I've had Reynauds since I was a teenager and about 2 years ago had difficulty breathing that took a year to diagnose as lack of blood flow to the heart. Medicine is fixing that currently but the lack of blood flow has now caused Avasular Necrosis in my left knee. My lateral femoral condyle collapsed on it self and caused a fracture on the surface of the bone. All of this by merely rolling over in bed. Has anyone had this type of progression over time?