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Cabazitaxel
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Jevtana [Cabazitaxel] & Androgen Status.
We confirmed that
cabazitaxel
pharmacokinetics were not affected by testosterone, suggesting that androgen status might influence
cabazitaxel
tumor uptake directly.
We confirmed that
cabazitaxel
pharmacokinetics were not affected by testosterone, suggesting that androgen status might influence
cabazitaxel
tumor uptake directly.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
The study enrolled 50 patients who were no longer responding to standard treatments, including docetaxel (Taxotere), abiraterone acetate (Zytiga), enzalutamide (Xtandi), or
cabazitaxel
(Jevtana). Genomic sequencing was performed on tumor biopsies as a requirement of the study.
The study enrolled 50 patients who were no longer responding to standard treatments, including docetaxel (Taxotere), abiraterone acetate (Zytiga), enzalutamide (Xtandi), or
cabazitaxel
(Jevtana). Genomic sequencing was performed on tumor biopsies as a requirement of the study.
JLS1
in
Advanced Prostate Cancer
7 years ago
Has anyone had Jevtana (cabazitaxel) + carboplatin
Starting Jevtana (
cabazitaxel
) + carboplatin chemo next week and wondering if anyone here has any words of wisdom?
Starting Jevtana (
cabazitaxel
) + carboplatin chemo next week and wondering if anyone here has any words of wisdom?
JLS1
in
Advanced Prostate Cancer
7 years ago
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Anyone with similar experience?
Then treated with taxotere with prednisone and xgeva injections then treated with
cabazitaxel
and finally xtandi while still getting xgeva injections monthly. The xtandi seemed to be working well - brought his PSA down to .80 but suddenly he had difficulty walking.
Then treated with taxotere with prednisone and xgeva injections then treated with
cabazitaxel
and finally xtandi while still getting xgeva injections monthly. The xtandi seemed to be working well - brought his PSA down to .80 but suddenly he had difficulty walking.
GTWaites
in
Advanced Prostate Cancer
7 years ago
Back to Chemo
First time around was with taxotere, second with carboplatin and etoposide and this time
cabazitaxel
. Feel like we are almost out of options as if this fails, the last thing we have available is possibly a clinical trial. Spirits are down for both of us but I am trying to stay positive.
First time around was with taxotere, second with carboplatin and etoposide and this time
cabazitaxel
. Feel like we are almost out of options as if this fails, the last thing we have available is possibly a clinical trial. Spirits are down for both of us but I am trying to stay positive.
sweetudog
in
Advanced Prostate Cancer
7 years ago
Xtandi (Enzalutamide) & Drug-Drug Interaction.
Enzalutamide (160 mg QD) was administered concomitantly after the first
cabazitaxel
cycle, during 6 weeks. Primary endpoint was the difference in mean area under the curve (AUC) between the first (
cabazitaxel
monotherapy) and third
cabazitaxel
cycle, when enzalutamide was added.
Enzalutamide (160 mg QD) was administered concomitantly after the first
cabazitaxel
cycle, during 6 weeks. Primary endpoint was the difference in mean area under the curve (AUC) between the first (
cabazitaxel
monotherapy) and third
cabazitaxel
cycle, when enzalutamide was added.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
my journey
Have had radiation, tried zolodex then 20 treatments docetaxel then 68 treatments
cabazitaxel
chemo ended 1yr ago.numerous viscious side effects. currently on elligard and denosumab feeling great, little tired on elligard.
Have had radiation, tried zolodex then 20 treatments docetaxel then 68 treatments
cabazitaxel
chemo ended 1yr ago.numerous viscious side effects. currently on elligard and denosumab feeling great, little tired on elligard.
Izab
in
Advanced Prostate Cancer
7 years ago
Cabazitaxel, Abiraterone or Enzalutamide?
I have been given 3 options which are
Cabazitaxel
, Abiraterone or Enzalutamide!
I have been given 3 options which are
Cabazitaxel
, Abiraterone or Enzalutamide!
andysb
in
Advanced Prostate Cancer
7 years ago
Xofigo Timing.
In the phase 3 TROPIC study, treatment with
cabazitaxel
was associated with significant myelosuppression (all grades neutropenia [94%], leukopenia [96%], anemia [97%], and thrombocytopenia [47%]) with relatively high rates of febrile neutropenia (8%).
In the phase 3 TROPIC study, treatment with
cabazitaxel
was associated with significant myelosuppression (all grades neutropenia [94%], leukopenia [96%], anemia [97%], and thrombocytopenia [47%]) with relatively high rates of febrile neutropenia (8%).
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Testing for BRCA Mutations.
He works in the clinical drug development Phase I trials program at the Royal Marsden NHS Foundation Trust Hospital, and he has been involved in the early clinical development of more than 100 novel agents—many of which are now approved drugs, including abiraterone, MDV3100 and
cabazitaxel
for advanced
He works in the clinical drug development Phase I trials program at the Royal Marsden NHS Foundation Trust Hospital, and he has been involved in the early clinical development of more than 100 novel agents—many of which are now approved drugs, including abiraterone, MDV3100 and
cabazitaxel
for advanced
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Where to go next for clinical trials? Sloan or Dana Farber
I am on my 7th treatment of 10 with
cabazitaxel
with advanced pc and trying to figure out what the next game plan is (I've tried all treatments out there; zytega, doc,
cabazitaxel
, radium) I'm centrally located to both as I live in Albany ny.
I am on my 7th treatment of 10 with
cabazitaxel
with advanced pc and trying to figure out what the next game plan is (I've tried all treatments out there; zytega, doc,
cabazitaxel
, radium) I'm centrally located to both as I live in Albany ny.
SaratogaNYAnthony
in
Advanced Prostate Cancer
7 years ago
Failed all gold standard treatments and both Chemos? Whats next?
Have failed all gold standard treatments, Lupron, casodex, Zytiga, Xtandi, Taxotere,
cabazitaxel
, etc. was about to start Xofigo but then was refused due to mets on the liver. My PSA is 600 now.
Have failed all gold standard treatments, Lupron, casodex, Zytiga, Xtandi, Taxotere,
cabazitaxel
, etc. was about to start Xofigo but then was refused due to mets on the liver. My PSA is 600 now.
sinjonn
in
Advanced Prostate Cancer
7 years ago
FIRSTANA Trial - Cabazitaxel 20/25 mg v. Docetaxel 75 mg
> "Men receiving
cabazitaxel
were more likely to experience febrile neutropenia, neutropenic infection, diarrhea, and hematuria than those who received docetaxel."
> "Men receiving
cabazitaxel
were more likely to experience febrile neutropenia, neutropenic infection, diarrhea, and hematuria than those who received docetaxel."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Jevtana Results
I started my chemo treatment with Jevtana (
Cabazitaxel
) after Taxotere was not able to contain the lymph nodes tumor growth around my bladder or lower my PSA and I was wondering if other guys have gone this route and what were the results. I have already gone through Xtandi, Zytiga etc....
I started my chemo treatment with Jevtana (
Cabazitaxel
) after Taxotere was not able to contain the lymph nodes tumor growth around my bladder or lower my PSA and I was wondering if other guys have gone this route and what were the results. I have already gone through Xtandi, Zytiga etc....
LP16
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
"A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate, enzalutamide, cabozantinib, carboplatin or
cabazitaxel
."
"A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate, enzalutamide, cabozantinib, carboplatin or
cabazitaxel
."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Fail Docetaxel ?..No Problem..Cabazitaxel Still Works
https://www.ncbi.nlm.nih.gov/pubmed/28718092 Gus
https://www.ncbi.nlm.nih.gov/pubmed/28718092 Gus
gusgold
in
Advanced Prostate Cancer
7 years ago
No Appetite, Cant Eat, Nauseas
chemo med Jevtana /
cabazitaxel
, had terrible time, constipated (failed to take enough laxative) Blood in Urine problem, etc.... palliative said he could give me a pill (remeron) anti depressant, for nausea /stomach ache , that should make me want to eat.
chemo med Jevtana /
cabazitaxel
, had terrible time, constipated (failed to take enough laxative) Blood in Urine problem, etc.... palliative said he could give me a pill (remeron) anti depressant, for nausea /stomach ache , that should make me want to eat.
MrJack
in
Advanced Prostate Cancer
7 years ago
Effective supplements?
After
cabazitaxel
remain xtandi and/or zytiga. I’ve een told that immunotherapy isn’t an option for prostate cancer, yet. I’m always looking for something to add to standard therapies.
After
cabazitaxel
remain xtandi and/or zytiga. I’ve een told that immunotherapy isn’t an option for prostate cancer, yet. I’m always looking for something to add to standard therapies.
enzo1
in
Advanced Prostate Cancer
7 years ago
STAMPEDE - Zytiga at ADT initiation. NEJM Paper.
Several agents have improved overall survival (docetaxel, abiraterone acetate, enzalutamide,
cabazitaxel
, radium-223, and sipuleucel-T)1-8 or reduced morbidity (zoledronic acid and denosumab)9-11 among such patients.
Several agents have improved overall survival (docetaxel, abiraterone acetate, enzalutamide,
cabazitaxel
, radium-223, and sipuleucel-T)1-8 or reduced morbidity (zoledronic acid and denosumab)9-11 among such patients.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Jevtana / Cabazitaxel
I am on my second cycle now with Jevtana /
Cabazitaxel
, I take a dose every three weeks my PSA has just gone down from 21 to 6, so Jevtana is working, I hope it works a long time I only got about seven months of play out of Taxotere , my Onc, says this in the last chemo drug we have to try then it is
I am on my second cycle now with Jevtana /
Cabazitaxel
, I take a dose every three weeks my PSA has just gone down from 21 to 6, so Jevtana is working, I hope it works a long time I only got about seven months of play out of Taxotere , my Onc, says this in the last chemo drug we have to try then it is
MrJack
in
Advanced Prostate Cancer
7 years ago
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