Search
Search
About
Log in
Join
Experiences with
Dihydrotestosterone
Posts
Communities
68 public posts
Filter results
Using Testosterone to Treat Prostate Cancer
Finasteride is a drug that inhibits 5-reductase (5AR) type 2, which is an enzyme that converts T to 5-
dihydrotestosterone
(DHT). In the prostate cell, T is almost always converted to DHT by 5AR type 2 and DHT binds to iAR approximately 5 times more strongly than T does [14].
Finasteride is a drug that inhibits 5-reductase (5AR) type 2, which is an enzyme that converts T to 5-
dihydrotestosterone
(DHT). In the prostate cell, T is almost always converted to DHT by 5AR type 2 and DHT binds to iAR approximately 5 times more strongly than T does [14].
Ralph1966
in
Advanced Prostate Cancer
4 years ago
[EAU-2020] Enzyme inhibition for overcoming CRPC.
“Then, DHEA is further processed into the more biologically active compounds, testosterone and
dihydrotestosterone
.'" "'Significant circulating concentrations of DHEAS still exist in patients with prostate cancer being treated with abiraterone,” Gao continued.
“Then, DHEA is further processed into the more biologically active compounds, testosterone and
dihydrotestosterone
.'" "'Significant circulating concentrations of DHEAS still exist in patients with prostate cancer being treated with abiraterone,” Gao continued.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Insulin and Prostate.
I'd gone as far as I could in researching the condition and came up against 'testosterone and
dihydrotestosterone
' leaving it at that - it's a hormone thing right?
I'd gone as far as I could in researching the condition and came up against 'testosterone and
dihydrotestosterone
' leaving it at that - it's a hormone thing right?
MikePollard
in
Low-Carb High-Fat (LCHF)
4 years ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
Dihydrotestosterone and Long-Term Risk for Prostate Cancer Mortality
https://pubmed.ncbi.nlm.nih.gov/32368817/?from_term=prostate&from_sort=date&from_page=2&from_pos=1&fbclid=IwAR3LvWhaSIZ9XIKz6zOLg9erjAa8d46sEtqgg7AthGf7U4uZDM1xYBcIq1g
https://pubmed.ncbi.nlm.nih.gov/32368817/?from_term=prostate&from_sort=date&from_page=2&from_pos=1&fbclid=IwAR3LvWhaSIZ9XIKz6zOLg9erjAa8d46sEtqgg7AthGf7U4uZDM1xYBcIq1g
kainasar
in
Advanced Prostate Cancer
4 years ago
Association Between Dihydrotestosterone and Long-Term Risk for PCa Mortality
Keywords:
dihydrotestosterone
; prognosis; prostate cancer. © 2020 Wiley Periodicals, Inc.
Keywords:
dihydrotestosterone
; prognosis; prostate cancer. © 2020 Wiley Periodicals, Inc.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
TMPRSS2 & COVID-19
Intratumoral
dihydrotestosterone
(DHT) concentrations were significantly higher in the cancerous tissues compared to benign prostate (P < 0.001).
Intratumoral
dihydrotestosterone
(DHT) concentrations were significantly higher in the cancerous tissues compared to benign prostate (P < 0.001).
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Nuclear Receptor ERRα Contributes to Castration-Resistant Growth of Prostate Cancer via Its Regulation of Intratumoral Androgen Biosynthesis
"ERRα exhibited an increased expression in metastatic CRPC" It "could act to promote castration-resistant growth via direct transactivation of two key androgen synthesis enzymes CYP11A1 and AKR1C3, and hence enhance intraprostatic production of
dihydrotestosterone
(DHT) and activation of AR signaling
"ERRα exhibited an increased expression in metastatic CRPC" It "could act to promote castration-resistant growth via direct transactivation of two key androgen synthesis enzymes CYP11A1 and AKR1C3, and hence enhance intraprostatic production of
dihydrotestosterone
(DHT) and activation of AR signaling
pjoshea13
in
Advanced Prostate Cancer
4 years ago
HSD3B1 Genotype in Metastatic Castration-Sensitive Prostate Cancer
Hampel, MD Importance The adrenal-restrictive HSD3B1(1245A) allele limits extragonadal
dihydrotestosterone
synthesis, whereas the adrenal-permissive HSD3B1(1245C) allele augments extragonadal
dihydrotestosterone
synthesis.
Hampel, MD Importance The adrenal-restrictive HSD3B1(1245A) allele limits extragonadal
dihydrotestosterone
synthesis, whereas the adrenal-permissive HSD3B1(1245C) allele augments extragonadal
dihydrotestosterone
synthesis.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 & 2 by the Androgen Receptor in Prostate Cancer - Endocrinology, April 2017
I'm sure my good friend, npfisherman, will chime in with some relative commentary, but here is the paper's abstract: [i]
Abstract
5α-Reductase types 1 and 2, encoded by SRD5A1 and SRD5A2, are the two enzymes that can catalyze the conversion of testosterone to
dihydrotestosterone
, the most potent
I'm sure my good friend, npfisherman, will chime in with some relative commentary, but here is the paper's abstract: [i]
Abstract
5α-Reductase types 1 and 2, encoded by SRD5A1 and SRD5A2, are the two enzymes that can catalyze the conversion of testosterone to
dihydrotestosterone
, the most potent
cujoe
in
Fight Prostate Cancer
4 years ago
Health Risks Associated With Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm
PMID: 32202088 DOI: 10.5534/wjmh.200012 Abstract 5α-
dihydrotestosterone
(5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands.
PMID: 32202088 DOI: 10.5534/wjmh.200012 Abstract 5α-
dihydrotestosterone
(5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Male pattern balding in women.
https://www.hormone.org › glands-and-hormones-a-to-z DHT, or
dihydrotestosterone
, is an androgen produced as a byproduct of testosterone. ...
https://www.hormone.org › glands-and-hormones-a-to-z DHT, or
dihydrotestosterone
, is an androgen produced as a byproduct of testosterone. ...
Angelic69
in
Thyroid UK
4 years ago
DHT / Avodart
Dr Myers used Avodart in men on ADT who nonetheless produced significant levels of
dihydrotestosterone
[DHT]. (The true target of ADT is DHT - not testosterone [T].) Myers used blood tests to monitor DHT. My concern with DHT is that it might be made within cancer cells.
Dr Myers used Avodart in men on ADT who nonetheless produced significant levels of
dihydrotestosterone
[DHT]. (The true target of ADT is DHT - not testosterone [T].) Myers used blood tests to monitor DHT. My concern with DHT is that it might be made within cancer cells.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Post-RP tTestosterone to DHT ratio
Over 95% of testosterone is converted to the most important prostatic androgen
dihydrotestosterone
." https://link.springer.com/article/10.1007/BF01643679 Edit: Units error correction
Over 95% of testosterone is converted to the most important prostatic androgen
dihydrotestosterone
." https://link.springer.com/article/10.1007/BF01643679 Edit: Units error correction
Hidden
in
Advanced Prostate Cancer
5 years ago
5ARIs & the PCa Masking issue.
They do this by inhibiting the aromatization of testosterone [T] to the more potent
dihydrotestosterone
[DHT]. BPH-related PSA is reduced.
They do this by inhibiting the aromatization of testosterone [T] to the more potent
dihydrotestosterone
[DHT]. BPH-related PSA is reduced.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
BAT stumped, padding up for second innings
Anti inflammatories: curcumin, ginger, green tea, resveratrol, zyflamend, indomethacin. 4. 5 alpha reductase (5AR) inhibitors. 5AR is an enzyme that mediates the conversion of T into the far more potent androgen,
dihydrotestosterone
(DHT).
Anti inflammatories: curcumin, ginger, green tea, resveratrol, zyflamend, indomethacin. 4. 5 alpha reductase (5AR) inhibitors. 5AR is an enzyme that mediates the conversion of T into the far more potent androgen,
dihydrotestosterone
(DHT).
kaptank
in
Advanced Prostate Cancer
5 years ago
Adrenal androgens rescue prostatic dihydrotestosterone production and growth of prostate cancer cells after castration.
DHEA & DHEA-S "are potential substrates for intracrine production of testosterone (T) and
dihydrotestosterone
(DHT), or directly to DHT, by prostate cancer (PCa) cells."
DHEA & DHEA-S "are potential substrates for intracrine production of testosterone (T) and
dihydrotestosterone
(DHT), or directly to DHT, by prostate cancer (PCa) cells."
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Red Hot Peppers
Promoter assays showed that capsaicin inhibited the ability of
dihydrotestosterone
to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct
Promoter assays showed that capsaicin inhibited the ability of
dihydrotestosterone
to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct
George71
in
Advanced Prostate Cancer
5 years ago
Role of Estrogen in Androgen-Induced PCa in NBL Rats.
"Addition of estradiol to 5α-
dihydrotestosterone
treatment did not markedly enhance prostate cancer incidence (14%)" "adding estradiol to testosterone treatment ... induced a 100% tumor incidence."
"Addition of estradiol to 5α-
dihydrotestosterone
treatment did not markedly enhance prostate cancer incidence (14%)" "adding estradiol to testosterone treatment ... induced a 100% tumor incidence."
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Testosterone.
We have seen two PCa prevention trials that sought to protect men by lowering
dihydrotestosterone
[DHT] levels: (1) the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial & (2) the {Finasteride} Prostate Cancer Prevention Trial (PCPT).
We have seen two PCa prevention trials that sought to protect men by lowering
dihydrotestosterone
[DHT] levels: (1) the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial & (2) the {Finasteride} Prostate Cancer Prevention Trial (PCPT).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Thoughts on BAT
I know some readers supplement with finasteride (Proscar) and dutasteride (Avodart), 2 old antiandrogens that inhibit 5-alphareductase (5AR) and prevent the formation of
dihydrotestosterone
(DHT), a very powerful androgen that our cancers love.
I know some readers supplement with finasteride (Proscar) and dutasteride (Avodart), 2 old antiandrogens that inhibit 5-alphareductase (5AR) and prevent the formation of
dihydrotestosterone
(DHT), a very powerful androgen that our cancers love.
kaptank
in
Advanced Prostate Cancer
5 years ago
1
2
3
4
Next page
Filter results
Clear filters
Posted in
All communities
Advanced Prostate Cancer
57 results
Fight Prostate Cancer
4 results
Thyroid UK
3 results
View top 10 communities
Sort by
Most Relevant
Newest