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Interferon alfa-2b
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Effective Management of Polycythemia Vera With Ropeginterferon Alfa-2b Treatment
Discussion; The results in our study demonstrate that the new dosing regimen of 250-350-500 µg of ropeginterferon alfa-2b is well-tolerated and highly efficacious in patients suffering from PV. This dosing regimen was associated with a rapid achievement of CHR without the need for phlebotomy or erythrocyte
Discussion; The results in our study demonstrate that the new dosing regimen of 250-350-500 µg of ropeginterferon alfa-2b is well-tolerated and highly efficacious in patients suffering from PV. This dosing regimen was associated with a rapid achievement of CHR without the need for phlebotomy or erythrocyte
Manouche
in
MPN Voice
2 months ago
Individualized Dosing of Ropeginterferon Alfa-2b Ensures Optimal Response in Patients with Low-Risk Polycythemia Vera (PV)
Conclusions: High long-term response rates (80.4% at 24 months; 73.2% at 72 months) were achieved with ropeginterferon alfa-2b treatment in the low-risk PV population when the dose was optimized on an individual basis. No specific baseline characteristics among low-risk PV patients appear to be associated
Conclusions: High long-term response rates (80.4% at 24 months; 73.2% at 72 months) were achieved with ropeginterferon alfa-2b treatment in the low-risk PV population when the dose was optimized on an individual basis. No specific baseline characteristics among low-risk PV patients appear to be associated
Manouche
in
MPN Voice
7 months ago
Event-free survival in patients with polycythemia vera treated with Besremi versus best available treatment
»Normal life expectancy may be achievable in PV based on comparable overall survival in interferon-treated patients and a matched US population (p = 0.3), contrasting with shortened survival (p = 0.03) in non-interferon treated patients at the same academic center [3]. Although overall survival was
»Normal life expectancy may be achievable in PV based on comparable overall survival in interferon-treated patients and a matched US population (p = 0.3), contrasting with shortened survival (p = 0.03) in non-interferon treated patients at the same academic center [3]. Although overall survival was
Manouche
in
MPN Voice
11 months ago
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Interferon with PV JAK2/DNMT3A
I'm waiting to see my latest genetic results of JAK2 ab and also if any changes to DNMT3A. I've been on Interferon (90 and then 135mcg) since beg September last year and I wonder if DNMT3A may be causing interferon resistance. I am curious to see if it's just holding the bloods and mutations where they
I'm waiting to see my latest genetic results of JAK2 ab and also if any changes to DNMT3A. I've been on Interferon (90 and then 135mcg) since beg September last year and I wonder if DNMT3A may be causing interferon resistance. I am curious to see if it's just holding the bloods and mutations where they
Fivecatsandcounting
in
MPN Voice
2 days ago
Advice on blood counts, switch to Besremi
MPN community, If you're willing, I'd very much appreciate your advice on/reactions to the results of my blood counts. As you'll see above, 1) my hematocrit is low at 36.7%, well below the goal of 42%, 2) my white blood count is 4.2, below the goal of 10.0, and 3) and my platelets are at 218, below
MPN community, If you're willing, I'd very much appreciate your advice on/reactions to the results of my blood counts. As you'll see above, 1) my hematocrit is low at 36.7%, well below the goal of 42%, 2) my white blood count is 4.2, below the goal of 10.0, and 3) and my platelets are at 218, below
SouthSideA
in
MPN Voice
4 days ago
injection site-red patches
I changed to Pegasys interferon 5 weeks ago and I seem to be coping with it quite well. I’ve had headaches daily since diagnosed in December 2023, these subsided and for the last 2 weeks I was headache free. However the last few days they have returned. I injected my 5th dose last night and I now have
I changed to Pegasys interferon 5 weeks ago and I seem to be coping with it quite well. I’ve had headaches daily since diagnosed in December 2023, these subsided and for the last 2 weeks I was headache free. However the last few days they have returned. I injected my 5th dose last night and I now have
Greengolfer
in
MPN Voice
4 days ago
Besremi - After Two Years
Hi, all. I've been on Besremi for two years now and wanted to share an update and my experience. It's been a very good experience, so far; and I'm optimistic that Besremi is both controlling my blood counts and modifying disease progression. I'm 62 now. I was diagnosed with PV at age 44 and did nothing
Hi, all. I've been on Besremi for two years now and wanted to share an update and my experience. It's been a very good experience, so far; and I'm optimistic that Besremi is both controlling my blood counts and modifying disease progression. I'm 62 now. I was diagnosed with PV at age 44 and did nothing
GardNerd
in
MPN Voice
5 days ago
Interferon
Hi everyone im on 90mg interferon every second week since Feb this year platelets were 1110 came dwn to 916 quick enough but haven't really moved dwn much since actually they went up again and now they are 876 is this the way for any of ye as it seems fairly slow to me even though my hematologist
Hi everyone im on 90mg interferon every second week since Feb this year platelets were 1110 came dwn to 916 quick enough but haven't really moved dwn much since actually they went up again and now they are 876 is this the way for any of ye as it seems fairly slow to me even though my hematologist
VTAR24
in
MPN Voice
5 days ago
Headaches
I am 48 years old and was diagnosed with ET a year ago cal r mutation I'm doing ok good and bad days I'm on aisprin and interferon 90 mg every second week does any one suffer from really bad headaches mainly over left eye feels very like sinus but docs are telling me it's all part of ET my platelets
I am 48 years old and was diagnosed with ET a year ago cal r mutation I'm doing ok good and bad days I'm on aisprin and interferon 90 mg every second week does any one suffer from really bad headaches mainly over left eye feels very like sinus but docs are telling me it's all part of ET my platelets
VTAR24
in
MPN Voice
6 days ago
Started Interferon
About two weeks ago I put a post on here about my anxiety around changing my treatment plan from Hydroxy to Peg Interferon. I had been sent the vaccine but not given any specific instruction about how to self inject. I appreciated the advice I was given from others who had trodden this path before
About two weeks ago I put a post on here about my anxiety around changing my treatment plan from Hydroxy to Peg Interferon. I had been sent the vaccine but not given any specific instruction about how to self inject. I appreciated the advice I was given from others who had trodden this path before
Reggieroo
in
MPN Voice
12 days ago
A Bright Note & Travelling with Besremi
This is just a bit of a bright note. I just finished a bit of a holiday prior to a 5-day conference in Brussels, Belgium. I had to fly with the Besremi then store it for 6 days once in Brussels. The Besremi stayed in the Yeti cooler bag with 2 ice-gel packs for over 12 hours with no problem. TSA
This is just a bit of a bright note. I just finished a bit of a holiday prior to a 5-day conference in Brussels, Belgium. I had to fly with the Besremi then store it for 6 days once in Brussels. The Besremi stayed in the Yeti cooler bag with 2 ice-gel packs for over 12 hours with no problem. TSA
hunter5582
in
MPN Voice
16 days ago
Minimising reaction at injection site?
Any top tips for managing localised reaction at interferon injection sites please? (raised red circles, about 4cm wide and itchy). Will dig out baggier clothes and inject higher next time but any other tips about how to minimise local reaction? Also - I'm taking 45mcg from a 90mcg syringe. I use half
Any top tips for managing localised reaction at interferon injection sites please? (raised red circles, about 4cm wide and itchy). Will dig out baggier clothes and inject higher next time but any other tips about how to minimise local reaction? Also - I'm taking 45mcg from a 90mcg syringe. I use half
RoundTheWorld
in
MPN Voice
22 days ago
Polycythemia vera: past, present and future
»There has been remarkable progress in the development of novel therapeutic approaches for patients with polycythemia vera (PV). Historically, therapy goals in PV were to mitigate thrombotic risks and control blood counts and symptoms. There is now increased focus on disease modification through progressive
»There has been remarkable progress in the development of novel therapeutic approaches for patients with polycythemia vera (PV). Historically, therapy goals in PV were to mitigate thrombotic risks and control blood counts and symptoms. There is now increased focus on disease modification through progressive
Manouche
in
MPN Voice
22 days ago
Clinical impact of mutated JAK2 allele burden reduction in polycythemia vera and essential thrombocythemia
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
Manouche
in
MPN Voice
28 days ago
should I start interferon?
I’d be grateful for any advice or guidance on starting Interferon for ET CalR mutation. I was diagnosed with ET approximately 12 years ago when I was 57. I took Hydroxycarbamide in increasing doses over an approximate 6 year period when the efficacy of the drug began to wane. I was then prescribed
I’d be grateful for any advice or guidance on starting Interferon for ET CalR mutation. I was diagnosed with ET approximately 12 years ago when I was 57. I took Hydroxycarbamide in increasing doses over an approximate 6 year period when the efficacy of the drug began to wane. I was then prescribed
Reggieroo
in
MPN Voice
29 days ago
What to expect at start of Pegasys?
Hello. A question for those of you with PV on Pegasys Interferon please:- If you had side-effects were they from the first injection or did they emerge later? I know this will be dose / individual dependent (I don't yet know dose or frequency). Trying to work out when best to start with family commitments
Hello. A question for those of you with PV on Pegasys Interferon please:- If you had side-effects were they from the first injection or did they emerge later? I know this will be dose / individual dependent (I don't yet know dose or frequency). Trying to work out when best to start with family commitments
RoundTheWorld
in
MPN Voice
1 month ago
Keeping Pegasys injections cool and monitoring temp
Hi, I have recently been diagnosed with Erdheim-Chester Disease after being treated for many years for an MPN, (ET) I have started on Pegasys Interferon and will be travelling by plane soon (yay) and am looking for advice to keep the injections cool. Does anyone use a fridge (or similar) thermometer
Hi, I have recently been diagnosed with Erdheim-Chester Disease after being treated for many years for an MPN, (ET) I have started on Pegasys Interferon and will be travelling by plane soon (yay) and am looking for advice to keep the injections cool. Does anyone use a fridge (or similar) thermometer
LeoTravels
in
MPN Voice
2 months ago
Choosing medication for PV/early MF
Hi Guys, I was diagnosed with PV in January and a BMB showed I have stage 1 Fibrosis on the bone marrow so I have been diagnosed with PV/early MF. My spleen is enlarged but up until very recently my bloods were normal. Now my hematocrit has risen slightly. I had portal and splenic vein thrombosis
Hi Guys, I was diagnosed with PV in January and a BMB showed I have stage 1 Fibrosis on the bone marrow so I have been diagnosed with PV/early MF. My spleen is enlarged but up until very recently my bloods were normal. Now my hematocrit has risen slightly. I had portal and splenic vein thrombosis
DarcyShepp
in
MPN Voice
2 months ago
”low risk” interferon trials
Hi all, just wondering if any folks who have been tagged “low risk” by your care team have tried interferon treatment. I’m a 36 y/o female with PV (60% jak2 mutation), otherwise good health. My MPN specialist discussed the latest trials and research being done on “low risk” patients, stating I could
Hi all, just wondering if any folks who have been tagged “low risk” by your care team have tried interferon treatment. I’m a 36 y/o female with PV (60% jak2 mutation), otherwise good health. My MPN specialist discussed the latest trials and research being done on “low risk” patients, stating I could
TwinMom88
in
MPN Voice
2 months ago
whiplash pain and interferon
hi everyone I started interferon about 6 weeks ago and apart from a bit of nausea and the odd ache the day after seem ( fingers crossed) to be tolerating it ok. However, we’re on Anglesey with friends ( all 70 ish) and thinking we all feel like spring chickens, we decided to book a rib ride under the
hi everyone I started interferon about 6 weeks ago and apart from a bit of nausea and the odd ache the day after seem ( fingers crossed) to be tolerating it ok. However, we’re on Anglesey with friends ( all 70 ish) and thinking we all feel like spring chickens, we decided to book a rib ride under the
Loubprv
Volunteer
in
MPN Voice
2 months ago
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