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Enzalutamide
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ADT 's effect on body fat and muscle mass from Life on ADT blog by Richard Wassersug
It turns out that adding abiraterone to standard ADT increases the diabetic risk slightly, while adding
enzalutamide
reduces that risk for some men on ADT. This can be partly understood by changes in the androgen receptor, which is targeted by
enzalutamide
.
It turns out that adding abiraterone to standard ADT increases the diabetic risk slightly, while adding
enzalutamide
reduces that risk for some men on ADT. This can be partly understood by changes in the androgen receptor, which is targeted by
enzalutamide
.
Scout4answers
in
Advanced Prostate Cancer
6 months ago
Good news for mCRPC (hopefully), phase 2
And here we go: "mCRPC patients who have relapsed or are refractory to androgen receptor signalling inhibitors (ARSIs) such as apalutamide, darolutamide, abiraterone and
enzalutamide
are included in the study." https://www.clinicaltrialsarena.com/news/oncternal-patient-prostate-cancer/
And here we go: "mCRPC patients who have relapsed or are refractory to androgen receptor signalling inhibitors (ARSIs) such as apalutamide, darolutamide, abiraterone and
enzalutamide
are included in the study." https://www.clinicaltrialsarena.com/news/oncternal-patient-prostate-cancer/
Maxone73
in
Advanced Prostate Cancer
7 months ago
Anyone tried cabazitaxel (Jevtana) monotherapy?
I'm also thinking about taking
enzalutamide
(Xtandi) [u]after[/u] the cabazitaxel if I still have detectable PSA. Thanks in advance.
I'm also thinking about taking
enzalutamide
(Xtandi) [u]after[/u] the cabazitaxel if I still have detectable PSA. Thanks in advance.
ron_bucher
in
Advanced Prostate Cancer
5 months ago
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Enzalutamide any advice/tips for dealing with side effects
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation. What are the main side effects of
Enzalutamide
and does anyone have advice or tips with dealing with side effects of this drug. Any advice would be much appreciated.
Now doctors are suggesting that possible option is to switch onto Xtandi/
Enzalutamide
. Anyone in the same or similar situation. What are the main side effects of
Enzalutamide
and does anyone have advice or tips with dealing with side effects of this drug. Any advice would be much appreciated.
Ronnie7C
in
Advanced Prostate Cancer
7 months ago
enzalutamide dosing
I have ealrly stage 4 prostate cancer, have been on lupron for just over 4 months, and
enzalutamide
Xtandi for just under 4 months. Not enjoying the side effects of 160 mg I reduced my dosage to 80 mg and tolorate it a little better.
I have ealrly stage 4 prostate cancer, have been on lupron for just over 4 months, and
enzalutamide
Xtandi for just under 4 months. Not enjoying the side effects of 160 mg I reduced my dosage to 80 mg and tolorate it a little better.
3step
in
Advanced Prostate Cancer
8 months ago
Dad with Stage 4 PCa - Need some words of wisdom...again please!
Oncologist put Dad on
Enzalutamide
- been on it for 6 cycles - tolerated well but his PSA has gone from 76 to 87 in one week. So
Enzalutamide
has started to become 'ineffective'.
Oncologist put Dad on
Enzalutamide
- been on it for 6 cycles - tolerated well but his PSA has gone from 76 to 87 in one week. So
Enzalutamide
has started to become 'ineffective'.
kikinini
in
Advanced Prostate Cancer
5 months ago
Genitourinary Cancers Symposium Meeting Coverage, MedPage Today, January 2024
Latest 2024 PCa-related GuCS Meeting Coverage from MedPage Today: [i]
More Evidence That ARSIs for Prostate Cancer Differ in Cognitive Effects -More fatigue, depression, worse reaction time with
as compared with abiraterone, January 29, 2024:[/i] https://www.medpagetoday.com/meetingcoverage
Latest 2024 PCa-related GuCS Meeting Coverage from MedPage Today: [i]
More Evidence That ARSIs for Prostate Cancer Differ in Cognitive Effects -More fatigue, depression, worse reaction time with
as compared with abiraterone, January 29, 2024:[/i] https://www.medpagetoday.com/meetingcoverage
cujoe
in
Fight Prostate Cancer
3 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Remember NCCN protocol is to start
enzalutamide
or apalutamide if PSA clearly rising.” Then I was shocked this week to read that SOC has only a 20% success rate! Do any of you more experienced gentlemen have any observations for me? I certainly don’t know whether to be scared or relaxed! Thx
Remember NCCN protocol is to start
enzalutamide
or apalutamide if PSA clearly rising.” Then I was shocked this week to read that SOC has only a 20% success rate! Do any of you more experienced gentlemen have any observations for me? I certainly don’t know whether to be scared or relaxed! Thx
jackwfrench
in
Advanced Prostate Cancer
4 months ago
Hospitalizations Among Veterans Treated for Metastatic Prostate Cancer With Abiraterone or Enzalutamide
This study compares hospitalizations among patients treated initially with abiraterone versus
enzalutamide
. Total rate of hospitalization increased 22% for abiraterone compared to a 3% increase for
enzalutamide
in the 12 months after ARPI initiation (P < .0001).
This study compares hospitalizations among patients treated initially with abiraterone versus
enzalutamide
. Total rate of hospitalization increased 22% for abiraterone compared to a 3% increase for
enzalutamide
in the 12 months after ARPI initiation (P < .0001).
kainasar
in
Advanced Prostate Cancer
9 months ago
Does this mark the beginning of castration resistance?
Since May 2023, dad has been on monthly Degarelix (Firmagon) injections and on a regime of 160 mg of
Enzalutamide
daily (Xtandi). His PSA reached a nadir of 0.02 in March 2024. Most recent PSA in April 2024 showed an PSA increase to 0.03 with testosterone value of 0.41 ng/ml.
Since May 2023, dad has been on monthly Degarelix (Firmagon) injections and on a regime of 160 mg of
Enzalutamide
daily (Xtandi). His PSA reached a nadir of 0.02 in March 2024. Most recent PSA in April 2024 showed an PSA increase to 0.03 with testosterone value of 0.41 ng/ml.
Agh-2022
in
Advanced Prostate Cancer
25 days ago
Olaparib for Metastatic Castration-Resistant Prostate Cancer With BRCA1 and/or BRCA2 Alterations
TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer who have BRCA and/or ATM mutations had improved survival outcomes with olaparib monotherapy compared with abiraterone or
enzalutamide
therapy.
TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer who have BRCA and/or ATM mutations had improved survival outcomes with olaparib monotherapy compared with abiraterone or
enzalutamide
therapy.
Balsam01
in
Advanced Prostate Cancer
5 months ago
Nano enzalutamide: nanocrystalline version of enza is going to be tested
It could improve QoL as it means taking less pills...I don't know, my QoL would feel a lot better with a "hey! you are cured!" but.... results in Q1 of this year https://bnnbreaking.com/breaking-news/health/nanoform-begins-clinical-trial-for-nanocrystalline-version-of-prostate-cancer-drug/
It could improve QoL as it means taking less pills...I don't know, my QoL would feel a lot better with a "hey! you are cured!" but.... results in Q1 of this year https://bnnbreaking.com/breaking-news/health/nanoform-begins-clinical-trial-for-nanocrystalline-version-of-prostate-cancer-drug/
Maxone73
in
Advanced Prostate Cancer
4 months ago
Pinostilbene inhibits the Enz-resistant CRPC cell line by inhibiting AR variant 7
in any event if you are failing on
enzalutamide
or any PCa warrior you probably should take pterostilbene.
in any event if you are failing on
enzalutamide
or any PCa warrior you probably should take pterostilbene.
KocoPr
in
Fight Prostate Cancer
5 months ago
Could I try BAT to restore sensitivity to previously used antiandrogen treatments.
I failed Abiraterone and SOC doesn't allow the switch to
Enzalutamide
. I was reading on the use of BAT to resensitize mCRPC. Would this be a therapy that could work or is it too late now that I have failed. I know its not SOC but I am running out of choices and looking for some clarity.
I failed Abiraterone and SOC doesn't allow the switch to
Enzalutamide
. I was reading on the use of BAT to resensitize mCRPC. Would this be a therapy that could work or is it too late now that I have failed. I know its not SOC but I am running out of choices and looking for some clarity.
Islandboy2021
in
Advanced Prostate Cancer
7 months ago
ADT or not?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
Hi, i have Stage 4 PCA, Gleason 5+4 so I am on Degaralix and
Enzalutamide
. I tend to refer to this treatment as ADT as shorthand because to my mind they both reduce testosterone. I wonder if I’m misusing ADT or does it matter?
FortyWinks
in
Advanced Prostate Cancer
8 months ago
Need help understanding Enzalutamide
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Help us understand what to expect with the SE of
Enzalutamide
. Soapchick
Hidden
in
Advanced Prostate Cancer
8 months ago
How long to Castrate Resistance: ADT+/- ARSI
Another measure is PSA progression which is available for all groups as a proxy for regimen failure: This is 2.3% (8/355) for ADT+E combo; 26% (93/358) for ADT mono; and 10% (37/355) for
Enzalutamide
monotherapy. Paul/MateoBeach
Another measure is PSA progression which is available for all groups as a proxy for regimen failure: This is 2.3% (8/355) for ADT+E combo; 26% (93/358) for ADT mono; and 10% (37/355) for
Enzalutamide
monotherapy. Paul/MateoBeach
MateoBeach
in
Advanced Prostate Cancer
6 months ago
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
Maxone73
in
Fight Prostate Cancer
3 months ago
Post Degaralix
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
I know it’s doing it’s thing, along with
enzalutamide
but feeling my quality of life balance is tipping to far the other way. Hoping I’ll feel differently by the end of today.
FortyWinks
in
Advanced Prostate Cancer
7 months ago
Xtandi and insomnia
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Anybody else have severe insomnia from
enzalutamide
? I'm only getting ~3 hours sleep since starting. Pretty deep fatigue too. Any advice on ways to manage this?
Djangler
in
Advanced Prostate Cancer
9 months ago
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