TRIAL OF FULVESTRANT PLUS ABERMACICLIB WITH RUN IN OF FULVESTRANT

[25047]

I HAVE BEEEN ON LETROZOLE AND I-BRANCE 100 FOR APROX 3 1/2 YEARS AND my latest PET scan show more activity and the above study has been recommended to me by my Oncologist as the next course of action. Has anyone else been included in this study, funded by Eli Lily drug company, 28 patients, 15 from Houston Methodist, where i get my treatments. It is a 7 month study with monthly labs, checks, etc etc

Any suggestions, feedback, or experience with these drugs would be greatly appreciated,

(First diagnosed with stage 1 breast cancer in 2008

Lumpectomy and Radiation at Stanford

MBC DX 3 1/2 years ago

[HelenWi]

Abemaciclib plus fulvestrant are already standard of care. Sounds like this trial is comparing that to just taking Fulvestrant alone. To me it seems that your onco should already have an opinion whether it is worth trying Fulvrstrant by itself after you’ve been on Ibrance plus hormone blocker. My guess is that most onco would opt for a combination.

Here is a discussion by UCSF oncologists about taking fulvrstrant alone vs with cdk4/6 inhibitor. The discussion is mostly relative to first line treatment but they do touch on the concept of giving fulvestrant as second line and they say that you are better off adding the targeted therapy. The relevant discussion starts around 1:10.

youtu.be/mJoixQ5HOVQ?si=cYX...(Not working as expected?)

I hope this helps.

[Timtam56]

i’m on fulvestrant with this trial that I’m on which uses Piqray as well. I don’t know if it’s the piqray or the fulvestrant, but I’m doing okay. I hated the injections at first but I’m really used to them now and I have the two of them done together monthly. Depends on the nurses I get but mostly they’re okay and if I warm the injections up before they go into my body, they don’t hurt as much. as to how they’re working it’s so hard to answer that question because I haven’t got anything to go on. You’re either it or you’re not.

I am finding being on a trial very tiresome. I’ve just written a post about all of that. It’s doing my head in a bit. it’s a lot of time and energy that you have to give up for the hospital and I’m feeling a little bit like a lab rat.

[25047 in reply to Timtam56]

thank you for the reply, I understand how you feel, it’s giving up total control and trusting the knowledge, competency and advice of your ONCOLOGIST that this is the next right course of treatment. If it can postpone the “big Guns” for a while, I am all in, good luck, and may the Force be with us😘