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Degarelix
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ASCO 2023 Poster: Androgen-deprivation therapy and risk of dementia in patients with prostate cancer:Clinical outcomes from real-world data.
The highest risk was witnessed with GnRH antagonists (
degarelix
), with a 92% increased risk. Interestingly, the increased risk of dementia in ADT groups was observed only among whites but not in African Americans.
The highest risk was witnessed with GnRH antagonists (
degarelix
), with a 92% increased risk. Interestingly, the increased risk of dementia in ADT groups was observed only among whites but not in African Americans.
rsgdmd
in
Advanced Prostate Cancer
1 year ago
PSA Doubling Time
Have had a prostatectomy, radiation, Zolodex and finished 8 months of
degarelix
end of Aug. By 25 Oct my PSA was 0.44. On 15 Dec it was 1.99 and 18 days later on 03 Jan it was 2.84. By my Oncologist’s calculation my doubling time is 8 months.
Have had a prostatectomy, radiation, Zolodex and finished 8 months of
degarelix
end of Aug. By 25 Oct my PSA was 0.44. On 15 Dec it was 1.99 and 18 days later on 03 Jan it was 2.84. By my Oncologist’s calculation my doubling time is 8 months.
MGBman
in
Advanced Prostate Cancer
1 year ago
Rising PSA Again! What Next? Any Thoughts?
Then had 9
degarelix
injections ending Aug 2022. PSA down to 0.31. By Oct PSA was rising and by mid Dec was 2.0. Over the past two yrs have had PSMA Pet and internal MRI - no identifiable mets, just one 2cm tumour residing along vas deferens.
Then had 9
degarelix
injections ending Aug 2022. PSA down to 0.31. By Oct PSA was rising and by mid Dec was 2.0. Over the past two yrs have had PSMA Pet and internal MRI - no identifiable mets, just one 2cm tumour residing along vas deferens.
MGBman
in
Advanced Prostate Cancer
2 years ago
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doc says 9-12 months more for my dad
He was diagnosed with PCa in November - started triplet therapy right away (Docetaxel, Enzalutamide &
degarelix
) his PSA dropped to negligible from over 200. he started experiencing pain in his abdomen last month or so.
He was diagnosed with PCa in November - started triplet therapy right away (Docetaxel, Enzalutamide &
degarelix
) his PSA dropped to negligible from over 200. he started experiencing pain in his abdomen last month or so.
A-rat-22
in
Advanced Prostate Cancer
1 year ago
raising the topic of a hormone holiday after July
visit to London MO today for more hormones ( switched to 3 month Zolodex because last months
Degarelix
injection is still a nasty swollen red lump on my stomach) I picked up my Apalutamide and had blood tests as ever with a face to face consult.
visit to London MO today for more hormones ( switched to 3 month Zolodex because last months
Degarelix
injection is still a nasty swollen red lump on my stomach) I picked up my Apalutamide and had blood tests as ever with a face to face consult.
Brysonal
in
Fight Prostate Cancer
1 year ago
OVM-200 Phase 1 clinical trial ( vaccine)
This trial allows me to stay on my hormone therapy so monthly
Degarelix
injection and daily Apalutamide continue. My PSA remained undetectable for the fifth month since my treatment package ended in June.
This trial allows me to stay on my hormone therapy so monthly
Degarelix
injection and daily Apalutamide continue. My PSA remained undetectable for the fifth month since my treatment package ended in June.
Brysonal
in
Fight Prostate Cancer
2 years ago
PSA hovering around 1 even after a year on ADT + Enza, should we insist on Triplet Therapy ?
His treatment started off with 10 sessions of Palliative RT followed by combination of
Degarelix
+ Enzaluatmide + Denosumab repeating every 28 days.
His treatment started off with 10 sessions of Palliative RT followed by combination of
Degarelix
+ Enzaluatmide + Denosumab repeating every 28 days.
dudubaya
in
Advanced Prostate Cancer
2 years ago
Another vacation?
I was put on
degarelix
after 6 mos biological recurrence. A 2019 Auxumin scan showed small malignancy and lymph node involvement. I changed MO's in order to try intermittent ADT, hence the third vacation.
I was put on
degarelix
after 6 mos biological recurrence. A 2019 Auxumin scan showed small malignancy and lymph node involvement. I changed MO's in order to try intermittent ADT, hence the third vacation.
kainasar
in
Advanced Prostate Cancer
2 years ago
OVM-200 clinical trial
Back from a great holiday now and had my 4th non detectable PSA result last Friday so 11th
Degarelix
injection followed plus Apalutamide pick up. Online consult today with MO so have asked his thoughts on this vaccine trial.
Back from a great holiday now and had my 4th non detectable PSA result last Friday so 11th
Degarelix
injection followed plus Apalutamide pick up. Online consult today with MO so have asked his thoughts on this vaccine trial.
Brysonal
in
Fight Prostate Cancer
2 years ago
Triplet Regimen vs Clinical Trial (Pluvicto)
I met with my oncologist at Sloan Kettering on March 23rd and received my first hormone treatment (
Degarelix
). My PSA has already dropped from 189 to 23.89, and I had my second hormone treatment, which was a shot of Lupron, on April 18th.
I met with my oncologist at Sloan Kettering on March 23rd and received my first hormone treatment (
Degarelix
). My PSA has already dropped from 189 to 23.89, and I had my second hormone treatment, which was a shot of Lupron, on April 18th.
Bruce98
in
Advanced Prostate Cancer
1 year ago
0VM-200 clinical trial
SBRT, VMAT and two Brachi boosts Now just my monthly
Degarelix
injection and daily Apa . I hate having no testosterone ( but better than last Nov mets popping up everywhere). Please let the science come tgat allows us to have testosterone!
SBRT, VMAT and two Brachi boosts Now just my monthly
Degarelix
injection and daily Apa . I hate having no testosterone ( but better than last Nov mets popping up everywhere). Please let the science come tgat allows us to have testosterone!
Brysonal
in
Fight Prostate Cancer
2 years ago
PSA rising - When to get a PSMA PET scan?
A year of
Degarelix
(Firmagon) + Apalutamide (Erleada) bought me more than 2 years of undetectable PSA. Now the PSA is climbing past 0.5 with a doubling time of about 5.5 months so a GA68 PSMA PET scan is probably the next move. I wonder how long to wait before getting the scan.
A year of
Degarelix
(Firmagon) + Apalutamide (Erleada) bought me more than 2 years of undetectable PSA. Now the PSA is climbing past 0.5 with a doubling time of about 5.5 months so a GA68 PSMA PET scan is probably the next move. I wonder how long to wait before getting the scan.
Revcat
in
Advanced Prostate Cancer
1 year ago
PSA increase in less than two months of ADT
He was given Firmagon (
Degarelix
240mg) on Dec.2. His PSA dropped to 500 on Dec.28. He's been much better since. January 2: Second dose of Firmagon 80mg. We finally got to see an oncologist two days ago, who recommends Zytiga and Chemo concurrently as soon as possible.
He was given Firmagon (
Degarelix
240mg) on Dec.2. His PSA dropped to 500 on Dec.28. He's been much better since. January 2: Second dose of Firmagon 80mg. We finally got to see an oncologist two days ago, who recommends Zytiga and Chemo concurrently as soon as possible.
Sissel25
in
Advanced Prostate Cancer
1 year ago
67 yo dad with stage 4 PC
He has started hormone therapy with
Degarelix
and already received his first round of chemo Docetaxel. He will be doing 5 more rounds of chemo every 2 weeks and then reviewed further to see how he is responding. His oncologist’s notes read - intent of treatment is palliative and non curative.
He has started hormone therapy with
Degarelix
and already received his first round of chemo Docetaxel. He will be doing 5 more rounds of chemo every 2 weeks and then reviewed further to see how he is responding. His oncologist’s notes read - intent of treatment is palliative and non curative.
A-rat-22
in
Advanced Prostate Cancer
2 years ago
Seeing the < sign!
I know it’s all about stability but still after 7 months of
Degarelix
, 3 x Lu-177, 3 x Docetaxel, 20 VMAT rounds , 2 brachytherapy’s and 1 month of Apalutamide it was a good day! Feel like I should have ended that list with ‘and a partridge in a pear tree’! It’s been a mad 7 months!
I know it’s all about stability but still after 7 months of
Degarelix
, 3 x Lu-177, 3 x Docetaxel, 20 VMAT rounds , 2 brachytherapy’s and 1 month of Apalutamide it was a good day! Feel like I should have ended that list with ‘and a partridge in a pear tree’! It’s been a mad 7 months!
Brysonal
in
Advanced Prostate Cancer
2 years ago
Am I missing any options / pipeline developments that could allow me to stop HT?
I am on monthly
Degarelix
and daily Abiraterone. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
I am on monthly
Degarelix
and daily Abiraterone. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
Brysonal
in
Advanced Prostate Cancer
2 years ago
Supplements now treatment is over
After a combination of
Degarelix
, 3x Lu-177, 3 x Docetaxel my PSA was 98% reduced to 0.19 and scans showed a strong response but some activity remained so I followed up with 3x SBRT to T9 which was still showing ( a much reduced 1.5 SUV) and 20 lots of VMAT radiation to prostate and oelvic area and a
After a combination of
Degarelix
, 3x Lu-177, 3 x Docetaxel my PSA was 98% reduced to 0.19 and scans showed a strong response but some activity remained so I followed up with 3x SBRT to T9 which was still showing ( a much reduced 1.5 SUV) and 20 lots of VMAT radiation to prostate and oelvic area and a
Brysonal
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Note that the LHRH antagonists
degarelix
and relugolix do not have the androgen flare. The article referenced is worth careful consideration by anyone here contemplating salvage radiation therapy to prostate, pelvic node fields and or oligometastatic SBRT.
Note that the LHRH antagonists
degarelix
and relugolix do not have the androgen flare. The article referenced is worth careful consideration by anyone here contemplating salvage radiation therapy to prostate, pelvic node fields and or oligometastatic SBRT.
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
Note that the LHRH antagonists
degarelix
and relugolix do not have the androgen flare. The article referenced is worth careful consideration by anyone here contemplating salvage radiation therapy to prostate, pelvic node fields and or oligometastatic SBRT.
Note that the LHRH antagonists
degarelix
and relugolix do not have the androgen flare. The article referenced is worth careful consideration by anyone here contemplating salvage radiation therapy to prostate, pelvic node fields and or oligometastatic SBRT.
MateoBeach
in
Fight Prostate Cancer
2 years ago
Lasting Degarelix reaction
Can there be tissue swelling around the injection site from
degarelix
5 plus weeks from the initial injection? This was 5 weeks ago with a Lupron injection last week. Only reaction to the Lupron so far was itching.
Can there be tissue swelling around the injection site from
degarelix
5 plus weeks from the initial injection? This was 5 weeks ago with a Lupron injection last week. Only reaction to the Lupron so far was itching.
MountainMamma
in
Prostate Cancer Network
2 years ago
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