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Foods/Supplements-Vitamins: D - Cholecalciferol/Calcidiol/Calcitriol - U-shaped Risk
Cholecalciferol is processed by the liver to produce the prohormone
calcidiol
[25(OH)D3]. The hormonal form, calcitriol [1α,25(OH)2D3], is produced from
calcidiol
, primarily by the kidneys, as needed. The main vitamin D blood test is for
calcidiol
, the inactive reservoir.
Cholecalciferol is processed by the liver to produce the prohormone
calcidiol
[25(OH)D3]. The hormonal form, calcitriol [1α,25(OH)2D3], is produced from
calcidiol
, primarily by the kidneys, as needed. The main vitamin D blood test is for
calcidiol
, the inactive reservoir.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Calcium Sensing Receptor [CaSR]
The conventional view on calcium in PCa is that it interferes with vitamin D conversion by the kidneys (
calcidiol
to calcitriol ... aka 25(OH)D to 1,25(OH)D) that is essential if PCa is to be treated vith vitamin D. PCa cells lose the ability to do the conversion.
The conventional view on calcium in PCa is that it interferes with vitamin D conversion by the kidneys (
calcidiol
to calcitriol ... aka 25(OH)D to 1,25(OH)D) that is essential if PCa is to be treated vith vitamin D. PCa cells lose the ability to do the conversion.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
New to insulin and Cholesterol has increased- Diet better
Hi I have been on statins for 8 years , my diet was poor, smoked, little or no exercise diagnosed diabetes type 2, high cholesterol and high blood pressure. I quit smoking, lost 3-4 stone and overhauled my diet and exercised a little more. For the last six years my cholesterol has been 3.8. Two
Hi I have been on statins for 8 years , my diet was poor, smoked, little or no exercise diagnosed diabetes type 2, high cholesterol and high blood pressure. I quit smoking, lost 3-4 stone and overhauled my diet and exercised a little more. For the last six years my cholesterol has been 3.8. Two
jobey30
in
Cholesterol Support
8 years ago
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The main reason is probably because the kidneys never get the signal to convert
calcidiol
to calcitriol, & PCa tends to suppress the conversion that naturally occurs in prostate cells.
The main reason is probably because the kidneys never get the signal to convert
calcidiol
to calcitriol, & PCa tends to suppress the conversion that naturally occurs in prostate cells.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Blood Result
Hi Apologies for the long long post I have Diabetes type 2, Thyroidectomy, B12 deficiency, Calcium Deficiency. I constantly feel unwell with foggy brain, aches and pains and fatigue. Everything is always blamed on high blood sugars. They never seem to look past me being a diabetic which is frustrating
Hi Apologies for the long long post I have Diabetes type 2, Thyroidectomy, B12 deficiency, Calcium Deficiency. I constantly feel unwell with foggy brain, aches and pains and fatigue. Everything is always blamed on high blood sugars. They never seem to look past me being a diabetic which is frustrating
jobey30
in
Thyroid UK
8 years ago
Vitamin D
" {1,25-D (calcitriol) is the active hormonal form of D, whereas 25-D (aka
calcidiol
& 25(OH)D)) is the inactive form of D used in blood tests.}
" {1,25-D (calcitriol) is the active hormonal form of D, whereas 25-D (aka
calcidiol
& 25(OH)D)) is the inactive form of D used in blood tests.}
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Vitamin D & J-/U-Shaped PCa Risk
Calcidiol
is converted to calcitriol only as needed. Sure, the production of calcitriol triggers production of the enzyme that will ultimately clear it from the cell. But having more
calcidiol
outside does not mean that prostate cells will make more calcitriol inside.
Calcidiol
is converted to calcitriol only as needed. Sure, the production of calcitriol triggers production of the enzyme that will ultimately clear it from the cell. But having more
calcidiol
outside does not mean that prostate cells will make more calcitriol inside.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Vitamin D & Mortality
Big surprise - deficiency is not a good place to be, after all: "In this study population, {
calcidiol
} was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high {
calcidiol
} was associated with increased risk of prostate cancer."
Big surprise - deficiency is not a good place to be, after all: "In this study population, {
calcidiol
} was inversely associated with total mortality during more than two decades of follow-up, despite, as previous reported, high {
calcidiol
} was associated with increased risk of prostate cancer."
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Generally unwell - need advise
Hi First time posting and apologies for the long post but I don't know what to ask for at the GP's they seem to fob me off all the time saying its due to diabetes but I don't think it is. I am also under a endocrinologist but he doesn't seem to think outside the box and wont discuss Diabetes says he
Hi First time posting and apologies for the long post but I don't know what to ask for at the GP's they seem to fob me off all the time saying its due to diabetes but I don't think it is. I am also under a endocrinologist but he doesn't seem to think outside the box and wont discuss Diabetes says he
jobey30
in
Thyroid UK
9 years ago
Research shows that T3/T4 combo stops working after 3-4 months says Endo
Just had an appointment with my Endo and I basically told her I was self medicating with T3 added to my T4 as I'm not converting T4 into T3. She then said that many research studies carried out by the British Thyroid Foundation have shown that the T4/T3 combo works for about 3-4 months for patients
Just had an appointment with my Endo and I basically told her I was self medicating with T3 added to my T4 as I'm not converting T4 into T3. She then said that many research studies carried out by the British Thyroid Foundation have shown that the T4/T3 combo works for about 3-4 months for patients
mischa
in
Thyroid UK
9 years ago
Thyroid Med update
I would welcome any further thoughts on my ongoing thyroid saga! After TT last Feb & on going issues with Calcium, very high TSH and T4, some of you will recall I consulted a private Endo four weeks ago. I am diagnosed with Hypoparathyroidism. I was in 150 Levo and had 10mg T3 added by Endo which I
I would welcome any further thoughts on my ongoing thyroid saga! After TT last Feb & on going issues with Calcium, very high TSH and T4, some of you will recall I consulted a private Endo four weeks ago. I am diagnosed with Hypoparathyroidism. I was in 150 Levo and had 10mg T3 added by Endo which I
Flowerpower_nafas
in
Thyroid UK
10 years ago
Introducing T3
Following my successful appointment with a private Endo last week, I just wanted to update everyone on my progress. I received a three page report from my Endo full of recommendations to my GP and went off on Monday morning to consult the Senior Partner in the Practice. The Endo stated I had multiple
Following my successful appointment with a private Endo last week, I just wanted to update everyone on my progress. I received a three page report from my Endo full of recommendations to my GP and went off on Monday morning to consult the Senior Partner in the Practice. The Endo stated I had multiple
Flowerpower_nafas
in
Thyroid UK
10 years ago
Has anyone one on the site got genetic HYPOPARATHYROIDISM ?
Hi, I am a lady with an underactive thyroid but also suffering with Hypoparathyroidism. It is genetic in our case not surgery related, my son is also a sufferer. I take calcitriol but am now worried I have liver damage due to my medication. I would love to talk to someone else with the same as I.
Hi, I am a lady with an underactive thyroid but also suffering with Hypoparathyroidism. It is genetic in our case not surgery related, my son is also a sufferer. I take calcitriol but am now worried I have liver damage due to my medication. I would love to talk to someone else with the same as I.
Jillymo
in
Thyroid UK
11 years ago
Safe Upper Limit of Vitamin D Identified for First Time from Medscape
For example, in subjects with serum
calcidiol
levels of 20 ng/mL, supplementation of 30 µg (1200 IU) per day might suffice to attain serum
calcidiol
of 32 ng/mL, "while those whose blood level is 30 ng/mL may require only 5 µg (200 IU) per day, which would raise their serum
calcidiol
to a level of 32
For example, in subjects with serum
calcidiol
levels of 20 ng/mL, supplementation of 30 µg (1200 IU) per day might suffice to attain serum
calcidiol
of 32 ng/mL, "while those whose blood level is 30 ng/mL may require only 5 µg (200 IU) per day, which would raise their serum
calcidiol
to a level of 32
NBob
in
Thyroid UK
11 years ago
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