A case for statin use in ET and PV: Again, not... - MPN Voice

On the first study, It's not clear whether treating high cholesterol is the mechanism for the benefit or the statin has a benefit separate from cholesterol (lipid) status. It seems lipid is the driver from this:

"This novel finding supports consensus MPN clinical guidelines recommendation to address hyperlipidemia as one of the modifiable cardiovascular risk factors in patients with PV and ET"

It brings the question, is there a statin benefit for pts with normal lipids?

Mine was increasing last check but in range. I will ask for another test since I'm on Rux.

monarch500017 days ago

What specific statins?

Loooonglife• in reply tomonarch500017 days ago

I doubt the analysis in this article differentiates by type of statin. The 3 most commonly prescribed statins are Atorvastatin, Simvastatin, and Rosuvastatin.

mazeoffire17 days ago

In my native Germany, cholesterol checks seem to be part of normal check-ups whereas this doesn’t seem to be the case in the UK. I requested cholesterol twice and it was too high, yet the nurse told me to wait and monitor before prescribing statins. Then I had a nerve impingement and/migraine presenting itself as a stroke and the consultant prescribed me statins. As metabolic syndrome runs in my family, I suppose it is just as well. I suppose the less cloggy and sticky stuff iss flowing about your arteries, the better (my platelets are too high). However, very low cholesterol can make you unwell as well. Hopefully, the researchers will dig deeper and find the exact mechanisms of the interactions of statins and ET and PV.

ainslie16 days ago

my experience of discussing this and listening to experts is it seems it’s mainly Dr Hasselbach and a few Danish associates who recommend statins as part of the MPN treatment when there is not a cholesterol issue