Treatment Holiday

[Sebara]

My MO suggested a months holiday from my Enzalutamide tablets to better my QoL.My PSA is undetectable at 0.008 and has been for 4 years.

Your advice on any foreseeable dangers

[6357axbz]

not sure how much QOL one month will provide. I was undetectable for years as well and on a holiday foe 18 months. When PSA crept up just beyond undetectable I went back on meds and became undetectable again

[Tall_Allen]

IDK if a month is long enough to enjoy a return of testosterone.

[Justfor_]

Dosage adjustment is a smarter control tactic compared to crude ON-OFF. You may check my Bicalutamide maneuvers thread.

[3putt]

I started my first vacation on November 10th after almost 8 years of Zytiga, prednisone and lupron. On the positive side I started feeling like my old self within a few weeks. No fog, no dizziness, and definitely more energetic. On the negative side I have bone and joint pain. On a pain scale of 1 to 10 it’s mostly a 3 with exception of fingers where it’s more like a 5. Not sure what the future holds but so far the QOL is certainly worth the inconvenience of a little pain here and there! Best wishes on your journey.

[Mgtd in reply to 3putt]

Perhaps there is a need to check out other reasons for bone pain inflammation. It could be something simple and not PC related.

Are you currently exercising and doing stretching type activities?

[j-o-h-n]

Ok, as long as you don't vacation in the Sahara, Sebara.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Sebara in reply to j-o-h-n]

I have a Toyota Sahara

[j-o-h-n]

I bet yours is equipped with the 326 camelpower engine.

Good Luck, Good Health and Good Humor.

j-o-h-n

[AlmostnoHope]

Take the holiday. It will insure your continued response to the ENZ and will prolong your life.

[SteveTheJ]

Started Erleada + Lupron April 2020. PSA undetectable after some period. Testosterone went from 400 before therapy to a low of 4 as recently as Jan 2024. On advice of oncologist, because there were no tumors on scans for 3 consecutive years, last dose of Lupron was July 2023.

Sometime in 2024, close to a year after no Lupron, testosterone started going up until it's now about 150. I could start Lupron again anytime based on whatever factors the oncologist determines, albeit currently unmeasurable PSA.