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Dihydrotestosterone
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Foods/Supplements-Vitamins: Cruciferous Phytochemicals - [3] 3,3'-Diindolylmethane [DIM]
Dihydrotestosterone
(DHT) treatment decreased the expression of AR and AR3, and reversed the expression of these EMT and stem cell marker genes.
Dihydrotestosterone
(DHT) treatment decreased the expression of AR and AR3, and reversed the expression of these EMT and stem cell marker genes.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
DHT Testing: Do You Get It? I'm Trying to Convince My Med Onc to Provide It
From what I've read on this site, DHT (
dihydrotestosterone
) testing is more important than T (testosterone) testing. So I asked my Kaiser Permanente med onc for it. He asked what clinical trials establish that there is a survival benefit to DHT testing.
From what I've read on this site, DHT (
dihydrotestosterone
) testing is more important than T (testosterone) testing. So I asked my Kaiser Permanente med onc for it. He asked what clinical trials establish that there is a survival benefit to DHT testing.
Neal-Snyder
in
Advanced Prostate Cancer
7 years ago
Foods/Supplements-Vitamins: Medicinal Fungi - Reishi - Ganoderma lucidum
Furthermore, G. lucidum crude extract and fraction GLF4 interfere with androgen receptor function via competition with the natural ligand
dihydrotestosterone
and suppression of androgen receptor/androgen response element complex formation.
Furthermore, G. lucidum crude extract and fraction GLF4 interfere with androgen receptor function via competition with the natural ligand
dihydrotestosterone
and suppression of androgen receptor/androgen response element complex formation.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
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Foods/Supplements-Vitamins: Neem leaf (from Azadirachta indica)
. - Mayo Clinic) follow-on from [2c], using "supercritical extract of neem leaves (SENL)" "Treatment of LNCaP-luc2 prostate cancer cells with SENL suppressed
dihydrotestosterone
-induced androgen receptor and prostate-specific antigen levels.
. - Mayo Clinic) follow-on from [2c], using "supercritical extract of neem leaves (SENL)" "Treatment of LNCaP-luc2 prostate cancer cells with SENL suppressed
dihydrotestosterone
-induced androgen receptor and prostate-specific antigen levels.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Indomethacin / Xtandi
From the preamble (translation below): "Type 5 17β-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (AKR1C3) converts Δ(4)-androstene-3,17-dione and 5α-androstane-3,17-dione to testosterone (T) and 5α-
dihydrotestosterone
, respectively, in castration resistant prostate cancer (CRPC).
From the preamble (translation below): "Type 5 17β-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (AKR1C3) converts Δ(4)-androstene-3,17-dione and 5α-androstane-3,17-dione to testosterone (T) and 5α-
dihydrotestosterone
, respectively, in castration resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer.
"Average testosterone levels were within normal limits, although
dihydrotestosterone
(DHT) levels on average were supraphysiologic in cohort 3." I wouldn't use T without taking Avodart to limit conversion to DHT (& Arimidex to limit estradiol).
"Average testosterone levels were within normal limits, although
dihydrotestosterone
(DHT) levels on average were supraphysiologic in cohort 3." I wouldn't use T without taking Avodart to limit conversion to DHT (& Arimidex to limit estradiol).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Bicalutamide (Casodex) plus Dutasteride (Avodart)
The rationale behind the combination of Casodex & Avodart was articulated in a 2009 paper [2]: "Bicalutamide blocks androgen action in men with prostate cancer but has low affinity for the androgen receptor compared to
dihydrotestosterone
(DHT).
The rationale behind the combination of Casodex & Avodart was articulated in a 2009 paper [2]: "Bicalutamide blocks androgen action in men with prostate cancer but has low affinity for the androgen receptor compared to
dihydrotestosterone
(DHT).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Foods/Supplements-Vitamins: Capsaicin - Cayenne
Promoter assays showed that capsaicin inhibited the ability of
dihydrotestosterone
to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct
Promoter assays showed that capsaicin inhibited the ability of
dihydrotestosterone
to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct
pjoshea13
in
Advanced Prostate Cancer
8 years ago
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