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23 public posts

Besremi trial

Two New Trials Testing Ropeginterferon (Besremi) in PV and ETMar 3, 2023John Mascarenhas, MDAssociate Professor & Director of the Adult Leukemia Program0 seconds of 8 minutes, 40 secondsDESCRIPTIONTRANSCRIPTDr. Mascarenhas: Hi, I'm John Mascarenhas, a professor of medicine at the Icahn School of Medicine
Two New Trials Testing Ropeginterferon (Besremi) in PV and ETMar 3, 2023John Mascarenhas, MDAssociate Professor & Director of the Adult Leukemia Program0 seconds of 8 minutes, 40 secondsDESCRIPTIONTRANSCRIPTDr. Mascarenhas: Hi, I'm John Mascarenhas, a professor of medicine at the Icahn School of Medicine
wateron profile image
wateron
in MPN Voice
3 months ago

Real world experience with Besremi in ET and PV following exposure to Pegasys.

Abstract Despite widespread use of Pegylated forms of Inteferon in the management of Myeloproliferative Neoplasms (MPN), most clinicians have experience predominantly with peginterferon alfa-2a (Pegasys). Third generation pegylated IFNα, ropeginterferon alfa-2b (ropegIFN; Besremi), was recommended
Abstract Despite widespread use of Pegylated forms of Inteferon in the management of Myeloproliferative Neoplasms (MPN), most clinicians have experience predominantly with peginterferon alfa-2a (Pegasys). Third generation pegylated IFNα, ropeginterferon alfa-2b (ropegIFN; Besremi), was recommended
Manouche profile image
Manouche
in MPN Voice
5 months ago

Christmas Chuckle

Holiday time is for feasting; We look forward to each treat. The tables are full of our favorite foods; We’ve got lots of good things to eat. We scarf marshmallowed sweet potatoes; There’s cider and eggnog to slurp. There’s so much going down at once, Who can help an occasional burp? Here’
Holiday time is for feasting; We look forward to each treat. The tables are full of our favorite foods; We’ve got lots of good things to eat. We scarf marshmallowed sweet potatoes; There’s cider and eggnog to slurp. There’s so much going down at once, Who can help an occasional burp? Here’
Paul_and_Sue_Wood profile image
Paul_and_Sue_Wood
in Multiple System Atrophy Trust
5 months ago
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Keeping Interferon refrigerated

Hi, I've recently started taking Peginterferon alfa-2a, and I keep it in my fridge because that's what the instructions say. I'm going to visit my girlfriend in Scotland a week tomorrow. My journey is going to take two days, so I'll leave home on Saturday morning, stay in a hotel halfway on Saturday
Hi, I've recently started taking Peginterferon alfa-2a, and I keep it in my fridge because that's what the instructions say. I'm going to visit my girlfriend in Scotland a week tomorrow. My journey is going to take two days, so I'll leave home on Saturday morning, stay in a hotel halfway on Saturday
little_oblivion profile image
little_oblivion
in MPN Voice
8 months ago

Interferons as the First Choice of Cytoreduction in ET and PV

 »Interferons are a group of cytokines with immunomodulatory properties and were the first immune therapies used in the treatment of cancers, including hematologic malignancies. Use of standard interferon alfa-2b for MPN treatment has been limited by its difficulty in administration and adverse effect
 »Interferons are a group of cytokines with immunomodulatory properties and were the first immune therapies used in the treatment of cancers, including hematologic malignancies. Use of standard interferon alfa-2b for MPN treatment has been limited by its difficulty in administration and adverse effect
Manouche profile image
Manouche
in MPN Voice
9 months ago

Cost of Interferon Alfa 2a

Does Interferon Alfa 2a (Pegasus) cost $1000 for 180mcg/ml ?? Without insurance?
Does Interferon Alfa 2a (Pegasus) cost $1000 for 180mcg/ml ?? Without insurance?
MrThara profile image
MrThara
in MPN Voice
1 year ago

Peg injections - two in one day

Hi all, I’m on peginterferon Alfa-2a for ET and a few weeks ago my dose was increased to 180mg. The hospital pharmacy deliver my medication and I can only assume they’ve ran out of 180mg syringes as I’ve been sent about 8 boxes of 90mg pre filled syringes meaning I’m expected to do 2 injections after
Hi all, I’m on peginterferon Alfa-2a for ET and a few weeks ago my dose was increased to 180mg. The hospital pharmacy deliver my medication and I can only assume they’ve ran out of 180mg syringes as I’ve been sent about 8 boxes of 90mg pre filled syringes meaning I’m expected to do 2 injections after
FashionLover profile image
FashionLover
in MPN Voice
1 year ago

Greater Understanding of PV, ET Drives Potential New Treatment Options

“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
Manouche profile image
Manouche
in MPN Voice
2 years ago

Roxadustat and thyroid-stimulating hormone suppression

Just posting this so that it has been posted. I have my doubts it will be relevant to more than a handful - but I could be wrong. [i]Roxadustat and thyroid-stimulating hormone suppression Atsuyuki Tokuyama, Hiroyuki Kadoya, Atsushi Obata, Takahiro Obata, Tamaki Sasaki, Naoki Kashihara Clinical
Just posting this so that it has been posted. I have my doubts it will be relevant to more than a handful - but I could be wrong. [i]Roxadustat and thyroid-stimulating hormone suppression Atsuyuki Tokuyama, Hiroyuki Kadoya, Atsushi Obata, Takahiro Obata, Tamaki Sasaki, Naoki Kashihara Clinical
helvella profile image
helvella
Thyroid UKin Thyroid UK
2 years ago

On bone marrow biopsy (BMB)?

Hello everyone, People with PV/ET regularly (e.g., per month) test their blood to keep track of cell counts and other things. How about bone marrow biopsy (BMB)? Are there repeats of BMB test to check changes after the first one that was performed to detect any mutation like JK2 ? If yes, how the results
Hello everyone, People with PV/ET regularly (e.g., per month) test their blood to keep track of cell counts and other things. How about bone marrow biopsy (BMB)? Are there repeats of BMB test to check changes after the first one that was performed to detect any mutation like JK2 ? If yes, how the results
samiris profile image
samiris
in MPN Voice
3 years ago

Dukoral - Cholera Vaccine

I just took my first dose of Dukoral. I will wait a week to take the second dose. A friend of mine who lives outside of Detroit Michigan went over to Windsor and made the purchase and had no problem crossing the border with it. He declared it as an over the counter diarrhea med. The agent laughed
I just took my first dose of Dukoral. I will wait a week to take the second dose. A friend of mine who lives outside of Detroit Michigan went over to Windsor and made the purchase and had no problem crossing the border with it. He declared it as an over the counter diarrhea med. The agent laughed
Drphil1938 profile image
Drphil1938
in Advanced Prostate Cancer
4 years ago

Pipeline of ataxia related research.

Found a report online being offered for $2000 that summarizes the current pipeline of all known ataxia related drugs. - - - Spinocerebellar Ataxia (SCA) - Companies Involved in Therapeutics Development Bio Blast Pharma Ltd Biohaven Pharmaceutical Holding Company Ltd Cadent Therapeutics Ionis Pharmaceuticals
Found a report online being offered for $2000 that summarizes the current pipeline of all known ataxia related drugs. - - - Spinocerebellar Ataxia (SCA) - Companies Involved in Therapeutics Development Bio Blast Pharma Ltd Biohaven Pharmaceutical Holding Company Ltd Cadent Therapeutics Ionis Pharmaceuticals
sunvox profile image
sunvox
in Ataxia UK
5 years ago

Knight five

Myself and a wee Baroness posing with Sir Alka Seltzer Cheesemonger This particular knight was a thrice married man who once went into battle wearing nothing but a smile. He stoutly refused to use a sword and when that tactic finally caught up with him, his replacement was severed. Forever more he was
Myself and a wee Baroness posing with Sir Alka Seltzer Cheesemonger This particular knight was a thrice married man who once went into battle wearing nothing but a smile. He stoutly refused to use a sword and when that tactic finally caught up with him, his replacement was severed. Forever more he was
BaronC profile image
BaronC
in Headway
6 years ago

Bloated constipation due to ibs

So I've had ibs for a year and have found its triggered by pork and stress. I've cut out the pork apart from the odd accident but stress is a different matter. I recently flew to majorca . The stress caused diarrhoea so took an imodium and u haven't on since. The pain is excruciating but u don't want
So I've had ibs for a year and have found its triggered by pork and stress. I've cut out the pork apart from the odd accident but stress is a different matter. I recently flew to majorca . The stress caused diarrhoea so took an imodium and u haven't on since. The pain is excruciating but u don't want
Deb131 profile image
Deb131
in IBS Network
6 years ago

Air bubbles in chest, pain, shortness of breath

I get this feeling maybe 2-3 times a year, it starts off as very mild in lower left chest then moved up the middle of my chest and the pain becomes intense. To the point where I am curled up on the floor trying to find a position it will stop, sweating perfusuly. I seen a lot of people on here with the
I get this feeling maybe 2-3 times a year, it starts off as very mild in lower left chest then moved up the middle of my chest and the pain becomes intense. To the point where I am curled up on the floor trying to find a position it will stop, sweating perfusuly. I seen a lot of people on here with the
Disclosure profile image
Disclosure
in Anxiety Support
6 years ago

Only you will get how exciting this is...

Ok, so we are taking our 7 year old away for the night to stay near a hotel near Longleat for a half term treat (in a vague attempt to beat the crowds in the morning). I take the usual deep breath (as am aware that eating out 9 times out of 10 has resulted in some unwanted symptoms reappearing). Plans
Ok, so we are taking our 7 year old away for the night to stay near a hotel near Longleat for a half term treat (in a vague attempt to beat the crowds in the morning). I take the usual deep breath (as am aware that eating out 9 times out of 10 has resulted in some unwanted symptoms reappearing). Plans
Hidden profile image
Hidden
in Gluten Free Guerrillas
6 years ago

What is your OTC Painkiller of choice for Migraine (UK)?

As we know, for some of us nothing really works to take away the pain - after years of trial and error with meds. Been through the spectrum of painkillers. By far I find the most effective to be Alka Seltzer, the effect of the aspirin and effervescence does offer *some* relief. That is, only if it's
As we know, for some of us nothing really works to take away the pain - after years of trial and error with meds. Been through the spectrum of painkillers. By far I find the most effective to be Alka Seltzer, the effect of the aspirin and effervescence does offer *some* relief. That is, only if it's
Moon_Struck profile image
Moon_Struck
in National Migraine Centre
7 years ago

Viread, peginterferon alfa-2a more effective in combination for reducing HBsAg

http://www.healio.com/hepatology/chronic-hepatitis/news/online/%7B625d1cdc-2b04-42c8-9e2f-9e73931fc5c6%7D/viread-peginterferon-alfa-2a-more-effective-in-combination-for-reducing-hbsag?utm_source=maestro&utm_medium=email&utm_campaign=hepatology%20news
http://www.healio.com/hepatology/chronic-hepatitis/news/online/%7B625d1cdc-2b04-42c8-9e2f-9e73931fc5c6%7D/viread-peginterferon-alfa-2a-more-effective-in-combination-for-reducing-hbsag?utm_source=maestro&utm_medium=email&utm_campaign=hepatology%20news
kcohen profile image
kcohen
in HFI Connect - Hepatitis
8 years ago

Interferon monotherapy effective in patients with HCV thalassemia major

Interferon alfa-2b or pegylated interferon-alfa-2b monotherapies were effective treatment options in patients with hepatitis C virus thalassemia major, according to study results. “IL28B genotype was a strong predictor for sustained virological response, together with splenectomy, age and fibrosis,”
Interferon alfa-2b or pegylated interferon-alfa-2b monotherapies were effective treatment options in patients with hepatitis C virus thalassemia major, according to study results. “IL28B genotype was a strong predictor for sustained virological response, together with splenectomy, age and fibrosis,”
kcohen profile image
kcohen
in HFI Connect - Hepatitis
8 years ago

Does Pegylated interferon alfa-2a cure ET? Some paper show yes. Is this credible?

I found a paper Quintás-Cardama A, Kantarjian H, Manshouri T, et al. Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera[J]. Journal of Clinical Oncology, 2009, 27(32): 5418-5424. This show the
I found a paper Quintás-Cardama A, Kantarjian H, Manshouri T, et al. Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera[J]. Journal of Clinical Oncology, 2009, 27(32): 5418-5424. This show the
Midas_ profile image
Midas_
in MPN Voice
8 years ago
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