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Rosuvastatin [Crestor] and Abiraterone [Zytiga]
Management and outcome: Rhabdomyolysis was resolutive after rosuvastatin and
abiraterone
discontinuation, and kidney function recovered. There was no recurrence of muscle toxicity after re-initiation of
abiraterone
alone.
Management and outcome: Rhabdomyolysis was resolutive after rosuvastatin and
abiraterone
discontinuation, and kidney function recovered. There was no recurrence of muscle toxicity after re-initiation of
abiraterone
alone.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Lynparza (olaparib )approved for mCRPC
Within each cohort, patients were randomized 2:1 to olaparib or physician's choice of
abiraterone
plus prednisone or enzalutamide. In cohort A, 162 patients received olaparib and 83 got
abiraterone
plus prednisone or enzalutamide.
Within each cohort, patients were randomized 2:1 to olaparib or physician's choice of
abiraterone
plus prednisone or enzalutamide. In cohort A, 162 patients received olaparib and 83 got
abiraterone
plus prednisone or enzalutamide.
Darryl
Partner
in
Advanced Prostate Cancer
4 years ago
Final 5-yr Survival analysis in the PREVAIL trial.
Enzalutamide reduced the hazard of death by 17% (hazard ratio 0.83; 95% confidence interval [CI] 0.75-0.93; p < 0.001), despite 65%, 54%, and 43% of placebo-treated patients receiving subsequent docetaxel,
abiraterone
, and enzalutamide, respectively.
Enzalutamide reduced the hazard of death by 17% (hazard ratio 0.83; 95% confidence interval [CI] 0.75-0.93; p < 0.001), despite 65%, 54%, and 43% of placebo-treated patients receiving subsequent docetaxel,
abiraterone
, and enzalutamide, respectively.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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Latest PSA whilst on Abiraterone
Previous months : 4.2, 6. 6, 12.9 Been on
Abiraterone
since January 2020. Also on Lupron, Metformin, and Lipitor. I'm a bit concerned that I'm already at a plateau with
Abiraterone
. I believe that I read on HU that chemos now may get the action of
Abiraterone
to be more effective.
Previous months : 4.2, 6. 6, 12.9 Been on
Abiraterone
since January 2020. Also on Lupron, Metformin, and Lipitor. I'm a bit concerned that I'm already at a plateau with
Abiraterone
. I believe that I read on HU that chemos now may get the action of
Abiraterone
to be more effective.
dockam
in
Advanced Prostate Cancer
4 years ago
PCa patients can benefit from 5-alpha-reductase Inhibitors.
Hence the continued interest in the AR axis, & the development of
Abiraterone
[Zytiga] & Enzalutamide [Xtandi]. The ultimate targets of AR axis-based therapy are DHT access to the AR, & AR translocation to the nucleus of the cell. It is therefore plausible that a 5ARI might have a useful role.
Hence the continued interest in the AR axis, & the development of
Abiraterone
[Zytiga] & Enzalutamide [Xtandi]. The ultimate targets of AR axis-based therapy are DHT access to the AR, & AR translocation to the nucleus of the cell. It is therefore plausible that a 5ARI might have a useful role.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
My story - so far
I was given the option to choose between chemotherapy and
Abiraterone
. I did my homework (which this forum was essential for it) and decided to go with
Abiraterone
. The side effects of chemotherapy had a big part in my decision to go with
Abiraterone
.
I was given the option to choose between chemotherapy and
Abiraterone
. I did my homework (which this forum was essential for it) and decided to go with
Abiraterone
. The side effects of chemotherapy had a big part in my decision to go with
Abiraterone
.
dorke
in
Advanced Prostate Cancer
4 years ago
Bipolar Androgen Therapy in Prostate Cancer.
More recent trials showed a further increase in overall survival when enzalutamide or
abiraterone
are associated with androgen deprivation therapy in hormone-sensitive disease.
More recent trials showed a further increase in overall survival when enzalutamide or
abiraterone
are associated with androgen deprivation therapy in hormone-sensitive disease.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Vertigo
My PSA has been creeping up and my MO says we may go to
Abiraterone
, which I believe doesn't have the seizure risk.
My PSA has been creeping up and my MO says we may go to
Abiraterone
, which I believe doesn't have the seizure risk.
xpbdb
in
Advanced Prostate Cancer
4 years ago
Apalutamide rash
I switched off
abiraterone
due to liver enzyme issues. Have been on apalutamide for about two months and suddenly developed a rash all over my body. I'm told I'll get over it eventually. Right now using a prescription cream. Anyone else get thru this and have input/advice?. Thanks
I switched off
abiraterone
due to liver enzyme issues. Have been on apalutamide for about two months and suddenly developed a rash all over my body. I'm told I'll get over it eventually. Right now using a prescription cream. Anyone else get thru this and have input/advice?. Thanks
PeakClimber
in
Advanced Prostate Cancer
4 years ago
Onc Live discussion of CRPC treatments and quality of life
Topics include: treatment sequencing, side effects, fears of chemotherapy, Docetaxel, Xofigo,
Abiraterone
, Enzalutamide, CARD trial, and Provenge. https://www.onclive.com/insights/chemotherapy-in-metastatic-prostate-cancer/maintaining-quality-of-life-in-metastatic-crpc
Topics include: treatment sequencing, side effects, fears of chemotherapy, Docetaxel, Xofigo,
Abiraterone
, Enzalutamide, CARD trial, and Provenge. https://www.onclive.com/insights/chemotherapy-in-metastatic-prostate-cancer/maintaining-quality-of-life-in-metastatic-crpc
Hidden
in
Advanced Prostate Cancer
4 years ago
Uncontrolled blood sugar
My dad has been taking
abiraterone
since july 2018 4 tablets in the morning before breakfast and prednisone 10 mg once daily after breakfast.Due to high blood sugar levels he was advised to take insulin 12 units in morning and 9 unites at night (since june 2019).Today,he checked his blood sugar randomly
My dad has been taking
abiraterone
since july 2018 4 tablets in the morning before breakfast and prednisone 10 mg once daily after breakfast.Due to high blood sugar levels he was advised to take insulin 12 units in morning and 9 unites at night (since june 2019).Today,he checked his blood sugar randomly
Vsahay
in
Advanced Prostate Cancer
4 years ago
RF cath ablation this AM @ 07:30. Wish me luck and prayers
Stopped
abiraterone
and prednisone today te-start Thursday. Wish me well and God speed recovery. Prayers . Thanks depotdoug. Doug
Stopped
abiraterone
and prednisone today te-start Thursday. Wish me well and God speed recovery. Prayers . Thanks depotdoug. Doug
depotdoug
in
Advanced Prostate Cancer
4 years ago
Olaparib for Metastatic Castration-Resistant Prostate Cancer
measures of response and patient-reported end points than either enzalutamide or
abiraterone
.
measures of response and patient-reported end points than either enzalutamide or
abiraterone
.
Balsam01
in
Advanced Prostate Cancer
4 years ago
New to this
On adt (prosap) +
abiraterone
. Wish you well and keep safe.
On adt (prosap) +
abiraterone
. Wish you well and keep safe.
Curehunter
in
Advanced Prostate Cancer
4 years ago
Another 6 months of happiness.
I was asked to join STAMPEDE trial, taking
Abiraterone
along side ADT. This was new at the time, and I was one of about eight hundred men starting this trial. 8+ years later doesn’t get any easier, expecting a rise in PSA. Anyway results are in and still immeasurable 🙂
I was asked to join STAMPEDE trial, taking
Abiraterone
along side ADT. This was new at the time, and I was one of about eight hundred men starting this trial. 8+ years later doesn’t get any easier, expecting a rise in PSA. Anyway results are in and still immeasurable 🙂
TommyTV
in
Positive Wellbeing During Self-Isolation
4 years ago
A day in the life
My latest blog post, in which a dead car battery briefly thwarts an attempt to pick up my
Abiraterone
from the pharmacy. It's actually been the first decent day for me since my most recent infusion last week. https://tominmotion.blogspot.com/2020/04/a-day-in-life.html
My latest blog post, in which a dead car battery briefly thwarts an attempt to pick up my
Abiraterone
from the pharmacy. It's actually been the first decent day for me since my most recent infusion last week. https://tominmotion.blogspot.com/2020/04/a-day-in-life.html
tom67inMA
in
Advanced Prostate Cancer
4 years ago
Fit or unfit for chemo (Docetaxel)?
She (MO) is not giving us a final decision yet (until he see my das and check again blood test), but taking those things in reference, she seems to be more inclined for
Abiraterone
or "waiting three months to stabilized" before chemo.
She (MO) is not giving us a final decision yet (until he see my das and check again blood test), but taking those things in reference, she seems to be more inclined for
Abiraterone
or "waiting three months to stabilized" before chemo.
olloreda
in
Advanced Prostate Cancer
4 years ago
Delay in getting next cycle of lu psma treatment😓
He seems to be quite well with good appetite and no pain at all (was in severe pain before infusion).Also continuing with
abiraterone
. How long can the next cycle be delayed?Is there anything else we need to take care of?Any suggestions would be of great help for us.
He seems to be quite well with good appetite and no pain at all (was in severe pain before infusion).Also continuing with
abiraterone
. How long can the next cycle be delayed?Is there anything else we need to take care of?Any suggestions would be of great help for us.
Vsahay
in
Advanced Prostate Cancer
4 years ago
TMPRSS2 & COVID-19
Bottom Line:
Men on
Abiraterone
[Zytiga] may be better protected than men on Lupron, say. & men on Avodart may be protected from the "alternative pathway".
Bottom Line:
Men on
Abiraterone
[Zytiga] may be better protected than men on Lupron, say. & men on Avodart may be protected from the "alternative pathway".
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Best Meds for MO CRPC?
Now on
abiraterone
& prednisone (plus Eligard); PSA rising; will probably try another drug. I'm thinking of the new receptor-inhibitors: apalutamide, darolutamide, enzalutamide. Tests show they extend metastasis-free survival by 36-40 months.
Now on
abiraterone
& prednisone (plus Eligard); PSA rising; will probably try another drug. I'm thinking of the new receptor-inhibitors: apalutamide, darolutamide, enzalutamide. Tests show they extend metastasis-free survival by 36-40 months.
yeatz
in
Advanced Prostate Cancer
4 years ago
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