphocytic
leukaemia
(CLL)[/i] [i]Treatment Phase: Dose titration occurring at the start of treatment for relapsed/refractory disease[/i] [i]Clinical criteria:[/i] [i]The condition must have relapsed or be refractory to at least one prior therapy,[/i] [i]AND[
CLLerinOz
Administrator
in
CLL Support
11 months ago
JAK2 Allele Frequency/Burden
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
FlannelPJs
in
MPN Voice
6 months ago
GP neglect
Her diagnosis CMML a blood disorder linked to
leukaemia
. They have still caught it early but it could have been a very different outcome. So if you are not happy with your test results or you are having symptoms of anything keep pushing your GP.
Her diagnosis CMML a blood disorder linked to
leukaemia
. They have still caught it early but it could have been a very different outcome. So if you are not happy with your test results or you are having symptoms of anything keep pushing your GP.
Shenow
in
Thyroid UK
5 months ago
GVHD and skin dryness.
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Kraskie1915
in
CLL Support
6 months ago
PV and AMD?
I've had PV since 2015 and have been on Jakafi for 18 months. I've recently been diagnosed with age-related macular degeneration and have been treated with intravitreous avastin. I've seen some papers suggesting that AMD is more common for people with MPNs. Has anyone else had this experience? Steve
I've had PV since 2015 and have been on Jakafi for 18 months. I've recently been diagnosed with age-related macular degeneration and have been treated with intravitreous avastin. I've seen some papers suggesting that AMD is more common for people with MPNs. Has anyone else had this experience? Steve
sbs_patient
in
MPN Voice
6 months ago
Has anyone had a Jak2 Blood Test for blood disorders?
Its quite scary reading up on it as its mostly about Bone Marrow cancers &
Leukaemia
etc. Has anyone else come across this before. I'm not too concerned as i've had high Platelets for so long.
Its quite scary reading up on it as its mostly about Bone Marrow cancers &
Leukaemia
etc. Has anyone else come across this before. I'm not too concerned as i've had high Platelets for so long.
Otto11
in
NRAS
2 months ago
itchy skin
Hi all, I have this terrible itchy skin,mostly arms and legs,after any contact with water,apart from the swimming pool,strangely,and wondered if anyone could recommend a cream that would help. I take a high dose fexofenadine before water but it doesnt really help.I asked my GP,who prescribed a tube
Hi all, I have this terrible itchy skin,mostly arms and legs,after any contact with water,apart from the swimming pool,strangely,and wondered if anyone could recommend a cream that would help. I take a high dose fexofenadine before water but it doesnt really help.I asked my GP,who prescribed a tube
Nursey30
in
MPN Voice
7 months ago
Ruxolitinib is intolerant, what should I do
I started taking Ruxolitinib at the end of 2018, when I had a huge spleen, MF3, and was 31 years old. I have been taking this medication for 5 years now. Maybe it's because my situation is worse, because I've been feeling like I have PMF since 2012, but I wasn't diagnosed or intervened until 2017 when
I started taking Ruxolitinib at the end of 2018, when I had a huge spleen, MF3, and was 31 years old. I have been taking this medication for 5 years now. Maybe it's because my situation is worse, because I've been feeling like I have PMF since 2012, but I wasn't diagnosed or intervened until 2017 when
merlisa
in
MPN Voice
7 months ago
Tinituus Quite in the morning
I believe my T is stress related having one of my children go through
leukaemia
treatment along with work Ect. I have read that muscle tension and stress can be a big contributor.
I believe my T is stress related having one of my children go through
leukaemia
treatment along with work Ect. I have read that muscle tension and stress can be a big contributor.
Marsh3l
in
Tinnitus UK
3 months ago
Just diagnosed with 4.0 cm aneurysm of ascending aorta and severe calcification
Hi Friends I cannot express how shocked and dismayed I am finding out that I have severe calcification of my aorta and a 4.0 cm aneurysm. I have read that the aneurysm can be monitored yearly with imaging but there is nothing that can be done for the calcification. In the past 3 years, I have had
Hi Friends I cannot express how shocked and dismayed I am finding out that I have severe calcification of my aorta and a 4.0 cm aneurysm. I have read that the aneurysm can be monitored yearly with imaging but there is nothing that can be done for the calcification. In the past 3 years, I have had
Wewo01
in
MPN Voice
7 months ago
New Treatment Guidelines to Chronic Lymphocytic Leukemia (CLL): Latest advances and emerging treatments.
The Leukemia & Lymphoma Society of Canada recently presented this webinar that I thought was well done and would be of interest to members of this group. To watch the recording of the presentation, follow this link: https://zoom.us/rec/share/n-rsSAwoRlbIj2t2a4IQyN4JKBRAkp1thAGueR0MWS6Vt7lgVFGXpglJ-GyzIyda.H_TslN1eLCB_bs-Y
The Leukemia & Lymphoma Society of Canada recently presented this webinar that I thought was well done and would be of interest to members of this group. To watch the recording of the presentation, follow this link: https://zoom.us/rec/share/n-rsSAwoRlbIj2t2a4IQyN4JKBRAkp1thAGueR0MWS6Vt7lgVFGXpglJ-GyzIyda.H_TslN1eLCB_bs-Y
Northland
in
CLL Support
7 months ago
Median PFS for FCR treated CLL patients with IGHV-M was 14.6 years vs 4.2 years for patients with IGHV-UM. V+O and I+R look to be superior
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
AussieNeil
Partner
in
CLL Support
7 days ago
Imetelstat Users?
Hi All, I have Myelofibrosis and have been taking Jakavi for about 3 years, and it has been pretty successful in suppressing my symptoms. Unfortunately my symptoms are slowly returning, my spleen has enlarged to 215mm and a bone marrow biopsy has shown that the fibrosis is now pretty advanced. I
Hi All, I have Myelofibrosis and have been taking Jakavi for about 3 years, and it has been pretty successful in suppressing my symptoms. Unfortunately my symptoms are slowly returning, my spleen has enlarged to 215mm and a bone marrow biopsy has shown that the fibrosis is now pretty advanced. I
TimGS
in
MPN Voice
7 months ago
Not officially diagnosed...in watch and wait
As the title says, I'm in the WW stage. I saw a hematologist 5 years ago about my lymphocytosis and he felt he could not give a definitive diagnosis. In March this year, I had some stomach issues and bloodwork (above). A peripheral blood smear was done. Below are the notes: There is mild leukocytosis
As the title says, I'm in the WW stage. I saw a hematologist 5 years ago about my lymphocytosis and he felt he could not give a definitive diagnosis. In March this year, I had some stomach issues and bloodwork (above). A peripheral blood smear was done. Below are the notes: There is mild leukocytosis
Purplecat1919
in
CLL Support
15 days ago
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