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Scientists discover novel oncogenic driver gene in human lung cancer
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
2greys
in
Lung Conditions Community Forum
3 years ago
Transplant at age 68 or not
I've had myelofibrosis for about 30 years and been on ruxolitinib successfully for about 8 years. We have just moved to Scotland and my new consultant has laid it on the line that rux doesn't go on working for ever and my only other option is transplant. This seems right to me but I am very nervous about
I've had myelofibrosis for about 30 years and been on ruxolitinib successfully for about 8 years. We have just moved to Scotland and my new consultant has laid it on the line that rux doesn't go on working for ever and my only other option is transplant. This seems right to me but I am very nervous about
Bullace
in
MPN Voice
3 years ago
Nutrition and Cll
I was diagnosed with Cll 3 months ago but my GP doctor suspected it a year ago. I am on W&W. I am wondering if I need to be on any kind of special diet and what supplements to take or not to take? The hematologist asked for a list of prescriptions and supplements I take but did not comment on them.
I was diagnosed with Cll 3 months ago but my GP doctor suspected it a year ago. I am on W&W. I am wondering if I need to be on any kind of special diet and what supplements to take or not to take? The hematologist asked for a list of prescriptions and supplements I take but did not comment on them.
sugar03
in
CLL Support
3 years ago
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MBL is now CLL
Hi all, My MBL has progressed to CLL stage 1 after 8 years which I am struggling to come to terms with. I am now 51. Small glands in neck and groin and possibly a slightly enlarged spleen my lymphocytes were around 12-14 For couple of years but shot up to 24 recently. I am getting scams in 3 months.
Hi all, My MBL has progressed to CLL stage 1 after 8 years which I am struggling to come to terms with. I am now 51. Small glands in neck and groin and possibly a slightly enlarged spleen my lymphocytes were around 12-14 For couple of years but shot up to 24 recently. I am getting scams in 3 months.
Billy_Oz
in
CLL Support
3 years ago
8 months
So after 8 months on Ibrutinib my spleen is close to normal size, my blood count is normal, but 1/4 to 1/3 of my lymphocytes are still CLL. Side effects are gone, although I do get the odd day with stiff joints. Great progress, and my life is almost normal again. I didn’t respond to the Covid vaccines
So after 8 months on Ibrutinib my spleen is close to normal size, my blood count is normal, but 1/4 to 1/3 of my lymphocytes are still CLL. Side effects are gone, although I do get the odd day with stiff joints. Great progress, and my life is almost normal again. I didn’t respond to the Covid vaccines
809123
in
CLL Support
3 years ago
Relapsing on Ibrutinib
Hello everyone, as I mention here a few weeks ago, my treatment with Ibrutinib is going to end soon due to (Dr. thinks) a mutation. I am going to see the Oncologist in 2 weeks and I have to make a decision which treatment I want to be put on. There are two options open for me. One is Venetoclax and
Hello everyone, as I mention here a few weeks ago, my treatment with Ibrutinib is going to end soon due to (Dr. thinks) a mutation. I am going to see the Oncologist in 2 weeks and I have to make a decision which treatment I want to be put on. There are two options open for me. One is Venetoclax and
Doremefasol
in
CLL Support
3 years ago
Greater Understanding of PV, ET Drives Potential New Treatment Options
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said. Researchers are also determining how to best optimize current treatment options, including JAK inhibitors
Manouche
in
MPN Voice
3 years ago
From the CLL14 Study: Venetoclax Plus Obinutuzumab Prolongs Progression Free Survival, Not Overall Survival , in CLL
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
These results, from the CLL14 study (ClinicalTrials.gov Identifier: NCT02242942), were presented at the European Hematology Association (EHA) 2021 Virtual Congress. Extended follow-up suggests that venetoclax plus obinutuzumab prolongs progression-free survival (PFS), but not overall survival (OS), when
Jm954
Administrator
in
CLL Support
3 years ago
STELLAR Trial in the UK for Richter's
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Just a reminder that there is a UK trial at 17 centres around the UK for patients who have a Richter's transformation of their CLL. The usual treatment for Richter’s syndrome is R-CHOP. This is a combination of chemotherapy drugs and a targeted drug called rituximab. This treatment can help and cure
Jm954
Administrator
in
CLL Support
3 years ago
I have had both doses of the Pfizer vaccine, while they applauded me after I got my 2nd dose, 90 days later I found that I have no immunity!
I took Ibrutinib prior to January 20 when it gave me AFib and a few other problems, then stated Venetoclax in July of 2020, and in August started the first of six doses of Rituxan. It would seem that Rituxan is the main culprit, as in my research I found that no immunity was created in cases which
I took Ibrutinib prior to January 20 when it gave me AFib and a few other problems, then stated Venetoclax in July of 2020, and in August started the first of six doses of Rituxan. It would seem that Rituxan is the main culprit, as in my research I found that no immunity was created in cases which
KevinCLLITP
in
CLL Support
3 years ago
Ruxolitinib discontinuation in polycythemia vera:
« After discontinuation, only 4 patients (18 %) received subsequent cytoreductive therapy, including hydroxyurea in one patient and pegylated interferon α-2a in three patients »… « discontinuation of ruxolitinib in PV was associated with generally favorable outcomes. However, there is a lack of available
« After discontinuation, only 4 patients (18 %) received subsequent cytoreductive therapy, including hydroxyurea in one patient and pegylated interferon α-2a in three patients »… « discontinuation of ruxolitinib in PV was associated with generally favorable outcomes. However, there is a lack of available
Manouche
in
MPN Voice
3 years ago
BTK inhibitors for the treatment of CLL - the current state of play of 'brutinibs'
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
CLLerinOz
Administrator
in
CLL Support
3 years ago
mpal leukaemia
Hi Would really love to hear from anyone who has experience with this rare type of leukaemia. My son was diagnosed in December 2020 and is about to undergo a bone marrow transplant
Hi Would really love to hear from anyone who has experience with this rare type of leukaemia. My son was diagnosed in December 2020 and is about to undergo a bone marrow transplant
su0906
in
Leukaemia Support
3 years ago
“I think we’ll cure leukemia in my lifetime”
“Is there anything else you’d like to share about leukemia treatment? I'm very excited because I think we’ll cure leukemia in my lifetime. We’ve already come so far. For example, before 2000, patients with Philadelphia chromosome-positive acute lymphoblastic leukemia had a survival rate of 10%. Targeted
“Is there anything else you’d like to share about leukemia treatment? I'm very excited because I think we’ll cure leukemia in my lifetime. We’ve already come so far. For example, before 2000, patients with Philadelphia chromosome-positive acute lymphoblastic leukemia had a survival rate of 10%. Targeted
Manouche
in
MPN Voice
3 years ago
RUXOLITINIB
Two weeks ago I was lucky enough to be accepted for the drug Ruxolitinib. Previously I was on Hydroxycarbamide which my body rejected and caused breathing problems. All went well for the first week on Ruxotilib but 4 days ago I started feeling very unwell lightheadedness, nauseous, bloating all the side
Two weeks ago I was lucky enough to be accepted for the drug Ruxolitinib. Previously I was on Hydroxycarbamide which my body rejected and caused breathing problems. All went well for the first week on Ruxotilib but 4 days ago I started feeling very unwell lightheadedness, nauseous, bloating all the side
Heather270240
in
MPN Voice
3 years ago
Hairy cell - 3 weeks after chemo
So here I am 3 weeks after my cladribine subcutaneous chemo finished. Am having weekly blood tests, had a phone chat with my haematologist this morning who is happy the way my platelets and neutrophiles are recovering - plats up to 138 and neuts 0.6, both doubled from a week ago. The main problem is
So here I am 3 weeks after my cladribine subcutaneous chemo finished. Am having weekly blood tests, had a phone chat with my haematologist this morning who is happy the way my platelets and neutrophiles are recovering - plats up to 138 and neuts 0.6, both doubled from a week ago. The main problem is
frankmok
in
Leukaemia Support
3 years ago
CLL and Night Sweats
I have been on W&W for 1-1/2 years. Lymph % is 69.7, Lymph # 10.26 and WBC at 14.73. Just started having night sweats. What does one do? I am waiting on response from my doc but thought I would get feedback here. Thank you all for caring!
I have been on W&W for 1-1/2 years. Lymph % is 69.7, Lymph # 10.26 and WBC at 14.73. Just started having night sweats. What does one do? I am waiting on response from my doc but thought I would get feedback here. Thank you all for caring!
CBME
in
CLL Support
3 years ago
How do I safely live my life with CLL if my antibody test results are one of three scenarios?
I am a stage zero CLL patient of 5 years awaiting the results of my antibody test ordered by my oncologist due to the recent news that CLL patients are often not getting as many antibodies produced as hoped resulting from their CoVid vaccines. I had 2 doses Moderna (Feb and March). I have been very
I am a stage zero CLL patient of 5 years awaiting the results of my antibody test ordered by my oncologist due to the recent news that CLL patients are often not getting as many antibodies produced as hoped resulting from their CoVid vaccines. I had 2 doses Moderna (Feb and March). I have been very
learning2021
in
CLL Support
3 years ago
Newly approved drug effective against lung cancer caused by genetic mutation
The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients
The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial. The drug is designed to shut down the effects of the mutation, which is found in about 13% of patients
2greys
in
Lung Conditions Community Forum
3 years ago
Inflammatory Pathophysiology as a Contributor to MPN
« Clinical evidence that JAK2 inhibition by ruxolitinib in MF neither reliably reduces malignant clonal burden nor eliminates cytokine elevations, suggests targeting cytokine mediated signaling as a therapeutic strategy, which is being pursued in new clinical trials » « The clearly prominent role of
« Clinical evidence that JAK2 inhibition by ruxolitinib in MF neither reliably reduces malignant clonal burden nor eliminates cytokine elevations, suggests targeting cytokine mediated signaling as a therapeutic strategy, which is being pursued in new clinical trials » « The clearly prominent role of
Manouche
in
MPN Voice
3 years ago
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