Diagnosis of Scleroderma using the ACR criteria

[dacharya]

According to  the diagnostic criteria of the American College of Rheumatology, someone will be considered to have Scleroderma if the sum of the scores for each criteria is >9. So, only a blood test won't confirm that. However, the criteria for blood test is that the Scl-70 antigen test unit should be >1. But the blood test for Scl-70 will be different from lab to lab because many different testing kits are used all over the world. And the minimum limit for the antigen units would also vary on the lab report.

On my report the minimum limit for this antigen is <20.

So, my question is that how the diagnosis will be done based on a blood report to check for the unit >1 if the limit for the antigen varies from lab to lab?

My antigen value is 2.55 and does it mean that it's above 1 unit according to the ACR criteria?

rarediseaseadvisor.com/dise...

[OldTed60]

Given that this is just a support community, I’m not sure I agree that asking all these questions here is either useful or healthy unless the poster provides more information about themselves ie where they live and whether or not they are attending a rheumatologist. Otherwise there’s a tendency here to to dominate the feed with questions without providing any meaningful context. But just so that you at least have the relevant info to read and share with others such as this person, then here’s a link to the 2024 guidelines which are most pertinent to those who may have systemic sclerosis. There is also reference giving this relevance to overlap syndromes such as UCTD, MCTD etc: academic.oup.com/rheumatolo...

Meanwhile wishing you a very happy festive season! 🎄☺️

[dacharya in reply to OldTed60]

Thanks, I appreciate that!