TALAPRO-2 final data: a win for BRCA+ mCRPC, less positive data for other HRR mutations (like my ATM)

[Maxone73]

Ok, now I would LOVE to see the same trial using the new parp inhibitor saruparib , which is considered waaaaay less toxic and more targeted compared to the others, but…

The TALAPRO-2 trial confirmed that talazoparib + enzalutamide significantly improves overall survival (OS) in HRR-deficient mCRPC, with BRCA1/2-mutated patients seeing the greatest benefit. Their median OS was not reached, compared to 28.5 months with enzalutamide alone. For non-BRCA HRR mutations, the 10-month OS improvement (42.4 vs. 32.6 months) showed a positive trend but was not statistically significant yet (a bigger sample is probably needed). The findings reinforce HRR testing as critical for treatment selection, solidifying PARP inhibition as a key strategy in BRCA1/2-driven mCRPC. The trend looks positive also for the other HRR mutations but further research is needed to confirm it.

prostatewarriors.com/2025/0...

[KocoPr]

this Saruparib trial results interest me on this specific PARP1 inhibitor.

Phase III meaning it is close to be approved.

chatGPT;

• EvoPAR-Prostate01 Trial: A Phase III, double-blind, placebo-controlled study assessing saruparib in combination with physician’s choice of new hormonal agents (NHAs) in men with metastatic castration-sensitive prostate cancer (mCSPC). The trial includes two cohorts based on homologous recombination repair mutation (HRRm) status, aiming to evaluate the efficacy of saruparib plus NHA versus placebo plus NHA

[Maxone73 in reply to KocoPr]

One of the doctor I talked to is the chief of saruparib trial in whole Italy. He disappointed me when he said that the current trial don't include ATM mutations yet, but when I asked if saruparib was performing well he said he could not say anything yet and that I had to interpret his non verbal language. Then he looked at me with a big smile! 😂😂

[KocoPr in reply to Maxone73]

When i used to travel for work in diff countries and didn’t know the language i just always smiled and that always got good vibes back. So the smile IS the international language.