New Drug to treat ‘hard to treat’ cancers like MBC

[Verbena1]

I haven’t researched this one yet but thought I’d share the article if anyone is interested

utsouthwestern.edu/newsroom...

[NPmary]

Thank you for sharing.

[OneLump22]

"Verrrry interrresting" as Arty Johnson used to say on the old Laugh -In variety show. Let us know what you find.

[Rego-park]

I like the article but when can we use this medicine?

[Verbena1 in reply to Rego-park]

I’m not sure but it looks like clinical trials will be starting in Q1 of 2023

prnewswire.com/news-release...

[DDIL1 in reply to Verbena1]

That would be great

[fancydog]

Bring it on, sooner rather than later Please!!!! THanks for posting

[Kruza]

Very interesting, it would open up a very promising treatment line for TNBC and ER cancers

[TammyCross in reply to Kruza]

Not ER+ -- nothing about that. It worked for triple negative, which is ER negative. The ER in the article referred to the molecule (ERx41) that is being used to treat triple negative. It is being tried against aggressive cancers, like triple negative.

[Kruza in reply to TammyCross]

Thanks for the clarification

[Cureforever in reply to TammyCross]

This is an excerpt from the article about erx41

Other experiments showed that in addition to ER-positive breast cancers and TNBC, ERX-41 is also effective against other cancer types with elevated endoplasmic reticulum stress, including pancreatic, glioblastoma and ovarian cancers, which all have few effective treatments. The endoplasmic reticulum is a structure in many cell types that performs assorted functions, including manufacture of proteins.

[TammyCross in reply to Cureforever]

Hmm, didn't see that; looks as though it is in the lit review. But I did see this in the discussion of results, which suggests that ERX41 is not effective against ER+ breast cancer:

"Since ERX-41 was derived from ERX-11 (which targets ER-α), we established that ERX-41 did not interact with ER-α. Using a time-resolved measurement with fluorescence resonance energy transfer (TR–FRET) assay, we demonstrated that ERX-41 does not interact with the ER-α ligand-binding domain (LBD), unlike fulvestrant and selective ER-α degraders such as GDC-0810, tamoxifen and ERX-11 (data shown for fulvestrant and GDC-0810) (Extended Data Fig. 4a,b). These data suggest that ERX-11 and ERX-41 have distinct molecular targets."

But there was something else on particular genetic profiles.

This study was on mice.

[Cureforever in reply to TammyCross]

Hi Tammy I consulted with thee expert. This drug doesn’t need er. It binds to lipa which is a protein produced in endoplasmic reticulum inside the cancer cells. This is why it has a broader use than ErSo

Let’s hope

Best

[TammyCross in reply to Cureforever]

Yes, I read about the Lipa. The biology of this is beyond me, and it seemed there was contradictory info about ER+ and whether it had to be an aggressive cancer. I hope it does work for the most common type of mbc. It seems further down the pike than ErSo, though.

[Cureforever in reply to TammyCross]

Hi Tammy. I consulted with the person who is a professional. She also has mbc. She interpreted the articles for me. It’s for all kinds of mbc. Let’s hope. Best,

Marina

[TammyCross in reply to Cureforever]

I was reading a different article from you, quoted below. Must be the midwestern researcher, but I couldn't find it again!

[Cureforever in reply to TammyCross]

Hi Tammy. I had another post with the links to two articles. Search for erx41 and you will see it. Best

[love2golfwell]

This sounds wonderful. Hope it can go to trials and get to people.

[RLN-overcomer]

Greetings: Thank you Sister/Warrior/Thriver/Advocate This drug study seems very promising. I hope/pray the human trials can start even sooner🙂 than early 2023. I thank GOD for the grant given by the N.I.H.😇

[TammyCross]

Disappointing talk with my onc about it today. She said there are other new drugs coming on and I might be interested in one of the clinical trials being conducted at Columbia Pres. I left the puff piece on ERX-41 with her, but she just kept saying there are other things coming down the pike for "your kind of cancer." Something that was tested on HER2+ now being tested on ER+. Maybe later, she said, I could get into one of those.

[Verbena1 in reply to TammyCross]

Hi, TammyCross have you been offered or gone on Enhertu? I’m also HER2+ and it treats that, shrunk my masses in days after my first IV.

Also saw that you stopped xcheva due to dental issues…how is that going? I’ve been on xcheva 2 years but would really like to at least halt it for a while, I have a decent amount of dental work to be done but didn’t know true risks of coming off of it for months while also getting Eligard hormone shots. (Researching the connection from dental issues and MBC).

Thanks

[TammyCross]

I am not HER2+, just ER+, no mutations, nothing special.

I stopped Xgeva too late. I lost a tooth and part of my jaw on upper left, and three teeth and a big chunk of jaw on upper right. It is not good. Just hoping that bones will heal and I can keep remaining teeth now that I have been off Xgeva for 9 months.

Really the only reason to be on Xgeva is if you have bone mets. I did, but they were gone and onc. continued me on it and I started refusing. It was dental implants that caused the problem.

[Verbena1 in reply to TammyCross]

so sorry to hear that. That’s why I have been on xcheva, due to bone mets, and it’s been almost 2 years. It seems long to me but I don’t know normal amounts of time for this drug… I’m trying to find an alternative to taking it, especially now that my scans are improving. I hope that you keep everything too. Thanks for your response!

[TammyCross in reply to Verbena1]

The risk of ONJ is low, but goes up every year you are on it. My bone mets resolved after 2 years so I didn't need it anymore, but onc. kept me on it. It sounds like yours are headed in the right direction. The alternative for bones is bisphosphonates, but they also carry risk of ONJ. Xgeva seems to do more healing than the bisphosphonates; it does something different. It is fairly new, so I think they don't know all the problems, but it is known that you shouldn't have dental work while on it. One of the things they do not know is how long you have to be off it before it is no longer risky to have dental work. Everyone guesses, but they sound as though they know. They don't. I was off four months, almost 5, when I got ONJ.