Average Life Expectancy After Doublet Therapy Fails

[Skilover]

Hi- I try to enjoy my life and not worry too much about what the future may hold nor how long a future I may have- but today I felt the desire to inquire. I have been very fortunate in my response to doublet treatment therapy since my Dx almost 13 years ago (triplet therapy was not the SOC back then, and I never advanced beyond doublet treatment). I haven't failed doublet therapy yet, but with PSA rises needing to be reduced with "whack-a-mole" radiation on at 2 occasions in the last 2-3 yrs, it appears to me that I may end up becoming castrate resistant "sooner rather than later" Does anyone have any information on how long "whack-a-mole" can help in keeping PSA at undetectable or very low levels- OR, does anyone have any info regarding average life expectancies "these days" (with all the additional treatments we now have as compared to 13 yrs ago)? Are there patients who have lived 5 yrs or more following the failure of doublet therapy? I will thank those who respond IN ADVANCE to avoid everyone receiving numerous "thank yous".

[GoBucks]

"I try to enjoy my life & not worry too much...." You need to focus on that. Don't go down the rabbit hole. What if I told you you're a goner in March 2030? April 2029? August 2033? Feel better? I didn't know my expiration date before diagnosis and I still don't. I presume it is less than someone without Stage 4 but who knows? I'm 71 & life expectancy in the U.S. is 85. My Dad had many ailments and lived to 102. Mom died at 61. L'chaim!!

[Skilover in reply to GoBucks]

GoBucks- I tend to be a very fact oriented, logical person who prefers information over ignorance and would like to get a sense of the "average" life expectancy following failure of doublet therapy I have responded very well to treatment thus far and would remain cautiously optimistic that I would do so again when a change in treatments(s) is needed. I tend not to be an "ignorance is bliss" kinda guy. I appreciate your post, but wouldn't have made mine if I didn't want the info requested. Thx and good luck.

[GoBucks in reply to Skilover]

I replied because no one else was. My whole point was that no one knows how long we have have, cancer or no cancer. Hope Stephanie gave you what you were seeking.

[j-o-h-n]

Note: If married, life expectancy is considerably shorter.

Good Luck, Good Health and Good Humor.

j-o-h-n

[GoBucks in reply to j-o-h-n]

Lucky for us that's why you're still with us!

[j-o-h-n in reply to GoBucks]

Barely.....

Good Luck, Good Health and Good Humor.

j-o-h-n

[BILIE in reply to j-o-h-n]

THANKS for a REALLY GOOD CHUCKLE this AM j-o-h-n !!

[j-o-h-n in reply to BILIE]

You're welcome....(BTW my wife just smacked me) .

Good Luck, Good Health and Good Humor.

j-o-h-n

[mangeycritter in reply to j-o-h-n]

Your comment reminded me of an (sexist) joke:

Do you know why men die before their wives?

They want to.

[j-o-h-n in reply to mangeycritter]

Not only do we want to.... we plan to.........

Good Luck, Good Health and Good Humor.

j-o-h-n

[JohnInTheMiddle in reply to j-o-h-n]

I appreciate always your humor j-o-h-n, and you probably already know this but just for the record, beyond the laughs, if married and especially for men, life expectancy is significantly longer 😃

[j-o-h-n in reply to JohnInTheMiddle]

It just seems so............

Good Luck, Good Health and Good Humor.

j-o-h-n

[103532]

These are my thoughts on this. If/when numbers rise to a scannable level, I would wack a mole if safe and try to extend the efficacy of the doublet with switching steroids if on Abi. If that fails, try Xtandi. I figure that could slow progression to around 6 mos. Following that, I would try for Pluvicto (with ADT) before chemo if PSMA avid, which I estimate could hold progression for a year. If Pluvico fails, then I would seek chemo with ADT (again), which I think could hold progression for another six months. If that failed, then I would try for a second round or start immunotherapy, which I estimate could hold for another six months. If that fails, then there is Jetvana and personalized novel therapies which I would hope could slow progression for another six months. All the while I would radiate if safe and keep my bones as strong as possible. To sum it up, I think there enough tools in the kit to keep a person in treatment for at least three plus years before the Mets really take hold and, at this rate, there will be much more available by then which would likely bring treatment options up to even five years duration or more after MCRPC. Hoping and praying the clinical trials are working in our favor.

Stephanie