Experiences with

Dihydrotestosterone

Finasteride - oral tablets - These are hormone blockers designed to block dihydrotestosterone and preserve the feminine locks i used to have, which is all well and good, but it can cause sexual dysfunction, breast enlargement, depression, and it's what they give to men undergoing gender reassignment

After learning that prostate cancer cells only respond to dihydrotestosterone (DHT) and not to testosterone directly (DHT is made from testosterone), I decided to go on Dutasteride on 12/1/23.

[/i] [i]The study also examined outcomes related to sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone (DHT), and estradiol concentrations.

"Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone" https://pubmed.ncbi.nlm.nih.gov/26923074/ To me, you might as well be taking low-dose Finasteride and save some money versus buying BROQ. LOL. Not to say Sulforphane may have other benefits.

While testosterone will convert to dihydrotestosterone [DHT] in the absence of Avodart, say, DHT is one's friend - until it isn't, imo. As with the vitamin D conversion of 25-D to 1,25-D, the presence of the strong hormone triggers its decay in prostatic cells.

Even though I am still taking Avodart, which I believe can increase Testosterone, because Avodart blocks the conversion of Testosterone to dihydroTestosterone, (DHT), that would leave more testosterone because it doesn't get converted to DHT.

“In support of the physiological significance of this MYC repression, we found DHT (dihydrotestosterone) treatment of CRPC xenografts could rapidly suppress MYC, a response that may contribute to the efficacy of supraphysiological androgen therapy in CRPC.

The natural ligand for ERβ is a metabolite of dihydrotestosterone [DHT]. While the new paper is only of passing interest to most (if at all), I have posted because mention of estrogen receptors in male tissue is so rare. -Patrick [1]  https://pubmed.ncbi.nlm.nih.gov/36742361/ 

"Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher intratumor dihydrotestosterone (DHT) concentration than that of treatment responsive tumors."

Testosterone, Androstendeione, Dihydrotestosterone (DHT) https://nutritionallyyourstestkits.com/product/female-saliva-hormones-adrenals/ You receive the results, no doctors order needed!

These results suggested the potential function of GPM6B as a diagnostic marker of PCa and provided clues for the development of new treatment targets for PCa. https://pubmed.ncbi.nlm.nih.gov/33294057 and Methylprednisolone increase GPM6B expression.

The "high-dose-androgen" used in the study was , DHT.

Component DHT, LC-MS/MS Your Value <2.5 pg/mL Standard Range 106.0 - 719.0 pg/mL http://www.theprostateadvocate.com/pdf/DIHYDROTESTOSTERONE%20DHT%20CONTROVERSY.pdf

Two common androgens are testosterone and the more powerful dihydrotestosterone (DHT). 2. Men deficient in an enzyme called 5-alpha-reductase type 2 don’t develop an enlarged prostate (also called benign prostatic hyperplasia, or BPH) or prostate cancer.

In the past my MO has used 82651 and G0480. Now Medicare wants to charge me $1,000 to have the test done.

The 5-alpha-reductase inhibitors( 5ARIs)are widely used in the treatment of benign prostatic hyperplasia(BPH)by biological function of inhibiting the conversion from testosterone to dihydrotestosterone.

In mice, these androgen-producing bacteria can be targeted to slow progression from HSPC to CRPC." [2] Microbes hijack prostate cancer therapy "Androgens such as testosterone and dihydrotestosterone are essential for male reproduction and sexual function.

[1] Note: 5α-Reductase Inhibitors [5ARIs] - such as Dutasteride [Avodart] - inhibit the conversion of testosterone to dihydrotestosterone [DHT]. "SARS-CoV-2 has a disproportionately severe effect on men, suggesting that the androgen pathway plays a role in the disease.

However, to place the magnitude of this change in context, a 125% change in serum T levels in hypogonadal men treated with T replacement therapy (baseline 282 ng/dL [9.8 nmol/L]; 6 months, 640 ng/dL [22.2 nmol/L]) was associated with no difference in prostate tissue levels of T and dihydrotestosterone

Another escape pathway is the manufacture of DHT (dihydrotestosterone) via the alternate pathway that does not require testosterone, Avodart will inhibit that.