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Dihydrotestosterone
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Thoughts on BAT
I know some readers supplement with finasteride (Proscar) and dutasteride (Avodart), 2 old antiandrogens that inhibit 5-alphareductase (5AR) and prevent the formation of
dihydrotestosterone
(DHT), a very powerful androgen that our cancers love.
I know some readers supplement with finasteride (Proscar) and dutasteride (Avodart), 2 old antiandrogens that inhibit 5-alphareductase (5AR) and prevent the formation of
dihydrotestosterone
(DHT), a very powerful androgen that our cancers love.
kaptank
in
Advanced Prostate Cancer
6 years ago
Dutasteride [Avodart] & Abiraterone [Zytiga]?
.{&}... works by decreasing the production of
dihydrotestosterone
(DHT) ..." (from testosterone). [1] It is not approved for treating PCa. When I initially asked for a prescription, my doctor warned me that I might have a problem getting insurance to pay for it, but that was not the case.
.{&}... works by decreasing the production of
dihydrotestosterone
(DHT) ..." (from testosterone). [1] It is not approved for treating PCa. When I initially asked for a prescription, my doctor warned me that I might have a problem getting insurance to pay for it, but that was not the case.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Dihydrotestosterone [DHT] & PCa castration resistance [CRPC].
Of note, glucuronidation-incompetent cells and the resultant loss of intracellular conjugated
dihydrotestosterone
were detectable in vivo by 18F-
dihydrotestosterone
PET.
Of note, glucuronidation-incompetent cells and the resultant loss of intracellular conjugated
dihydrotestosterone
were detectable in vivo by 18F-
dihydrotestosterone
PET.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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PCa Abbreviation List UPDATED 1/26/2023
creatinine •CRYO = cryotherapy, cryoablation, cryosurgery •CS = clinical stage •CT SCAN = computerized tomography (also known as CAT scan or CT scan) •D = diploid •DART = dynamic adaptive radiation therapy •DES = diethylstilbestrol (an estrogen) •DHEA = dihydroepiandrosterone •DHEA-S = DHEA sulfate •DHT =
dihydrotestosterone
creatinine •CRYO = cryotherapy, cryoablation, cryosurgery •CS = clinical stage •CT SCAN = computerized tomography (also known as CAT scan or CT scan) •D = diploid •DART = dynamic adaptive radiation therapy •DES = diethylstilbestrol (an estrogen) •DHEA = dihydroepiandrosterone •DHEA-S = DHEA sulfate •DHT =
dihydrotestosterone
Moespy
in
Advanced Prostate Cancer
6 years ago
Androgen Annihilation.
explains it well: "Androgens may be “annihilated” using simultaneously a luteinizing hormone releasing hormone (LHRH) antagonist or agonist to inhibit testicular production of testosterone, a cytochrome P45017A1 (CYP17A1) inhibitor to diminish metabolism of testosterone via the adrenal pathway and
dihydrotestosterone
explains it well: "Androgens may be “annihilated” using simultaneously a luteinizing hormone releasing hormone (LHRH) antagonist or agonist to inhibit testicular production of testosterone, a cytochrome P45017A1 (CYP17A1) inhibitor to diminish metabolism of testosterone via the adrenal pathway and
dihydrotestosterone
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Melatonin - Review.
As prostate physiology is under the control of androgens (testosterone and
dihydrotestosterone
) and their metabolites, androgen deprivation therapy (by inhibition of hormone biosynthesis or androgen receptor deprivation) has been extensively used in PC.
As prostate physiology is under the control of androgens (testosterone and
dihydrotestosterone
) and their metabolites, androgen deprivation therapy (by inhibition of hormone biosynthesis or androgen receptor deprivation) has been extensively used in PC.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
DHEA & Drug Resistance.
For DHEA-SO4 to be utilized there is uptake by organic anion transporter polypeptides, deconjugation catalyzed by steroid sulfatase, and adaptive upregulation of prostate steroidogenic enzymes that will convert DHEA into either testosterone or
dihydrotestosterone
.
For DHEA-SO4 to be utilized there is uptake by organic anion transporter polypeptides, deconjugation catalyzed by steroid sulfatase, and adaptive upregulation of prostate steroidogenic enzymes that will convert DHEA into either testosterone or
dihydrotestosterone
.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
low tsh,t3,t4. low sex hormones too.
Below are my results: TESTOSTERONE, FREE1 104.8 pg/mL 46.0-224.0 DHEA SULFATE2 345 mcg/dL 85-690 TESTOSTERONE, TOTAL, MALES (ADULT), IA2 542 ng/dL 250-827 SEX HORMONE BINDING GLOBULIN2 20 nmol/L 10-50
DIHYDROTESTOSTERONE
, LC/MS/MS3 25 ng/dL 16-79 DHT, FREE3 2.12 pg/mL ESTRADIOL,
Below are my results: TESTOSTERONE, FREE1 104.8 pg/mL 46.0-224.0 DHEA SULFATE2 345 mcg/dL 85-690 TESTOSTERONE, TOTAL, MALES (ADULT), IA2 542 ng/dL 250-827 SEX HORMONE BINDING GLOBULIN2 20 nmol/L 10-50
DIHYDROTESTOSTERONE
, LC/MS/MS3 25 ng/dL 16-79 DHT, FREE3 2.12 pg/mL ESTRADIOL,
hypossee
in
Thyroid UK
6 years ago
5α-reductase inhibitors for benign prostate hypertrophy and risk of high-grade prostate cancer
While 5alpha-reductase inhibitors (5-ARIs) reduce
dihydrotestosterone
[DHT], they also reduce the beneficial DHT metabolite that is the natural ligand for the protective beta estrogen receptor [ERbeta]. Time passed & there was no excess mortality in either treatment arm.
While 5alpha-reductase inhibitors (5-ARIs) reduce
dihydrotestosterone
[DHT], they also reduce the beneficial DHT metabolite that is the natural ligand for the protective beta estrogen receptor [ERbeta]. Time passed & there was no excess mortality in either treatment arm.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Pygeum and PSA
I read: ‘Unlike the drug finisteride, pygeum does not appear to work by affecting the conversion of testosterone to
dihydrotestosterone
; but rather, it is thought to reduce inflammation in the prostate and to inhibit prostate growth factors, substances implicated in inappropriate prostate enlargement
I read: ‘Unlike the drug finisteride, pygeum does not appear to work by affecting the conversion of testosterone to
dihydrotestosterone
; but rather, it is thought to reduce inflammation in the prostate and to inhibit prostate growth factors, substances implicated in inappropriate prostate enlargement
900312611
in
Advanced Prostate Cancer
6 years ago
Testosterone metabolites inhibit proliferation of castration- and therapy-resistant PCa.
I mention elsewhere how in normal prostatic cells, the presence of growth-stimulating
dihydrotestosterone
[DHT] induces an enzyme for its rapid clearance, & that a DHT metabolite - 3beta-adiol - is the natural ligand for an estrogen (!) receptor, ERbeta.
I mention elsewhere how in normal prostatic cells, the presence of growth-stimulating
dihydrotestosterone
[DHT] induces an enzyme for its rapid clearance, & that a DHT metabolite - 3beta-adiol - is the natural ligand for an estrogen (!) receptor, ERbeta.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Backdoor Dihydrotestosterone [DHT] & CRPC.
KEYWORDS: 3α-oxidoreductases; androgen deprivation therapy; androstanediol;
dihydrotestosterone
; dutasteride PMID: 29541409 PMCID: PMC5834294 DOI: 10.18632/oncotarget.24107
KEYWORDS: 3α-oxidoreductases; androgen deprivation therapy; androstanediol;
dihydrotestosterone
; dutasteride PMID: 29541409 PMCID: PMC5834294 DOI: 10.18632/oncotarget.24107
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Polyphenols - Inflammation.
Some derivatives of CA have also shown potent cytotoxic and anti-proliferative effects and
dihydrotestosterone
(DHT)-stimulated prostate specific antigen (PSA) secretion [22].
Some derivatives of CA have also shown potent cytotoxic and anti-proliferative effects and
dihydrotestosterone
(DHT)-stimulated prostate specific antigen (PSA) secretion [22].
pjoshea13
in
Advanced Prostate Cancer
6 years ago
PSA & the Sun
In a post hoc analysis, serum testosterone levels were increased in men with MC1R rs1805007 and serum
dihydrotestosterone
in men with ASIP rs1015362. CONCLUSION: Men with SNPs in SLC45A2, who have less sun sensitive skin, have lower PSA levels.
In a post hoc analysis, serum testosterone levels were increased in men with MC1R rs1805007 and serum
dihydrotestosterone
in men with ASIP rs1015362. CONCLUSION: Men with SNPs in SLC45A2, who have less sun sensitive skin, have lower PSA levels.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Blood Test - How do they work?
I need to supply the doctor Im seeing with the follow bloods: "LFTs, lipids, glucose, vitamin D, FBC, LH, FSH, SHBG, oestradiol, testosterone,
dihydrotestosterone
, prostate specific antigen."
I need to supply the doctor Im seeing with the follow bloods: "LFTs, lipids, glucose, vitamin D, FBC, LH, FSH, SHBG, oestradiol, testosterone,
dihydrotestosterone
, prostate specific antigen."
LucasElijah
in
Thyroid UK
7 years ago
CRPC & Avodart [Dutasteride].
Abstract It has previously been demonstrated that the intratumoral generation of the potent androgen
dihydrotestosterone
(DHT), contributes critically to the progression of prostate cancer and its castration-resistant form, castration-resistant prostate cancer (CRPC).
Abstract It has previously been demonstrated that the intratumoral generation of the potent androgen
dihydrotestosterone
(DHT), contributes critically to the progression of prostate cancer and its castration-resistant form, castration-resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Jevtana [Cabazitaxel] & Androgen Status.
For instance, there is a potential pathway that produces DHT (
dihydrotestosterone
) but not via the usual T (testosterone) path. Also, PCa cells accumulate cholesterol, which potentially can be used to produce any of the steroid hormones.
For instance, there is a potential pathway that produces DHT (
dihydrotestosterone
) but not via the usual T (testosterone) path. Also, PCa cells accumulate cholesterol, which potentially can be used to produce any of the steroid hormones.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Xtandi/Enzalutamide & Curcumin/Turmeric
{
Dihydrotestosterone
[DHT] (the natural AR ligand) strongly competes with Xtandi for AR binding, so it is just as well to use Avodart, even with castrate testosterone [T], since PCa has been known to manufacture DHT via a back-door path that does not involve T.}
{
Dihydrotestosterone
[DHT] (the natural AR ligand) strongly competes with Xtandi for AR binding, so it is just as well to use Avodart, even with castrate testosterone [T], since PCa has been known to manufacture DHT via a back-door path that does not involve T.}
pjoshea13
in
Advanced Prostate Cancer
7 years ago
How can I get a more sensitive Dihydrotestosterone (DHT) score?
Collaborative Laboratory Services subcontracts the
Dihydrotestosterone
(DHT) part of my blood work out to the blood service conducted by Mayo Clinic Laboratories. When DHT is lower than 50 they report >50; I want to know the true score.
Collaborative Laboratory Services subcontracts the
Dihydrotestosterone
(DHT) part of my blood work out to the blood service conducted by Mayo Clinic Laboratories. When DHT is lower than 50 they report >50; I want to know the true score.
BigRich
in
Advanced Prostate Cancer
7 years ago
Father, stage 4
Can any hormone therapy or something that suppresses testosterone or
dihydrotestosterone
(casodex, ketonazole, avodart...) help him or is his PC castrate - resistant? Zytiga and Xtandi are not possibe as long-term treatment for financial reasons.
Can any hormone therapy or something that suppresses testosterone or
dihydrotestosterone
(casodex, ketonazole, avodart...) help him or is his PC castrate - resistant? Zytiga and Xtandi are not possibe as long-term treatment for financial reasons.
Novak
in
Advanced Prostate Cancer
7 years ago
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