Ki 67 levels and cdks

[Kahe]

Hi all,

I had my primary, stage 2 diagnosis in 2010, reoccurence mbc March 2022, several tumours in my right lung.

Following failure on ribociclib, i was moved to Ibrance, faslo and letrozole in sept 22, stable since, ca153 marker in normal range.

My question here is for folks who may be able to comment on the correlation between ki67 levels and progression whilst on cdks. I recall recently reading of a 'friend' here who was having a long run on ibrance but with a ki67 level of just 1%. Mine is >30% so aggressive, (as I understand.) Wondering if anyone here can comment on correlation between ki levels and treatment failure?

Many thanks

[bikebabe]

I’m not sure. I had a grade 3 (aggressive) Pleomorphic lobular and think my ki67 with that one was 20% and I’ve been stable on palbo Letrozole for >3 yrs so far.Hopefully you’ll get other replies. Maybe it’s the oestrogen related aspects that are more significant.

[bikebabe in reply to bikebabe]

Best wishes to you

[Kahe in reply to bikebabe]

Hi Bike babe, thanks for your reply, much appreciated.

[mackster]

I'm on Palbociclib, Fulvestrant, plus Denosumab for 2 years. I'm in the UK and I never hear about markers, they're only interested in neutrophils. I know markers are often considered in the US, and it seems in Ireland. Sorry I can't comment, due to differences in treatment. May you long remain stable.

[Zumbagold in reply to mackster]

I am uk also. If you ask your consultant they can give you your marker numbers but agree they prefer to look at blood results and ct scan.

[mackster in reply to Zumbagold]

Thanks for that. I don't see a consultant tbh, possibly because I'm stable. I can raise issues of course, but it's very hands off where I am.

[Kahe in reply to Zumbagold]

Thank you Zumbagold for taking the time to reply. Yes I have my marker nos . Wishing you best of luck with your treatment 😍

[Kahe in reply to mackster]

Hi Mackster, thanks so much for your help and same to you, fingers crossed for years of stability 😍

[Goga156]

Since when has that Ki-67 level been measured? Since 2010?In the early stage, my mother's Ki-67 was 38. Eight years later, at recurrence, it was 22, and after six more years, in liver metastases, it was 18.

[Kahe in reply to Goga156]

Hi Goga, thanks for replying. My KI level is from 2022, I don't recall knowing the level when I was first diagnosed but interesting that levels can change over time. Wishing you all the best with your treatment 😍

[ba5083]

I'm not sure there is a correlation. From my understanding KI-67 determines how aggressive the cancer is but does not determine treatment. The OncotypeDX provides some course of treatment and indicates possible treatment effectiveness. I have yet to read anything that indicates treatment failures correlate to KI-67 numbers. My only suggestion would be to review any food, lifestyle or supplement interactions or any food, lifestyle or supplement that might enhance the effeteness. God Bless!

[Kahe in reply to ba5083]

Hi ba5083, thanks so much for taking the time to reply, best of luck with your treatment 😍

[monkeygirl62]

I believe the Ki-67 is used initially as prognostic indicator. I read this on Very well Health, "For breast cancer, Ki-67 is one of the main tumor biomarkers that your healthcare provider will check for when diagnosing, staging, and monitoring the cancer." I don't believe though the Ki- 67 alone determines treatment. It's just one in several diagnostic tests that oncologists use to make decisions but a low Ki-67 when there's been tumor progression anyway probably isn't a determining factor then for treatment. Mostly, it indicates the aggressiveness vs slow growth in cancer. All cancers can progress despite a low level of Ki-67. It's just my opinion on this, some else may have better information on it.

[Kahe in reply to monkeygirl62]

Hi monkey girl, of course you are right, cancers may progress regardless of ki levels. It seems there isn't an obvious correlation between Kis and progression on cdks. Thanks for your help 😍

[Logo999]

Hello, you take palbociclib with both faslodex and letrozole? Why are you given 2 anti hormonal?

[Kahe in reply to Logo999]

HI Logo,

this was the preference of my oncologist . Earlier studies apparently showed that the addition of fulvestrant to aroma inhib was associated with increased long-term survival as compared with ais alone, particularly notable in patients without previous exposure to adjuvant endocrine therapy (me). I do remember my onc saying that the practice of prescribing the 2 together was now less frequently done (I imagine other studies came along.....others here may know more) but it was still his preference and I went with the advice (how I would dearly love not to be receiving these monthly faslo injections 😀) Best K