Search
Search
About
Log in
Join
Experiences with
Denosumab
Posts
Communities
239 public posts
Filter results
Bisphosphonates & Prolia -- DANGEROUS
The new line of drugs are called
Denosumab
(of which Prolia is very popular). Arguebly, the new drugs are worse because they go upstream and suppress precursor proteins such as something called RANKL or RANK ligand -- which has many functions other than just activating osteoclasts.
The new line of drugs are called
Denosumab
(of which Prolia is very popular). Arguebly, the new drugs are worse because they go upstream and suppress precursor proteins such as something called RANKL or RANK ligand -- which has many functions other than just activating osteoclasts.
SandyABC
in
Bone Health and Osteoporosis UK
5 years ago
Xgeva / calcium & vitamin D.
Severe hypocalcaemia is a rare and dangerous side effect of
denosumab
. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcaemia after receiving a single dose of
denosumab
.
Severe hypocalcaemia is a rare and dangerous side effect of
denosumab
. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcaemia after receiving a single dose of
denosumab
.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Medication for bone mets
In 2 weeks I start
denosumab
(prolia) because of bone Mets. This is really frightening me, esp. Jaw risks. How did others find it?
In 2 weeks I start
denosumab
(prolia) because of bone Mets. This is really frightening me, esp. Jaw risks. How did others find it?
Rotagirl
in
SHARE Metastatic Breast Cancer
6 years ago
Want to take advantage of all our features? Just log in!
Log in
or
Join
Parkinsons and Osteoporosis medications
This time they suggest a 6 monthly injection of something called
denosumab
. Does anyone else here juggle with these two conditions? I take Madopar for Parkinsons, which works well for me, and am reluctant to possibly complicate things with other medication.
This time they suggest a 6 monthly injection of something called
denosumab
. Does anyone else here juggle with these two conditions? I take Madopar for Parkinsons, which works well for me, and am reluctant to possibly complicate things with other medication.
ge1shh
in
Cure Parkinson's
6 years ago
Stopping Denosumab Prolia
It was not until September The European Medicines Agency (EMA) revised their advice – patients either being offered alterative medication or to continue with
denosumab
. Posy White
It was not until September The European Medicines Agency (EMA) revised their advice – patients either being offered alterative medication or to continue with
denosumab
. Posy White
Posy-White
in
Bone Health and Osteoporosis UK
6 years ago
Bloody nose
I started on Ibrance 125mg, letrozole and
denosumab
injections three weeks ago. Apart from a woolly head and aches and pains this is the only other side effect.
I started on Ibrance 125mg, letrozole and
denosumab
injections three weeks ago. Apart from a woolly head and aches and pains this is the only other side effect.
StE72
in
SHARE Metastatic Breast Cancer
6 years ago
Hi Everyone i'm a Newbie with Mets to Bone , Lymph Node and Liver?
Started on Ibrance , Letrozole and
Denosumab
and due to have first scan soon , which i think is going to be the scary part. Hearing good things about Ibrance , so staying positive this will work for me also.
Started on Ibrance , Letrozole and
Denosumab
and due to have first scan soon , which i think is going to be the scary part. Hearing good things about Ibrance , so staying positive this will work for me also.
Hidden
in
SHARE Metastatic Breast Cancer
6 years ago
Metastasis-free Survival - Enzalutamide.
In 2012, another ODAC examined the results of
denosumab
use in a randomized, placebo-controlled trial involving 1432 men with nmCRPC. This trial demonstrated an estimated median improvement of only 4 months in bone-only metastasis-free survival.
In 2012, another ODAC examined the results of
denosumab
use in a randomized, placebo-controlled trial involving 1432 men with nmCRPC. This trial demonstrated an estimated median improvement of only 4 months in bone-only metastasis-free survival.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
HELLO, I AM NEW HERE
Been advised to used
Denosumab
or maybe get teriparatide. I suffer bad gastritis and have gallstones, so cant tolerate pills on stomach. I don't like the sound of the side effects from these drugs, as I am very med sensitive as are a lot of people wit autoimmune problems and CFS.
Been advised to used
Denosumab
or maybe get teriparatide. I suffer bad gastritis and have gallstones, so cant tolerate pills on stomach. I don't like the sound of the side effects from these drugs, as I am very med sensitive as are a lot of people wit autoimmune problems and CFS.
cmoc
in
Bone Health and Osteoporosis UK
6 years ago
Maybe the answer is to not start denosumab?
Seems to be virtually impossible to safely discontinue
denosumab
after starting it. Maybe the solution is to not start it in the first place? Certainly it should not be prescribed to younger patients who may therefore spend decades on this medication.
Seems to be virtually impossible to safely discontinue
denosumab
after starting it. Maybe the solution is to not start it in the first place? Certainly it should not be prescribed to younger patients who may therefore spend decades on this medication.
HeronNS
in
Bone Health and Osteoporosis UK
6 years ago
Prevalence of Osteonecrosis of the Jaw [ONJ].
KEYWORDS: bisphosphonate; breast cancer;
denosumab
; multiple myeloma; osteonecrosis; prostate cancer PMID: 29563474 DOI: 10.3390/dj4040032
KEYWORDS: bisphosphonate; breast cancer;
denosumab
; multiple myeloma; osteonecrosis; prostate cancer PMID: 29563474 DOI: 10.3390/dj4040032
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Need some help
I was diagnosed December 2012 age 53 Gleason 9 PSA 3.6 no symptoms just the result of a well man check up My bone scan at diagnosis is below, i will list my treatments so far Jan 13, 9 cycles Docetaxel,
Denosumab
, Zoladex and 5 days of RT to pelvis to prevent fracture After finishing Chemo i went straight
I was diagnosed December 2012 age 53 Gleason 9 PSA 3.6 no symptoms just the result of a well man check up My bone scan at diagnosis is below, i will list my treatments so far Jan 13, 9 cycles Docetaxel,
Denosumab
, Zoladex and 5 days of RT to pelvis to prevent fracture After finishing Chemo i went straight
siness
in
Advanced Prostate Cancer
6 years ago
Denosumab problems
Discontinuing
denosumab
(Prolia) can lead to vertebral fracture, apparently not related to the underlying osteoporosis, but to the development of microcracks in the bones from
denosumab
. Advice is to replace
denosumab
, not go cold turkey off the med.
Discontinuing
denosumab
(Prolia) can lead to vertebral fracture, apparently not related to the underlying osteoporosis, but to the development of microcracks in the bones from
denosumab
. Advice is to replace
denosumab
, not go cold turkey off the med.
HeronNS
in
PMRGCAuk
6 years ago
Have you taken bone strengthening meds since being on ADT?
I'm wondering how many of those who have bone mets, and are taking ADT have also taken or are taking bone strengthening meds such as Zolendronic Acid (Zometa) or
Denosumab
(Xgeva). I've taken one infusion of Zolendronic Acid so far, but will discuss continuing it with my doctor next week.
I'm wondering how many of those who have bone mets, and are taking ADT have also taken or are taking bone strengthening meds such as Zolendronic Acid (Zometa) or
Denosumab
(Xgeva). I've taken one infusion of Zolendronic Acid so far, but will discuss continuing it with my doctor next week.
Hidden
in
Advanced Prostate Cancer
6 years ago
my journey
Have had radiation, tried zolodex then 20 treatments docetaxel then 68 treatments cabazitaxel chemo ended 1yr ago.numerous viscious side effects. currently on elligard and
denosumab
feeling great, little tired on elligard.
Have had radiation, tried zolodex then 20 treatments docetaxel then 68 treatments cabazitaxel chemo ended 1yr ago.numerous viscious side effects. currently on elligard and
denosumab
feeling great, little tired on elligard.
Izab
in
Advanced Prostate Cancer
6 years ago
New member
I have been on letrozole and
denosumab
injections since then and have now just started ibrance, worried about side effects and how soon do they kick off
I have been on letrozole and
denosumab
injections since then and have now just started ibrance, worried about side effects and how soon do they kick off
Olga1962
in
SHARE Metastatic Breast Cancer
7 years ago
Denosumab (Prolia) injection - has anyone had any experience with it?
Hi I haven't posted for a while. I had breast cancer back in May 2014 and had a total mastectomy and lymph node removal. Although at the time no mets were found at a later CT scan a "shadow " was found on my spine (this was about 18 months ago). A PET scan revealed it was not active and my oncologist
Hi I haven't posted for a while. I had breast cancer back in May 2014 and had a total mastectomy and lymph node removal. Although at the time no mets were found at a later CT scan a "shadow " was found on my spine (this was about 18 months ago). A PET scan revealed it was not active and my oncologist
Dmhaynes
in
My Breast Cancer Community
7 years ago
Bone Health and Bone-Targeted Therapies for Nonmetastatic PCa.
Conclusion: Both bisphosphonates and
denosumab
improve BMD in men with nonmetastatic prostate cancer who are receiving ADT.
Denosumab
also reduces risk for radiographic vertebral fractures, based on 1 trial. More trials studying fracture outcomes are needed in this population.
Conclusion: Both bisphosphonates and
denosumab
improve BMD in men with nonmetastatic prostate cancer who are receiving ADT.
Denosumab
also reduces risk for radiographic vertebral fractures, based on 1 trial. More trials studying fracture outcomes are needed in this population.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Please help!
I do not wish to delay the start of chemo and wondered if anyone knows if the injection of
Denosumab
which I am supposed to be having might be sufficient in order to not have the pinning so that chemo can go ahead as planned. I really think it is important to start my chemo.
I do not wish to delay the start of chemo and wondered if anyone knows if the injection of
Denosumab
which I am supposed to be having might be sufficient in order to not have the pinning so that chemo can go ahead as planned. I really think it is important to start my chemo.
nicky8
in
The Roy Castle Lung Cancer Foundation
7 years ago
Preparing for Round Two
My urologist put me on Zoladex (goserelin) and a bone strengthener Prolia (
Denosumab
). The effect was immediate and my PSA plummeted to undetectable. When it started to rise, my oncologist placed me on bi-calutamide and once again it went down to undetectable again.
My urologist put me on Zoladex (goserelin) and a bone strengthener Prolia (
Denosumab
). The effect was immediate and my PSA plummeted to undetectable. When it started to rise, my oncologist placed me on bi-calutamide and once again it went down to undetectable again.
RyderLake2
in
Advanced Prostate Cancer
7 years ago
1
...
10
11
12
Next page
10
Filter results
Clear filters
Posted in
All communities
SHARE Metastatic Breast Cancer
74 results
Advanced Prostate Cancer
56 results
Bone Health and Osteoporosis UK
39 results
View top 10 communities
Sort by
Most Relevant
Newest