Rough month-surprise recurrence

[Daisy2588]

In January 2023 I had a hysterectomy and was stage 1 A.

April 2024- 14 months later I had a major recurrence in the peritoneal area with numerous nodules, lymph nodes throughout and on omentum and with major ascites. I was hospitalized, had a paracentensis and began 6 chemo and Keytruda. I responded quickly and fully and all signs of disease resolved both on scan as well as Signatera which was zero. Maintance Keytruda alone began July 2024.

February 2025 a 2 cm suspicious cyst was noted on pelvic wall on a scan and rest of scan was clear. Onc says cyst is thick walled and he believes malignant and is restarting me on treatment due to the positive signatera coinciding with this cyst. No pet scan, no biopsy. Somewhat confused by this but am told mets can be diagnosed without biopsy. Not sure of amount of cancer because cyst is 2 cm but is also fluid filled. I am told targeted radiation is out since I am stage 4. I see other women having this and wonder. I am being guided toward a clinical trial for my genomic type. I am endometeroid, PMMR, ER positive, PR positive, Pik3 ca mutation, Kras 13c mutation. Path report says P53 wild type but the genetic test says p53 mutated. Low mutational burden..

Any thoughts? The trial is with an ER degrader shot and a Pik inhibitor Piqray

[Pickleballsadie]

Hi, I would go with clinical treatments when offered. I got better results with clinical trails then standard care.My drs office allows radiation for stage 4 but i dont qualify cuz my cancer is too spread out

[Magnificent1]

I was uterine 3a dx 1/1022 with recurrence 9/2023. For recurrence, had 5 chemo, then Keytruda/Lenvima. I've been stable since 1/2024 after starting the K/L. I still have peritoneal carcinomatosis, implant to liver and several to peritoneal, but not progressing at this time. I had a biopsy of abdominal mass to confirm recurrence of original cancer. No ascites or other issues. My particulars are pMMR, MSS, ER neg, HER-2 neg, Everyone is so unique in this journey. If my situation changes, I would pursue a clinical trial if options were exhausted. Best to you.