Major Progression on Orserdu. Went from one spine met to multiple Mets and now liver. Has anyone had Tredlovy infusions?

[Elle713]

HR/PR+HER-

Chemo/Radiation/Mastectomy

Ibrance/Faslodex/Orserdu

[Adele_Julia]

Not yet. I would join the Trodelvy Facebook group !

[FiJaLo]

Sorry to hear about your experience on Orserdu. My mother had bad side effects from it, affecting her liver and red blood cell count, and had to come off. I’m not sure what she is on now, although it is chemo. Best of luck on this hard journey!

[Elle713 in reply to FiJaLo]

Thank you FiJaLo. Is she on IV chemo?

[FiJaLo]

Yes, but I’m not sure which one.

[Tanyateresa]

Hi, I've been on Trodelvy infusions for 2 months and not too bad side effects. Just tiredness and no hair. My bones are doing a lot better and not aching anymore. Will have my first scan today. Hope it works for you.

[LDR1]

I was on Trodelvy for 3 months and found it very tolerable with few side effects (besides hair loss). But it didn’t work for me so I’m moving on. Sounds like you have many other options including oral (pill-based) therapies such as Xeloda, Piqray, and Truqap (depending on gene mutations); then once you shift to IV chemo many people try Enhertu first before Trodelvy. Hope your oncologist will lay out the full range of options, with help from a genetic test to see what mutations you have.

[Elle713]

Thank You! I had to skip the oral options for now as she/I felt the progression was very quick and the spread was significant in just a short time. I was tested and had the ESR1 mutation which led me to Orserdu - which Clearly did not work. Mill hope for the best. Seems everyone has hair loss on Tredolvy - though onc and company say 45%.

I know it’s not the most important thing, but I’m having flashbacks to the first time and my original diagnosis 5 years ago.

Wising you the best!