metronomic capecitabine (XELODA)

[Shumawy]

Hello everyone, my mum ( mets to three mediastinal lymph nodes from 2018) had a Pet scan on Monday and we are awaiting the result (a lot of anxiety obviously, even if with the latest blood tests the TM Ca 15.3 was at 24 (range 0-32) and she started from a 43 at the beginning of all treatments in 2018, so I hope it's a good sign). In the last months, after discontinuing palbociclib due to toxicity, she has tried everolimus and exemestane but she had to stop after three months due to severe mucositis, despite having tried to decrease the dose. Since about three months ago she's doing metronomic capecitabine (1,500 mg/day nonstop), no side effects, hope it's working.

I wanted to ask if any of you do metronomic capecitabine with positive results

Thank you

[MyMiracle13]

I did metronomic dosing on Capecetabine also 1,500mg daily. It worked well for me for 2 years.

[Shumawy in reply to MyMiracle13]

Thanks for the answer, can I ask what therapy you did after? the onc wanted to add vinorelbine but then she said nothing. Maybe she will add it in case of progression?

[MyMiracle13 in reply to Shumawy]

yes my added vinorelbine on the 18th month but we had to do dose reduction because my bilirubin reached 2 which meant it was affecting my liver.

[Photo-Bug]

I, too, was on the same dose close to a year until the hand and foot syndrome became a problem . I have been off of it for over a year. I might be going back on it. After an upcoming bone marrow biopsy report and maybe 1 other test, I'll see what is next.

[Shumawy in reply to Photo-Bug]

Thanks for the reply 🙂 May I ask what you did in the year off from xeloda? And where are your mets? Thanks again

[Bettybuckets in reply to Shumawy]

what did you do in the the year you came off of it?

[Photo-Bug]

I did Piqray for for a little over 4 months-the diarrhea was not tolerable, next was 12 weeks of Taxol-no problems there except the markers did not come down, and now 4 months of exemestane-it is tolerable now but at the last reading the marker is up almost 20 points. During the next month I will have some tests to pin point a new therapy. In the meantime it is the waiting game.