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How long to Castrate Resistance: ADT+/- ARSI
Further discussion on details of EMBARK study on another HU forum bears restating here (IMO). For high risk BCR (and beyond) ADT combined with ARSI (in this case enzalutamide) is clearly superior to either monotherapy. However, development of castrate resistance between ADT + Enza vs. Enz monotherapy
Further discussion on details of EMBARK study on another HU forum bears restating here (IMO). For high risk BCR (and beyond) ADT combined with ARSI (in this case enzalutamide) is clearly superior to either monotherapy. However, development of castrate resistance between ADT + Enza vs. Enz monotherapy
MateoBeach
in
Advanced Prostate Cancer
6 months ago
ADT Holiday Coming To An End
After nearly 2 years of undetectable while on ADT holiday my 10/2 PSA result was 0.1. Today, 10/23 my PSA was .19. Seems like a rapid doubling time. Sent result to my MO. Waiting for a response.
After nearly 2 years of undetectable while on ADT holiday my 10/2 PSA result was 0.1. Today, 10/23 my PSA was .19. Seems like a rapid doubling time. Sent result to my MO. Waiting for a response.
6357axbz
in
Advanced Prostate Cancer
6 months ago
Does anyone know if you did lu177 early on, can you still continue ADT?
Father just had PC diagnosis with bone mets...
Father just had PC diagnosis with bone mets...
2jznt54
in
Advanced Prostate Cancer
6 months ago
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Hello, I’m new👋🏻 (my results)
Hi everyone, hoping for some help please. These results were done by medi checks last May so I’m aware I need to get new set done. TSH 2.79 (range 0.27-4.2) Free T3 4pmol/L (range 3.1-6.8) Free thyroxine 11.6 (range 12-22) I do not feel well this past few weeks, it’s like I crashed, truly exhausted
Hi everyone, hoping for some help please. These results were done by medi checks last May so I’m aware I need to get new set done. TSH 2.79 (range 0.27-4.2) Free T3 4pmol/L (range 3.1-6.8) Free thyroxine 11.6 (range 12-22) I do not feel well this past few weeks, it’s like I crashed, truly exhausted
FoxyTed
in
Thyroid UK
6 months ago
Thyroid test while on HRT
Hi all,Should I be having a thyroid test since being put on hrt? Was doing well originally on hrt gel when i started it in apr/may. not sure if it's my thyroid or menopause causing the increasing fatigue and hair loss over the last few months. Any advice or suggestions appreciated. Ps don't know thyroid
Hi all,Should I be having a thyroid test since being put on hrt? Was doing well originally on hrt gel when i started it in apr/may. not sure if it's my thyroid or menopause causing the increasing fatigue and hair loss over the last few months. Any advice or suggestions appreciated. Ps don't know thyroid
LawsTra
in
Thyroid UK
6 months ago
Update
Just got my blood test results: Testo less 0.1 ng/ML and PSA still undetectable. Tomorrow I’ll receive my next 3-month Lupron shot, which will finalize my 24-month ADT after prostate bed and whole pelvic radiation. In the meantime I also had lymphoma and received four R-CHOP chemo cycles, two cycles
Just got my blood test results: Testo less 0.1 ng/ML and PSA still undetectable. Tomorrow I’ll receive my next 3-month Lupron shot, which will finalize my 24-month ADT after prostate bed and whole pelvic radiation. In the meantime I also had lymphoma and received four R-CHOP chemo cycles, two cycles
Nusch
in
Advanced Prostate Cancer
6 months ago
LEUPRORELIN ACETATE
Any information on results or side effects for this ADT
Any information on results or side effects for this ADT
Stevegr
in
Advanced Prostate Cancer
6 months ago
Long time reader / first time poster…
Hello all, Been on here for quite some time reading about other men’s stories but have yet to get in the trenches until now. Not sure why; maybe just reluctance to accept my situation, even though my “situation” has fully accepted me. It’s been a bumpy road. PSA 12.5 at diagnosis 11/2019. Been checking
Hello all, Been on here for quite some time reading about other men’s stories but have yet to get in the trenches until now. Not sure why; maybe just reluctance to accept my situation, even though my “situation” has fully accepted me. It’s been a bumpy road. PSA 12.5 at diagnosis 11/2019. Been checking
MrWonderful4U
in
Advanced Prostate Cancer
6 months ago
RED February Week 2
So I booked another appointment and have now been advised to avoid running as I now have a hamstring strain, had
laser
, acupuncture and massage gun
therapy
yesterday and extra exercises added to the list.
So I booked another appointment and have now been advised to avoid running as I now have a hamstring strain, had
laser
, acupuncture and massage gun
therapy
yesterday and extra exercises added to the list.
Sandie1961
Half Marathon
in
Fun Beyond 10K & Race Support
3 months ago
Help with test results
I am feeling a bit better, not so spaced out, no depression or dizziness. I stopped HRT in July. However, I do still get tired, have weight problems, have a swollen scalloped tongue, high cholesterol, goitre, tinnitus, joint stiffness. I am on 100mg Levothyroxine. I take B complex, B1, selenium
I am feeling a bit better, not so spaced out, no depression or dizziness. I stopped HRT in July. However, I do still get tired, have weight problems, have a swollen scalloped tongue, high cholesterol, goitre, tinnitus, joint stiffness. I am on 100mg Levothyroxine. I take B complex, B1, selenium
sunbee
in
Thyroid UK
6 months ago
UPDATE: Dad's Surgery on Broken Ankle Bone and Resulting PSYCHOSIS. QUESTION: How do you deal with Episodes of Hallucinations & Delusions?
Update- ON OUR FATHER WHO RECENTLY BROKE HIS ANKLE WHILE GARDENING, AND THEN UNDERWENT A SUDDEN, UNPLANNED SURGERY ON THE ANKLE , ONLY TO BE FOLLOWED BY THE ONSET OF PSYCHOSIS ALMOST IMMEDIATELY AFTER: BRIEF HISTORY: My dad is 78yo and was diagnosed with Parkinson's in 2010 but likely has had PD close
Update- ON OUR FATHER WHO RECENTLY BROKE HIS ANKLE WHILE GARDENING, AND THEN UNDERWENT A SUDDEN, UNPLANNED SURGERY ON THE ANKLE , ONLY TO BE FOLLOWED BY THE ONSET OF PSYCHOSIS ALMOST IMMEDIATELY AFTER: BRIEF HISTORY: My dad is 78yo and was diagnosed with Parkinson's in 2010 but likely has had PD close
rsacdoolittle
in
Cure Parkinson's
6 months ago
Poor converters
Can anyone give me some stats on the percentage of patients in the UK needing combined therapy T4/T3? That is, percentage of poor converters? Percentage of faulty genes Di01 and DI02? Am writing a follow-up article to the one published for Central Bylines https://centralbylines.co.uk/big-pharma-the-nhs-thyroid-disease-and-me
Can anyone give me some stats on the percentage of patients in the UK needing combined therapy T4/T3? That is, percentage of poor converters? Percentage of faulty genes Di01 and DI02? Am writing a follow-up article to the one published for Central Bylines https://centralbylines.co.uk/big-pharma-the-nhs-thyroid-disease-and-me
judycopage
in
Thyroid UK
11 months ago
Stopping Lupron
Today I’ve had my next medical check. PSA still undetectable after RT IMRT/VMAT to prostate bed and pelvic floor accompanied by 24 months of Lupron. This was my third regimen after DXed in 11/2017, for more details pls refer to my bio. I will now stop Lupron, let’s see what the future will bring.
Today I’ve had my next medical check. PSA still undetectable after RT IMRT/VMAT to prostate bed and pelvic floor accompanied by 24 months of Lupron. This was my third regimen after DXed in 11/2017, for more details pls refer to my bio. I will now stop Lupron, let’s see what the future will bring.
Nusch
in
Advanced Prostate Cancer
4 months ago
Do low PSA-producing cells still rely on testosterone to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
novatimo
in
Advanced Prostate Cancer
7 months ago
Hip Replacement and RA
Hi Everyone, I am 4 weeks, 3 days post op after a hip replacement. Whilst I'm doing great and getting out for daily walks ect, my non-operative leg is swollen from my knee to the ankle. Both knees are painful and I have difficulty bending them. I expectexpected this from the operated leg, however not
Hi Everyone, I am 4 weeks, 3 days post op after a hip replacement. Whilst I'm doing great and getting out for daily walks ect, my non-operative leg is swollen from my knee to the ankle. Both knees are painful and I have difficulty bending them. I expectexpected this from the operated leg, however not
Angie2212
in
NRAS
9 months ago
Hormone Replacement Therapy (HRT)
I just recently read some interesting studies that suggest HRT could help us PD people with our symptoms? I know for some HRT is controversial. And maybe I am at the point of desperation, but should I just be asking my GP for an HRT patch? Have any of you had any experience with HRT. Is one delivery
I just recently read some interesting studies that suggest HRT could help us PD people with our symptoms? I know for some HRT is controversial. And maybe I am at the point of desperation, but should I just be asking my GP for an HRT patch? Have any of you had any experience with HRT. Is one delivery
PalmSprings
in
Cure Parkinson's
7 months ago
EMBARK Study: ADT vs Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Advanced Prostate Cancer
7 months ago
EMBARK Study: Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Fight Prostate Cancer
7 months ago
Are there any free resources?
I go to therapy and really like my therapist but its expensive. Inpay $240/session so i can only afford one session a month. However, i need more. Are there any free therapy or group therapy available for social anxiety, suicidal thoughts, to talk about difficulty in marriage etc?
I go to therapy and really like my therapist but its expensive. Inpay $240/session so i can only afford one session a month. However, i need more. Are there any free therapy or group therapy available for social anxiety, suicidal thoughts, to talk about difficulty in marriage etc?
AsterixSocialanxiety
in
Anxiety and Depression Support
11 months ago
Rheumatoid, Peri-Menopause, HRT
I am 54 and have had RA for 34 years. I am at the end stage of perimenopause, and close to transitioning to Menopause. The RA feels worse. My joints are so achy even my muscles hurt at times. Anyone suggestions from experienced ladies. Does HRT help? My current medication list is Humira 40 by weekly
I am 54 and have had RA for 34 years. I am at the end stage of perimenopause, and close to transitioning to Menopause. The RA feels worse. My joints are so achy even my muscles hurt at times. Anyone suggestions from experienced ladies. Does HRT help? My current medication list is Humira 40 by weekly
ragurl
in
NRAS
7 months ago
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